nicardipine-1600 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the nicardipine-1600 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AHR aryl hydrocarbon receptor
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANK2 ankyrin 2, neuronal
APOC1 apolipoprotein C-I
APP amyloid beta (A4) precursor protein
ARHGAP32 Rho GTPase activating protein 32
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZI2 5-azacytidine induced 2
BCAP29 B-cell receptor-associated protein 29
BCLAF1 BCL2-associated transcription factor 1
BRCA2 breast cancer 2, early onset
C2ORF68 chromosome 2 open reading frame 68
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CCL20 chemokine (C-C motif) ligand 20
CD164 CD164 molecule, sialomucin
CD86 CD86 molecule
CEP85 centrosomal protein 85kDa
CHD9 chromodomain helicase DNA binding protein 9
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCC1 chloride channel CLIC-like 1
CPOX coproporphyrinogen oxidase
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CYB561 cytochrome b561
DENND4A DENN/MADD domain containing 4A
DERL1 derlin 1
EGR3 early growth response 3
ELF4 E74-like factor 4 (ets domain transcription factor)
ELK1 ELK1, member of ETS oncogene family
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM188A family with sequence similarity 188, member A
FAM3C family with sequence similarity 3, member C
FLRT2 fibronectin leucine rich transmembrane protein 2
FRMD4B FERM domain containing 4B
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GSE1 Gse1 coiled-coil protein
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HPS1 Hermansky-Pudlak syndrome 1
HUS1 HUS1 checkpoint homolog (S. pombe)
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IL18 interleukin 18
IL1B interleukin 1, beta
JAG1 jagged 1
KATNBL1 katanin p80 subunit B-like 1
KCTD3 potassium channel tetramerization domain containing 3
KIAA1109 KIAA1109
KRIT1 KRIT1, ankyrin repeat containing
LIN7C lin-7 homolog C (C. elegans)
MAPKBP1 mitogen-activated protein kinase binding protein 1
MOSPD2 motile sperm domain containing 2
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MTM1 myotubularin 1
NBPF10 neuroblastoma breakpoint family, member 10
NBR1 neighbor of BRCA1 gene 1
NDE1 nudE neurodevelopment protein 1
NDRG2 NDRG family member 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NNT nicotinamide nucleotide transhydrogenase
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1R16B protein phosphatase 1, regulatory subunit 16B
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RAD17 RAD17 homolog (S. pombe)
RALB v-ral simian leukemia viral oncogene homolog B
RIOK3 RIO kinase 3
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPL7 ribosomal protein L7
RPS2 ribosomal protein S2
RSAD1 radical S-adenosyl methionine domain containing 1
RWDD3 RWD domain containing 3
SCAF4 SR-related CTD-associated factor 4
SDC2 syndecan 2
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEC23B Sec23 homolog B (S. cerevisiae)
SECISBP2 SECIS binding protein 2
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC25A40 solute carrier family 25, member 40
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMC2 structural maintenance of chromosomes 2
SOD2 superoxide dismutase 2, mitochondrial
TRAPPC11 trafficking protein particle complex 11
TTC37 tetratricopeptide repeat domain 37
TTF2 transcription termination factor, RNA polymerase II
UFL1 UFM1-specific ligase 1
VASP vasodilator-stimulated phosphoprotein
WDR61 WD repeat domain 61
WSB1 WD repeat and SOCS box containing 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZC3H12A zinc finger CCCH-type containing 12A
ZNF280D zinc finger protein 280D

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ADORA3 adenosine A3 receptor
ANAPC2 anaphase promoting complex subunit 2
ANKRD28 ankyrin repeat domain 28
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARID5A AT rich interactive domain 5A (MRF1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASB13 ankyrin repeat and SOCS box containing 13
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BATF basic leucine zipper transcription factor, ATF-like
CAPN1 calpain 1, (mu/I) large subunit
CBR1 carbonyl reductase 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CDK5 cyclin-dependent kinase 5
CENPM centromere protein M
CER1 cerberus 1, DAN family BMP antagonist
CFAP74 cilia and flagella associated protein 74
CGRRF1 cell growth regulator with ring finger domain 1
CHMP1A charged multivesicular body protein 1A
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CIC capicua transcriptional repressor
CIDEC cell death-inducing DFFA-like effector c
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNTD2 cyclin N-terminal domain containing 2
COQ6 coenzyme Q6 monooxygenase
CPNE1 copine I
CRELD2 cysteine-rich with EGF-like domains 2
CRIPT cysteine-rich PDZ-binding protein
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDIT3 DNA-damage-inducible transcript 3
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
EDAR ectodysplasin A receptor
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EGR2 early growth response 2
EPX eosinophil peroxidase
ERCC8 excision repair cross-complementation group 8
FANCE Fanconi anemia, complementation group E
GRPR gastrin-releasing peptide receptor
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HP haptoglobin
IP6K2 inositol hexakisphosphate kinase 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LSP1 lymphocyte-specific protein 1
MAPK3 mitogen-activated protein kinase 3
MED24 mediator complex subunit 24
MOSPD3 motile sperm domain containing 3
MPV17 MpV17 mitochondrial inner membrane protein
MRPL2 mitochondrial ribosomal protein L2
MRPS27 mitochondrial ribosomal protein S27
MSL2 male-specific lethal 2 homolog (Drosophila)
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MYLIP myosin regulatory light chain interacting protein
NCF1C neutrophil cytosolic factor 1C pseudogene
OCEL1 occludin/ELL domain containing 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
ORAI3 ORAI calcium release-activated calcium modulator 3
PADI1 peptidyl arginine deiminase, type I
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIGR polymeric immunoglobulin receptor
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PMM2 phosphomannomutase 2
PSKH1 protein serine kinase H1
QRICH1 glutamine-rich 1
RAB1B RAB1B, member RAS oncogene family
RPL13P5 ribosomal protein L13 pseudogene 5
RTN3 reticulon 3
RWDD2B RWD domain containing 2B
SCAP SREBF chaperone
SDAD1 SDA1 domain containing 1
SDC4 syndecan 4
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERTAD3 SERTA domain containing 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC25A38 solute carrier family 25, member 38
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLN sarcolipin
SPX spexin hormone
STAR steroidogenic acute regulatory protein
STARD3 StAR-related lipid transfer (START) domain containing 3
TAC3 tachykinin 3
TBL3 transducin (beta)-like 3
TCTN2 tectonic family member 2
THBS4 thrombospondin 4
TMEM184B transmembrane protein 184B
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBIAD1 UbiA prenyltransferase domain containing 1
WDR44 WD repeat domain 44
WDR46 WD repeat domain 46
ZC3H3 zinc finger CCCH-type containing 3
ZNF189 zinc finger protein 189
ZNF197 zinc finger protein 197