nicergoline-1374 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the nicergoline-1374 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AIP aryl hydrocarbon receptor interacting protein
ALAD aminolevulinate dehydratase
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ATG13 autophagy related 13
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BAMBI BMP and activin membrane-bound inhibitor
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BHLHE40 basic helix-loop-helix family, member e40
BRAF B-Raf proto-oncogene, serine/threonine kinase
C2ORF68 chromosome 2 open reading frame 68
C5ORF45 chromosome 5 open reading frame 45
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD300A CD300a molecule
CD70 CD70 molecule
CDC42 cell division cycle 42
CDK2 cyclin-dependent kinase 2
CLCN6 chloride channel, voltage-sensitive 6
COIL coilin
CREB3 cAMP responsive element binding protein 3
CRY2 cryptochrome circadian clock 2
DAXX death-domain associated protein
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DLK2 delta-like 2 homolog (Drosophila)
DUS2 dihydrouridine synthase 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FADS1 fatty acid desaturase 1
FAM105A family with sequence similarity 105, member A
FAM153A family with sequence similarity 153, member A
FEM1B fem-1 homolog b (C. elegans)
FZD2 frizzled class receptor 2
GOLGA2 golgin A2
H2AFY H2A histone family, member Y
HIST1H4J histone cluster 1, H4j
IL6R interleukin 6 receptor
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRC14 leucine rich repeat containing 14
LZTS1 leucine zipper, putative tumor suppressor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBD1 methyl-CpG binding domain protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MECP2 methyl CpG binding protein 2
MED6 mediator complex subunit 6
MUC2 mucin 2, oligomeric mucus/gel-forming
MZF1 myeloid zinc finger 1
NAGLU N-acetylglucosaminidase, alpha
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFX1 nuclear transcription factor, X-box binding 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCIF1 PDX1 C-terminal inhibiting factor 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE3B phosphodiesterase 3B, cGMP-inhibited
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLEC plectin
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP1R7 protein phosphatase 1, regulatory subunit 7
PRRC2C proline-rich coiled-coil 2C
PTCRA pre T-cell antigen receptor alpha
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
QTRT1 queuine tRNA-ribosyltransferase 1
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN3 Ras and Rab interactor 3
SAG S-antigen; retina and pineal gland (arrestin)
SCYL3 SCY1-like 3 (S. cerevisiae)
SEC31B SEC31 homolog B (S. cerevisiae)
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SFTPB surfactant protein B
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
STK19 serine/threonine kinase 19
TFEB transcription factor EB
TM7SF2 transmembrane 7 superfamily member 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM3 tripartite motif containing 3
TRRAP transformation/transcription domain-associated protein
TSSC4 tumor suppressing subtransferable candidate 4
VPRBP Vpr (HIV-1) binding protein
WNT6 wingless-type MMTV integration site family, member 6
WRAP73 WD repeat containing, antisense to TP73
YIPF6 Yip1 domain family, member 6
YLPM1 YLP motif containing 1
ZER1 zyg-11 related, cell cycle regulator
ZFHX2 zinc finger homeobox 2
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ADRB2 adrenoceptor beta 2, surface
ALPK1 alpha-kinase 1
AP1AR adaptor-related protein complex 1 associated regulatory protein
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX5 armadillo repeat containing, X-linked 5
ASAP1-IT1 ASAP1 intronic transcript 1
ATAD2B ATPase family, AAA domain containing 2B
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAHD1 bromo adjacent homology domain containing 1
BTNL3 butyrophilin-like 3
C12ORF43 chromosome 12 open reading frame 43
C1ORF216 chromosome 1 open reading frame 216
C1ORF54 chromosome 1 open reading frame 54
CA7 carbonic anhydrase VII
CCDC130 coiled-coil domain containing 130
CCDC15 coiled-coil domain containing 15
CEND1 cell cycle exit and neuronal differentiation 1
CEP170B centrosomal protein 170B
CHUK conserved helix-loop-helix ubiquitous kinase
CRYBB2P1 crystallin, beta B2 pseudogene 1
CRYL1 crystallin, lambda 1
CYCS cytochrome c, somatic
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DEAF1 DEAF1 transcription factor
DMXL1 Dmx-like 1
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYSF dysferlin
EDAR ectodysplasin A receptor
FGF4 fibroblast growth factor 4
FMO4 flavin containing monooxygenase 4
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GLB1L2 galactosidase, beta 1-like 2
GMCL1 germ cell-less, spermatogenesis associated 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GRWD1 glutamate-rich WD repeat containing 1
GSE1 Gse1 coiled-coil protein
GSTA4 glutathione S-transferase alpha 4
GSTM2 glutathione S-transferase mu 2 (muscle)
GUSBP3 glucuronidase, beta pseudogene 3
HDAC9 histone deacetylase 9
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIRA histone cell cycle regulator
INPPL1 inositol polyphosphate phosphatase-like 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCTD20 potassium channel tetramerization domain containing 20
KCTD3 potassium channel tetramerization domain containing 3
LMBR1L limb development membrane protein 1-like
MAPK10 mitogen-activated protein kinase 10
METRN meteorin, glial cell differentiation regulator
NDE1 nudE neurodevelopment protein 1
NECAP1 NECAP endocytosis associated 1
NFE2 nuclear factor, erythroid 2
NRGN neurogranin (protein kinase C substrate, RC3)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAK1IP1 PAK1 interacting protein 1
PCDHGB5 protocadherin gamma subfamily B, 5
PEX7 peroxisomal biogenesis factor 7
PNOC prepronociceptin
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP6R3 protein phosphatase 6, regulatory subunit 3
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PTER phosphotriesterase related
RABL6 RAB, member RAS oncogene family-like 6
RBBP5 retinoblastoma binding protein 5
RBMS3 RNA binding motif, single stranded interacting protein 3
RFX7 regulatory factor X, 7
RIN1 Ras and Rab interactor 1
RPAP1 RNA polymerase II associated protein 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RWDD3 RWD domain containing 3
SCAMP5 secretory carrier membrane protein 5
SIRT6 sirtuin 6
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLN sarcolipin
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SRBD1 S1 RNA binding domain 1
TAC3 tachykinin 3
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TMBIM4 transmembrane BAX inhibitor motif containing 4
TMEM165 transmembrane protein 165
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TOR4A torsin family 4, member A
TRAPPC11 trafficking protein particle complex 11
TSC22D1 TSC22 domain family, member 1
TTC13 tetratricopeptide repeat domain 13
UBFD1 ubiquitin family domain containing 1
WDR82 WD repeat domain 82
YY2 YY2 transcription factor
ZMYM3 zinc finger, MYM-type 3
ZNF273 zinc finger protein 273
ZNF33B zinc finger protein 33B
ZNRD1-AS1 ZNRD1 antisense RNA 1
ZW10 zw10 kinetochore protein