nicergoline-2220 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the nicergoline-2220 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRE1 adhesion G protein-coupled receptor E1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALCAM activated leukocyte cell adhesion molecule
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ASIC1 acid sensing (proton gated) ion channel 1
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAZ1B bromodomain adjacent to zinc finger domain, 1B
C3 complement component 3
CAPN9 calpain 9
CD40 CD40 molecule, TNF receptor superfamily member 5
CD48 CD48 molecule
CD70 CD70 molecule
CFHR4 complement factor H-related 4
CFP complement factor properdin
CLDN17 claudin 17
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
COL13A1 collagen, type XIII, alpha 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CSNK1G1 casein kinase 1, gamma 1
CTNS cystinosin, lysosomal cystine transporter
DGCR8 DGCR8 microprocessor complex subunit
DLX2 distal-less homeobox 2
DNASE1L2 deoxyribonuclease I-like 2
EML2 echinoderm microtubule associated protein like 2
FABP6 fatty acid binding protein 6, ileal
FASLG Fas ligand (TNF superfamily, member 6)
GLIPR1 GLI pathogenesis-related 1
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HES2 hes family bHLH transcription factor 2
HIST1H1E histone cluster 1, H1e
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA7 homeobox A7
HOXB2 homeobox B2
HYAL1 hyaluronoglucosaminidase 1
ICA1 islet cell autoantigen 1, 69kDa
IL1RN interleukin 1 receptor antagonist
INO80B INO80 complex subunit B
INSIG1 insulin induced gene 1
KAT6A K(lysine) acetyltransferase 6A
KIF25-AS1 KIF25 antisense RNA 1
KLHL20 kelch-like family member 20
KRT36 keratin 36, type I
KXD1 KxDL motif containing 1
MAPK7 mitogen-activated protein kinase 7
MBD2 methyl-CpG binding domain protein 2
MED25 mediator complex subunit 25
MTMR8 myotubularin related protein 8
MVD mevalonate (diphospho) decarboxylase
NME5 NME/NM23 family member 5
NME8 NME/NM23 family member 8
NSUN6 NOP2/Sun domain family, member 6
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP88 nucleoporin 88kDa
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PDE4DIP phosphodiesterase 4D interacting protein
PEAK1 pseudopodium-enriched atypical kinase 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCH1 phospholipase C, eta 1
PTAFR platelet-activating factor receptor
PTPRJ protein tyrosine phosphatase, receptor type, J
RB1 retinoblastoma 1
RIN1 Ras and Rab interactor 1
RLN1 relaxin 1
RPGR retinitis pigmentosa GTPase regulator
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A8 S100 calcium binding protein A8
SAG S-antigen; retina and pineal gland (arrestin)
SAMD9 sterile alpha motif domain containing 9
SEC24A SEC24 family member A
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SH3BP2 SH3-domain binding protein 2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SNX13 sorting nexin 13
SOCS1 suppressor of cytokine signaling 1
SORBS1 sorbin and SH3 domain containing 1
SOX30 SRY (sex determining region Y)-box 30
SPTBN5 spectrin, beta, non-erythrocytic 5
SRPK2 SRSF protein kinase 2
SRSF5 serine/arginine-rich splicing factor 5
SUGP1 SURP and G patch domain containing 1
SYNJ1 synaptojanin 1
TBC1D2 TBC1 domain family, member 2
TBR1 T-box, brain, 1
TFF2 trefoil factor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TRIM29 tripartite motif containing 29
TSGA10 testis specific, 10
VCX2 variable charge, X-linked 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF358 zinc finger protein 358
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ALPK1 alpha-kinase 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
AXIN1 axin 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAHCC1 BAH domain and coiled-coil containing 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BTBD2 BTB (POZ) domain containing 2
C14ORF79 chromosome 14 open reading frame 79
C4ORF29 chromosome 4 open reading frame 29
CD34 CD34 molecule
CD82 CD82 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDON cell adhesion associated, oncogene regulated
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CORO7 coronin 7
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DENND4C DENN/MADD domain containing 4C
DIXDC1 DIX domain containing 1
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DSCAM Down syndrome cell adhesion molecule
DTX2 deltex 2, E3 ubiquitin ligase
EFHD2 EF-hand domain family, member D2
EPPK1 epiplakin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ETNK2 ethanolamine kinase 2
EXO5 exonuclease 5
FBXL2 F-box and leucine-rich repeat protein 2
FOSL1 FOS-like antigen 1
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRTP1 growth hormone regulated TBC protein 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HDAC11 histone deacetylase 11
HIRA histone cell cycle regulator
HIST1H2BC histone cluster 1, H2bc
HPX hemopexin
IFT54 intraflagellar transport 54
IPP intracisternal A particle-promoted polypeptide
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRS1 insulin receptor substrate 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KDM8 lysine (K)-specific demethylase 8
KIF13A kinesin family member 13A
KRI1 KRI1 homolog (S. cerevisiae)
KRT15 keratin 15, type I
LAMB3 laminin, beta 3
LIME1 Lck interacting transmembrane adaptor 1
MCOLN1 mucolipin 1
MGC12488
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MPHOSPH8 M-phase phosphoprotein 8
NDE1 nudE neurodevelopment protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPTX1 neuronal pentraxin I
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PALM paralemmin
PCDHB3 protocadherin beta 3
PEX26 peroxisomal biogenesis factor 26
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLIN3 perilipin 3
PPT2 palmitoyl-protein thioesterase 2
PRPH peripherin
PTDSS2 phosphatidylserine synthase 2
PTPRU protein tyrosine phosphatase, receptor type, U
RAB3A RAB3A, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SIPA1 signal-induced proliferation-associated 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SND1-IT1 SND1 intronic transcript 1
ST5 suppression of tumorigenicity 5
STIM1 stromal interaction molecule 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D17 TBC1 domain family, member 17
TEAD3 TEA domain family member 3
TEX30 testis expressed 30
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMPRSS4 transmembrane protease, serine 4
TNS2 tensin 2
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TYRP1 tyrosinase-related protein 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WNT10B wingless-type MMTV integration site family, member 10B
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZFHX3 zinc finger homeobox 3
ZNF282 zinc finger protein 282
ZNF286A zinc finger protein 286A
ZNF37BP zinc finger protein 37B, pseudogene
ZNF611 zinc finger protein 611
ZNF770 zinc finger protein 770