niclosamide-1916 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the niclosamide-1916 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANKRD12 ankyrin repeat domain 12
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BIRC3 baculoviral IAP repeat containing 3
BRD2 bromodomain containing 2
C2CD2L C2CD2-like
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN14 claudin 14
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELL2 elongation factor, RNA polymerase II, 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM129A family with sequence similarity 129, member A
FGD6 FYVE, RhoGEF and PH domain containing 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HBP1 HMG-box transcription factor 1
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KLHL24 kelch-like family member 24
KRT17 keratin 17, type I
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LRRC49 leucine rich repeat containing 49
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
MSL2 male-specific lethal 2 homolog (Drosophila)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
PELI1 pellino E3 ubiquitin protein ligase 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RGS4 regulator of G-protein signaling 4
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
RUSC2 RUN and SH3 domain containing 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC2 stanniocalcin 2
STK10 serine/threonine kinase 10
STX3 syntaxin 3
TGIF1 TGFB-induced factor homeobox 1
TMEM50B transmembrane protein 50B
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
USF2 upstream transcription factor 2, c-fos interacting
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ANKRD46 ankyrin repeat domain 46
ASTE1 asteroid homolog 1 (Drosophila)
B3GNT1
BHLHE41 basic helix-loop-helix family, member e41
C5ORF30 chromosome 5 open reading frame 30
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CD3EAP CD3e molecule, epsilon associated protein
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
COPZ1 coatomer protein complex, subunit zeta 1
CROT carnitine O-octanoyltransferase
CTNNBIP1 catenin, beta interacting protein 1
CUTC cutC copper transporter
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DROSHA drosha, ribonuclease type III
DUSP4 dual specificity phosphatase 4
E2F8 E2F transcription factor 8
ECHDC2 enoyl CoA hydratase domain containing 2
EPM2AIP1 EPM2A (laforin) interacting protein 1
FADD Fas (TNFRSF6)-associated via death domain
FAM222B family with sequence similarity 222, member B
FASTKD1 FAST kinase domains 1
FBXO5 F-box protein 5
FPGT fucose-1-phosphate guanylyltransferase
FXN frataxin
GEMIN6 gem (nuclear organelle) associated protein 6
HAS2 hyaluronan synthase 2
HILPDA hypoxia inducible lipid droplet-associated
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
KDM3A lysine (K)-specific demethylase 3A
KIFC1 kinesin family member C1
LBR lamin B receptor
LINC00339 long intergenic non-protein coding RNA 339
LMNB1 lamin B1
LZTR1 leucine-zipper-like transcription regulator 1
MED7 mediator complex subunit 7
MEIS3P1 Meis homeobox 3 pseudogene 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MNX1 motor neuron and pancreas homeobox 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NAP1L2 nucleosome assembly protein 1-like 2
OCEL1 occludin/ELL domain containing 1
PCTP phosphatidylcholine transfer protein
PCYOX1L prenylcysteine oxidase 1 like
PFAS phosphoribosylformylglycinamidine synthase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPAP2B phosphatidic acid phosphatase type 2B
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PSRC1 proline/serine-rich coiled-coil 1
RBM14 RNA binding motif protein 14
RIN2 Ras and Rab interactor 2
RIPK4 receptor-interacting serine-threonine kinase 4
RPL23AP32 ribosomal protein L23a pseudogene 32
RPP40 ribonuclease P/MRP 40kDa subunit
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCAMP5 secretory carrier membrane protein 5
SFT2D2 SFT2 domain containing 2
SLC12A9 solute carrier family 12, member 9
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35E3 solute carrier family 35, member E3
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
STAU2 staufen double-stranded RNA binding protein 2
SUOX sulfite oxidase
TMEM104 transmembrane protein 104
TMEM164 transmembrane protein 164
TMEM168 transmembrane protein 168
TMEM177 transmembrane protein 177
TMEM184C transmembrane protein 184C
TRIM32 tripartite motif containing 32
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPYL4 TSPY-like 4
TTI1 TELO2 interacting protein 1
UBXN8 UBX domain protein 8
WDR5B WD repeat domain 5B
XPA xeroderma pigmentosum, complementation group A
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF175 zinc finger protein 175
ZNF248 zinc finger protein 248
ZNF85 zinc finger protein 85