nifedipine-6006 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the nifedipine-6006 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ADARB1 adenosine deaminase, RNA-specific, B1
AHNAK2 AHNAK nucleoprotein 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGAP25 Rho GTPase activating protein 25
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASMT acetylserotonin O-methyltransferase
ATP10B ATPase, class V, type 10B
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CD52 CD52 molecule
CD58 CD58 molecule
CGA glycoprotein hormones, alpha polypeptide
CIB2 calcium and integrin binding family member 2
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
DNASE1L2 deoxyribonuclease I-like 2
DRD2 dopamine receptor D2
DUSP13 dual specificity phosphatase 13
EDN3 endothelin 3
EGFR epidermal growth factor receptor
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EPHX2 epoxide hydrolase 2, cytoplasmic
FGF6 fibroblast growth factor 6
FN1 fibronectin 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GLS glutaminase
GPR137 G protein-coupled receptor 137
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HFE hemochromatosis
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGLV3-19 immunoglobulin lambda variable 3-19
IL17RC interleukin 17 receptor C
IL4R interleukin 4 receptor
IRF4 interferon regulatory factor 4
ITGB7 integrin, beta 7
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF1C kinesin family member 1C
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LEFTY1 left-right determination factor 1
LTBP4 latent transforming growth factor beta binding protein 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARK4 MAP/microtubule affinity-regulating kinase 4
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MED16 mediator complex subunit 16
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MIIP migration and invasion inhibitory protein
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MXD4 MAX dimerization protein 4
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCR2 natural cytotoxicity triggering receptor 2
NTF3 neurotrophin 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR3A2 olfactory receptor, family 3, subfamily A, member 2
OSBPL3 oxysterol binding protein-like 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHB13 protocadherin beta 13
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PGAM2 phosphoglycerate mutase 2 (muscle)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PODNL1 podocan-like 1
POFUT1 protein O-fucosyltransferase 1
POU2F2 POU class 2 homeobox 2
PPARA peroxisome proliferator-activated receptor alpha
PRDM2 PR domain containing 2, with ZNF domain
PTCRA pre T-cell antigen receptor alpha
PTPRJ protein tyrosine phosphatase, receptor type, J
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RB1 retinoblastoma 1
RUNX1 runt-related transcription factor 1
SBNO1 strawberry notch homolog 1 (Drosophila)
SFTPD surfactant protein D
SH3PXD2A SH3 and PX domains 2A
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG8 sperm associated antigen 8
SYNPO2L synaptopodin 2-like
TBKBP1 TBK1 binding protein 1
TBX2 T-box 2
TCHH trichohyalin
TM2D1 TM2 domain containing 1
TMPRSS15 transmembrane protease, serine 15
TRD T cell receptor delta locus
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSKS testis-specific serine kinase substrate
TTC12 tetratricopeptide repeat domain 12
WIZ widely interspaced zinc finger motifs
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADGRG2 adhesion G protein-coupled receptor G2
ALPK1 alpha-kinase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AUH AU RNA binding protein/enoyl-CoA hydratase
BATF basic leucine zipper transcription factor, ATF-like
BMP4 bone morphogenetic protein 4
C5AR2 complement component 5a receptor 2
CADPS2 Ca++-dependent secretion activator 2
CD302 CD302 molecule
CHML choroideremia-like (Rab escort protein 2)
CHST10 carbohydrate sulfotransferase 10
CORT cortistatin
CRIP1 cysteine-rich protein 1 (intestinal)
CRY1 cryptochrome circadian clock 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
FAM131A family with sequence similarity 131, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GLB1L2 galactosidase, beta 1-like 2
GPR19 G protein-coupled receptor 19
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AJ histone cluster 1, H2aj
HIST1H4D histone cluster 1, H4d
HSPA2 heat shock 70kDa protein 2
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFT81 intraflagellar transport 81
IL17RA interleukin 17 receptor A
IQSEC2 IQ motif and Sec7 domain 2
IRF9 interferon regulatory factor 9
ITPKB inositol-trisphosphate 3-kinase B
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KLHL2 kelch-like family member 2
LIG4 ligase IV, DNA, ATP-dependent
LIN7B lin-7 homolog B (C. elegans)
LINC00115 long intergenic non-protein coding RNA 115
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEF1 melanoma antigen family F1
MAMLD1 mastermind-like domain containing 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MFAP2 microfibrillar-associated protein 2
MITF microphthalmia-associated transcription factor
MNS1 meiosis-specific nuclear structural 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYL5 myosin, light chain 5, regulatory
MYO1F myosin IF
NACA2 nascent polypeptide-associated complex alpha subunit 2
NIPAL2 NIPA-like domain containing 2
NXPH4 neurexophilin 4
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PDE12 phosphodiesterase 12
PFDN1 prefoldin subunit 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PMCH pro-melanin-concentrating hormone
PMP22 peripheral myelin protein 22
PODXL podocalyxin-like
POMT2 protein-O-mannosyltransferase 2
PRPH peripherin
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAB30 RAB30, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RANBP17 RAN binding protein 17
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPGR retinitis pigmentosa GTPase regulator
S100A4 S100 calcium binding protein A4
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SGK1 serum/glucocorticoid regulated kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPIDR scaffolding protein involved in DNA repair
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRY2 sprouty homolog 2 (Drosophila)
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TASP1 taspase, threonine aspartase, 1
THBS3 thrombospondin 3
THOP1 thimet oligopeptidase 1
TMEM104 transmembrane protein 104
TMEM209 transmembrane protein 209
TRABD TraB domain containing
TRAF2 TNF receptor-associated factor 2
TTBK2 tau tubulin kinase 2
TUBA3D tubulin, alpha 3d
ULBP2 UL16 binding protein 2
UNC119 unc-119 homolog (C. elegans)
USP18 ubiquitin specific peptidase 18
WDR91 WD repeat domain 91
XK X-linked Kx blood group
ZFP30 ZFP30 zinc finger protein
ZFP37 ZFP37 zinc finger protein
ZFP69B ZFP69 zinc finger protein B
ZNF573 zinc finger protein 573
ZNF665 zinc finger protein 665