nicotine Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2. It has been isolated from Nicotiana tabacum. (Chemical Entities of Biological Interest Ontology, CHEBI_18723)
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Genes

108 genes co-occuring with the biological term nicotine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADORA2A adenosine A2a receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANAPC1 anaphase promoting complex subunit 1
ANKK1 ankyrin repeat and kinase domain containing 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
BDNF brain-derived neurotrophic factor
CARTPT CART prepropeptide
CHAT choline O-acetyltransferase
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CNR1 cannabinoid receptor 1 (brain)
COL2A1 collagen, type II, alpha 1
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAOA D-amino acid oxidase activator
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFB4A defensin, beta 4A
DLG4 discs, large homolog 4 (Drosophila)
DNM1 dynamin 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
ESR1 estrogen receptor 1
FHIT fragile histidine triad
FMO1 flavin containing monooxygenase 1
FMO3 flavin containing monooxygenase 3
FRMD4A FERM domain containing 4A
GABARAP GABA(A) receptor-associated protein
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GALR1 galanin receptor 1
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GHRL ghrelin/obestatin prepropeptide
GLB1 galactosidase, beta 1
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GSK3B glycogen synthase kinase 3 beta
HCRT hypocretin (orexin) neuropeptide precursor
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMOX1 heme oxygenase 1
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
ICAM1 intercellular adhesion molecule 1
JAK2 Janus kinase 2
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
MAOA monoamine oxidase A
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK3 mitogen-activated protein kinase 3
MIR21 microRNA 21
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRXN1 neurexin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPRM1 opioid receptor, mu 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAT plasminogen activator, tissue
POR P450 (cytochrome) oxidoreductase
POSTN periostin, osteoblast specific factor
PPARD peroxisome proliferator-activated receptor delta
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PTEN phosphatase and tensin homolog
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RHOA ras homolog family member A
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAS2R38 taste receptor, type 2, member 38
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1 transforming growth factor, beta 1
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VCAM1 vascular cell adhesion molecule 1
WNT3A wingless-type MMTV integration site family, member 3A
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma