nimesulide-2275 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the nimesulide-2275 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADGB androglobin
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATF7 activating transcription factor 7
ATM ATM serine/threonine kinase
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BST2 bone marrow stromal cell antigen 2
BTBD7 BTB (POZ) domain containing 7
C10ORF10 chromosome 10 open reading frame 10
C4ORF29 chromosome 4 open reading frame 29
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCDC57 coiled-coil domain containing 57
CD1E CD1e molecule
CDRT1 CMT1A duplicated region transcript 1
CFLAR CASP8 and FADD-like apoptosis regulator
COL14A1 collagen, type XIV, alpha 1
CPA2 carboxypeptidase A2 (pancreatic)
CRTC1 CREB regulated transcription coactivator 1
DMXL2 Dmx-like 2
DNM3 dynamin 3
DSC2 desmocollin 2
EPHB1 EPH receptor B1
ESR1 estrogen receptor 1
ETV5 ets variant 5
ETV7 ets variant 7
FAM49B family with sequence similarity 49, member B
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FKRP fukutin related protein
GPER1 G protein-coupled estrogen receptor 1
GSK3A glycogen synthase kinase 3 alpha
HFE hemochromatosis
HGFAC HGF activator
HNRNPM heterogeneous nuclear ribonucleoprotein M
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI2-AS1 IDI2 antisense RNA 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IHH indian hedgehog
ISG15 ISG15 ubiquitin-like modifier
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
LEFTY2 left-right determination factor 2
LGALS2 lectin, galactoside-binding, soluble, 2
LRRC1 leucine rich repeat containing 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MC5R melanocortin 5 receptor
MED18 mediator complex subunit 18
MEF2D myocyte enhancer factor 2D
MIER2 mesoderm induction early response 1, family member 2
MYH11 myosin, heavy chain 11, smooth muscle
MYO1B myosin IB
NCKIPSD NCK interacting protein with SH3 domain
NMT2 N-myristoyltransferase 2
NOD2 nucleotide-binding oligomerization domain containing 2
NPY2R neuropeptide Y receptor Y2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
ONECUT2 one cut homeobox 2
PAX4 paired box 4
PCNX pecanex homolog (Drosophila)
PHF20L1 PHD finger protein 20-like 1
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRKG2 protein kinase, cGMP-dependent, type II
PSG9 pregnancy specific beta-1-glycoprotein 9
PTCH1 patched 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RFPL3 ret finger protein-like 3
RNF144A ring finger protein 144A
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SFRP4 secreted frizzled-related protein 4
SHOX2 short stature homeobox 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SKIL SKI-like proto-oncogene
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SNX13 sorting nexin 13
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK5 serine peptidase inhibitor, Kazal type 5
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STEAP4 STEAP family member 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYN3 synapsin III
TBX6 T-box 6
TCEAL2 transcription elongation factor A (SII)-like 2
TNMD tenomodulin
TRIM29 tripartite motif containing 29
TRPC1 transient receptor potential cation channel, subfamily C, member 1
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
ZMYND8 zinc finger, MYND-type containing 8
ZNF286A zinc finger protein 286A
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ABLIM3 actin binding LIM protein family, member 3
ALS2CL ALS2 C-terminal like
APOLD1 apolipoprotein L domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BCL9 B-cell CLL/lymphoma 9
C11ORF80 chromosome 11 open reading frame 80
CD80 CD80 molecule
CD82 CD82 molecule
CD83 CD83 molecule
CDK18 cyclin-dependent kinase 18
CLDN15 claudin 15
CNTN1 contactin 1
CRIP1 cysteine-rich protein 1 (intestinal)
CUZD1 CUB and zona pellucida-like domains 1
DGAT1 diacylglycerol O-acyltransferase 1
DMTN dematin actin binding protein
DNAH17 dynein, axonemal, heavy chain 17
DNALI1 dynein, axonemal, light intermediate chain 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
FAM76A family with sequence similarity 76, member A
FKBP10 FK506 binding protein 10, 65 kDa
FOXN2 forkhead box N2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG3 guanine nucleotide binding protein (G protein), gamma 3
HLA-J major histocompatibility complex, class I, J (pseudogene)
HP1BP3 heterochromatin protein 1, binding protein 3
INPP5J inositol polyphosphate-5-phosphatase J
ITGA10 integrin, alpha 10
ITPKB inositol-trisphosphate 3-kinase B
JPH3 junctophilin 3
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA0319L KIAA0319-like
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHDC8A kelch domain containing 8A
LHX6 LIM homeobox 6
LIF leukemia inhibitory factor
LTC4S leukotriene C4 synthase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEF1 melanoma antigen family F1
MALL mal, T-cell differentiation protein-like
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBNL3 muscleblind-like splicing regulator 3
MEFV Mediterranean fever
METTL16 methyltransferase like 16
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICALL2 MICAL-like 2
MON1B MON1 secretory trafficking family member B
N4BP3 NEDD4 binding protein 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NBEAL2 neurobeachin-like 2
NDE1 nudE neurodevelopment protein 1
NOL12 nucleolar protein 12
NPM3 nucleophosmin/nucleoplasmin 3
OLFML2A olfactomedin-like 2A
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCD1 phospholipase C, delta 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PSKH1 protein serine kinase H1
PYHIN1 pyrin and HIN domain family, member 1
RCAN3 RCAN family member 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SDC3 syndecan 3
SH2D4A SH2 domain containing 4A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLIT2 slit homolog 2 (Drosophila)
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPTBN2 spectrin, beta, non-erythrocytic 2
SRD5A3 steroid 5 alpha-reductase 3
STMN3 stathmin-like 3
TCP10 t-complex 10
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
UBXN6 UBX domain protein 6
UNC119 unc-119 homolog (C. elegans)
USP20 ubiquitin specific peptidase 20
VGF VGF nerve growth factor inducible
WDR62 WD repeat domain 62
WDR91 WD repeat domain 91
WLS wntless Wnt ligand secretion mediator
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF37BP zinc finger protein 37B, pseudogene
ZNF552 zinc finger protein 552
ZNF821 zinc finger protein 821
ZNF862 zinc finger protein 862