nicotinic acid-3381 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the nicotinic acid-3381 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACAN aggrecan
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ANGPTL2 angiopoietin-like 2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARC activity-regulated cytoskeleton-associated protein
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATG10 autophagy related 10
BTF3P11 basic transcription factor 3 pseudogene 11
C18ORF25 chromosome 18 open reading frame 25
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCRL2 chemokine (C-C motif) receptor-like 2
CD47 CD47 molecule
CD6 CD6 molecule
CDC42 cell division cycle 42
CDO1 cysteine dioxygenase type 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEP41 centrosomal protein 41kDa
CERS4 ceramide synthase 4
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CTNS cystinosin, lysosomal cystine transporter
CYLD cylindromatosis (turban tumor syndrome)
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DGCR8 DGCR8 microprocessor complex subunit
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
ELP6 elongator acetyltransferase complex subunit 6
EMID1 EMI domain containing 1
ERCC2 excision repair cross-complementation group 2
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FCAR Fc fragment of IgA receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGF5 fibroblast growth factor 5
FOXG1 forkhead box G1
FRMD1 FERM domain containing 1
FRMD8 FERM domain containing 8
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GK2 glycerol kinase 2
GM2A GM2 ganglioside activator
GPR176 G protein-coupled receptor 176
GVINP1 GTPase, very large interferon inducible pseudogene 1
HCG4 HLA complex group 4 (non-protein coding)
HIST1H2BM histone cluster 1, H2bm
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLF hepatic leukemia factor
HR hair growth associated
IGF2-AS IGF2 antisense RNA
IGLJ3 immunoglobulin lambda joining 3
IL18 interleukin 18
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KXD1 KxDL motif containing 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMNA lamin A/C
MAP1A microtubule-associated protein 1A
MAPK7 mitogen-activated protein kinase 7
MET MET proto-oncogene, receptor tyrosine kinase
MFAP3L microfibrillar-associated protein 3-like
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MRPL41 mitochondrial ribosomal protein L41
MST1 macrophage stimulating 1
MYOZ1 myozenin 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOV nephroblastoma overexpressed
PEX3 peroxisomal biogenesis factor 3
PHC3 polyhomeotic homolog 3 (Drosophila)
PHF7 PHD finger protein 7
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PNMAL1 paraneoplastic Ma antigen family-like 1
POPDC2 popeye domain containing 2
PSG4 pregnancy specific beta-1-glycoprotein 4
PTAFR platelet-activating factor receptor
RAB33A RAB33A, member RAS oncogene family
RNF122 ring finger protein 122
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SELL selectin L
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTBN5 spectrin, beta, non-erythrocytic 5
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SVIL supervillin
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBXA2R thromboxane A2 receptor
TRBC1 T cell receptor beta constant 1
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TULP1 tubby like protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP46 ubiquitin specific peptidase 46
WNT16 wingless-type MMTV integration site family, member 16
WSCD1 WSC domain containing 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XAF1 XIAP associated factor 1
YY2 YY2 transcription factor

decreased expression

Symbol Name
ADTRP androgen-dependent TFPI-regulating protein
AHNAK2 AHNAK nucleoprotein 2
ALPK1 alpha-kinase 1
BAHCC1 BAH domain and coiled-coil containing 1
BCORL1 BCL6 corepressor-like 1
C11ORF30 chromosome 11 open reading frame 30
C3 complement component 3
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC9 coiled-coil domain containing 9
CDK18 cyclin-dependent kinase 18
CDK3 cyclin-dependent kinase 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CENPO centromere protein O
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHST10 carbohydrate sulfotransferase 10
CNR2 cannabinoid receptor 2 (macrophage)
CRIP1 cysteine-rich protein 1 (intestinal)
DBF4B DBF4 zinc finger B
DEAF1 DEAF1 transcription factor
DNM3 dynamin 3
DTX2 deltex 2, E3 ubiquitin ligase
EDAR ectodysplasin A receptor
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELMO3 engulfment and cell motility 3
ETV6 ets variant 6
F3 coagulation factor III (thromboplastin, tissue factor)
FAM131A family with sequence similarity 131, member A
FAM53B family with sequence similarity 53, member B
FBXO22 F-box protein 22
FCHSD2 FCH and double SH3 domains 2
FOXI1 forkhead box I1
GADD45G growth arrest and DNA-damage-inducible, gamma
GBP2 guanylate binding protein 2, interferon-inducible
GPR143 G protein-coupled receptor 143
GPR21 G protein-coupled receptor 21
GRAMD1C GRAM domain containing 1C
GRTP1 growth hormone regulated TBC protein 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2AL histone cluster 1, H2al
HIST1H4A histone cluster 1, H4a
HYAL1 hyaluronoglucosaminidase 1
INHA inhibin, alpha
IRX4 iroquois homeobox 4
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUNB jun B proto-oncogene
KIAA0355 KIAA0355
KRT83 keratin 83, type II
LHX1 LIM homeobox 1
LOXL3 lysyl oxidase-like 3
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEA5 melanoma antigen family A5
MAPK10 mitogen-activated protein kinase 10
MATK megakaryocyte-associated tyrosine kinase
MTCP1 mature T-cell proliferation 1
MYO1D myosin ID
NOL10 nucleolar protein 10
ONECUT2 one cut homeobox 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PDIA3 protein disulfide isomerase family A, member 3
PHF14 PHD finger protein 14
POLM polymerase (DNA directed), mu
POM121 POM121 transmembrane nucleoporin
PRKCE protein kinase C, epsilon
RANBP17 RAN binding protein 17
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RIC8B RIC8 guanine nucleotide exchange factor B
RNF39 ring finger protein 39
RPAP2 RNA polymerase II associated protein 2
RPL10L ribosomal protein L10-like
SCN1B sodium channel, voltage gated, type I beta subunit
SECTM1 secreted and transmembrane 1
SLC12A9 solute carrier family 12, member 9
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLMO1 slowmo homolog 1 (Drosophila)
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
STRA6 stimulated by retinoic acid 6
TAOK1 TAO kinase 1
TBC1D19 TBC1 domain family, member 19
TBC1D2 TBC1 domain family, member 2
THRAP3 thyroid hormone receptor associated protein 3
TLR5 toll-like receptor 5
TMEM53 transmembrane protein 53
TMPRSS4 transmembrane protease, serine 4
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM68 tripartite motif containing 68
TTC23 tetratricopeptide repeat domain 23
VGF VGF nerve growth factor inducible
VPS9D1 VPS9 domain containing 1
WDR25 WD repeat domain 25
WDR78 WD repeat domain 78
WDR82 WD repeat domain 82
ZBTB48 zinc finger and BTB domain containing 48
ZBTB6 zinc finger and BTB domain containing 6
ZFHX2 zinc finger homeobox 2
ZNF141 zinc finger protein 141
ZNF532 zinc finger protein 532