nifuroxazide-4253 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the nifuroxazide-4253 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
AAMDC adipogenesis associated, Mth938 domain containing
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADAP2 ArfGAP with dual PH domains 2
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOH apolipoprotein H (beta-2-glycoprotein I)
ARHGAP22 Rho GTPase activating protein 22
BGLAP bone gamma-carboxyglutamate (gla) protein
C14ORF93 chromosome 14 open reading frame 93
C21ORF2 chromosome 21 open reading frame 2
CD209 CD209 molecule
CD33 CD33 molecule
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CLCA2 chloride channel accessory 2
CNTNAP2 contactin associated protein-like 2
COL6A1 collagen, type VI, alpha 1
CRTC1 CREB regulated transcription coactivator 1
CSN3 casein kappa
CYSLTR1 cysteinyl leukotriene receptor 1
DCTN1 dynactin 1
DCTN2 dynactin 2 (p50)
DGKA diacylglycerol kinase, alpha 80kDa
DHRS12 dehydrogenase/reductase (SDR family) member 12
DOK4 docking protein 4
DRD2 dopamine receptor D2
DSTYK dual serine/threonine and tyrosine protein kinase
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EBF2 early B-cell factor 2
EFNA5 ephrin-A5
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPHB2 EPH receptor B2
EPYC epiphycan
FAS Fas cell surface death receptor
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FOXN3 forkhead box N3
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HMOX1 heme oxygenase 1
HOXB1 homeobox B1
HOXB3 homeobox B3
HOXC11 homeobox C11
HRASLS HRAS-like suppressor
IGFBP1 insulin-like growth factor binding protein 1
ITGB8 integrin, beta 8
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
KCNK12 potassium channel, two pore domain subfamily K, member 12
KDSR 3-ketodihydrosphingosine reductase
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF4 Kruppel-like factor 4 (gut)
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LYPD3 LY6/PLAUR domain containing 3
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAPK8 mitogen-activated protein kinase 8
MBL2 mannose-binding lectin (protein C) 2, soluble
NDOR1 NADPH dependent diflavin oxidoreductase 1
NEU3 sialidase 3 (membrane sialidase)
NIPAL2 NIPA-like domain containing 2
NPR1 natriuretic peptide receptor 1
NPTX1 neuronal pentraxin I
NPY5R neuropeptide Y receptor Y5
NUP54 nucleoporin 54kDa
OR2H2 olfactory receptor, family 2, subfamily H, member 2
ORC5 origin recognition complex, subunit 5
OSGIN1 oxidative stress induced growth inhibitor 1
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PITX2 paired-like homeodomain 2
PLXDC1 plexin domain containing 1
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PON1 paraoxonase 1
PPARD peroxisome proliferator-activated receptor delta
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP4R4 protein phosphatase 4, regulatory subunit 4
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RNF17 ring finger protein 17
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELL selectin L
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC35F5 solute carrier family 35, member F5
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SOCS3 suppressor of cytokine signaling 3
SPINK5 serine peptidase inhibitor, Kazal type 5
SPP1 secreted phosphoprotein 1
TENM1 teneurin transmembrane protein 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFEB transcription factor EB
THPO thrombopoietin
TNXB tenascin XB
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TRIM3 tripartite motif containing 3
VCL vinculin
ZFP64 ZFP64 zinc finger protein
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADAM2 ADAM metallopeptidase domain 2
ALOX12 arachidonate 12-lipoxygenase
ANGPT4 angiopoietin 4
ANKFY1 ankyrin repeat and FYVE domain containing 1
ATAD5 ATPase family, AAA domain containing 5
BIRC3 baculoviral IAP repeat containing 3
BTC betacellulin
C1RL complement component 1, r subcomponent-like
C5ORF42 chromosome 5 open reading frame 42
C7ORF69 chromosome 7 open reading frame 69
CD82 CD82 molecule
CDHR2 cadherin-related family member 2
CES3 carboxylesterase 3
CIDEB cell death-inducing DFFA-like effector b
CLEC16A C-type lectin domain family 16, member A
CORO2A coronin, actin binding protein, 2A
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXORF21 chromosome X open reading frame 21
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
EDN1 endothelin 1
EGOT eosinophil granule ontogeny transcript (non-protein coding)
ERO1LB ERO1-like beta (S. cerevisiae)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM105A family with sequence similarity 105, member A
FBRS fibrosin
FGF20 fibroblast growth factor 20
FKBP5 FK506 binding protein 5
FRMPD1 FERM and PDZ domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FURIN furin (paired basic amino acid cleaving enzyme)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GIF gastric intrinsic factor (vitamin B synthesis)
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
HIST1H1D histone cluster 1, H1d
HIST1H3A histone cluster 1, H3a
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
IGKV3-20 immunoglobulin kappa variable 3-20
IL1B interleukin 1, beta
IL24 interleukin 24
IL36RN interleukin 36 receptor antagonist
ITPKA inositol-trisphosphate 3-kinase A
JAM3 junctional adhesion molecule 3
KANSL3 KAT8 regulatory NSL complex subunit 3
KIF13A kinesin family member 13A
KLF13 Kruppel-like factor 13
KLHL25 kelch-like family member 25
LATS1 large tumor suppressor kinase 1
LIG4 ligase IV, DNA, ATP-dependent
LIME1 Lck interacting transmembrane adaptor 1
LINC00115 long intergenic non-protein coding RNA 115
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC100287590 uncharacterized LOC100287590
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6G6C lymphocyte antigen 6 complex, locus G6C
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MEIS1 Meis homeobox 1
MFGE8 milk fat globule-EGF factor 8 protein
MTSS1L metastasis suppressor 1-like
NOTCH4 notch 4
NPFFR1 neuropeptide FF receptor 1
PARP6 poly (ADP-ribose) polymerase family, member 6
PHEX phosphate regulating endopeptidase homolog, X-linked
PLD2 phospholipase D2
PRB3 proline-rich protein BstNI subfamily 3
PRKG2 protein kinase, cGMP-dependent, type II
PRM2 protamine 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXMP4 peroxisomal membrane protein 4, 24kDa
RAB40A RAB40A, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGS19 regulator of G-protein signaling 19
RNF122 ring finger protein 122
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC22A18 solute carrier family 22, member 18
STAB2 stabilin 2
STAG3 stromal antigen 3
TENM4 teneurin transmembrane protein 4
TEX15 testis expressed 15
TLN2 talin 2
TLR2 toll-like receptor 2
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAC T cell receptor alpha constant
TSPAN8 tetraspanin 8
TTLL1 tubulin tyrosine ligase-like family member 1
ZBTB22 zinc finger and BTB domain containing 22
ZNF253 zinc finger protein 253
ZNF280B zinc finger protein 280B
ZNF286A zinc finger protein 286A
ZNF480 zinc finger protein 480
ZNF510 zinc finger protein 510
ZNF528 zinc finger protein 528