nipecotic acid-6500 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the nipecotic acid-6500 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX1 acyl-CoA oxidase 1, palmitoyl
AGMAT agmatine ureohydrolase (agmatinase)
AK2 adenylate kinase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALS2CL ALS2 C-terminal like
AMACR alpha-methylacyl-CoA racemase
AMBP alpha-1-microglobulin/bikunin precursor
ATN1 atrophin 1
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCL2 B-cell CLL/lymphoma 2
BTF3P11 basic transcription factor 3 pseudogene 11
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CA4 carbonic anhydrase IV
CALB2 calbindin 2
CASC1 cancer susceptibility candidate 1
CD6 CD6 molecule
CDC25C cell division cycle 25C
CDK13 cyclin-dependent kinase 13
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
COL1A2 collagen, type I, alpha 2
CXADR coxsackie virus and adenovirus receptor
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
EPO erythropoietin
FABP3 fatty acid binding protein 3, muscle and heart
FABP6 fatty acid binding protein 6, ileal
FGF20 fibroblast growth factor 20
FGFR4 fibroblast growth factor receptor 4
FNDC3A fibronectin type III domain containing 3A
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GSK3A glycogen synthase kinase 3 alpha
HHAT hedgehog acyltransferase
HIST1H1T histone cluster 1, H1t
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HP1BP3 heterochromatin protein 1, binding protein 3
ICOSLG inducible T-cell co-stimulator ligand
IGHMBP2 immunoglobulin mu binding protein 2
IPO8 importin 8
ITGA10 integrin, alpha 10
JPH3 junctophilin 3
KANK1 KN motif and ankyrin repeat domains 1
KIF25 kinesin family member 25
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LDB3 LIM domain binding 3
LMF2 lipase maturation factor 2
LRRC48 leucine rich repeat containing 48
MAP2K5 mitogen-activated protein kinase kinase 5
MATK megakaryocyte-associated tyrosine kinase
MAX MYC associated factor X
MBD2 methyl-CpG binding domain protein 2
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MST1 macrophage stimulating 1
MTA1 metastasis associated 1
NABP1 nucleic acid binding protein 1
NKX2-5 NK2 homeobox 5
NOX1 NADPH oxidase 1
NPY4R neuropeptide Y receptor Y4
NREP neuronal regeneration related protein
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PAX2 paired box 2
PCDHGB5 protocadherin gamma subfamily B, 5
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PLCE1 phospholipase C, epsilon 1
PMFBP1 polyamine modulated factor 1 binding protein 1
POLL polymerase (DNA directed), lambda
PON1 paraoxonase 1
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PTPRD protein tyrosine phosphatase, receptor type, D
RAB11B RAB11B, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASIP1 Ras interacting protein 1
RCAN1 regulator of calcineurin 1
RIC3 RIC3 acetylcholine receptor chaperone
RIMS1 regulating synaptic membrane exocytosis 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
SCAPER S-phase cyclin A-associated protein in the ER
SCN11A sodium channel, voltage gated, type XI alpha subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC25A30 solute carrier family 25, member 30
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STX7 syntaxin 7
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TBC1D5 TBC1 domain family, member 5
TBCD tubulin folding cofactor D
THAP3 THAP domain containing, apoptosis associated protein 3
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
USB1 U6 snRNA biogenesis 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR76 WD repeat domain 76
WIPI2 WD repeat domain, phosphoinositide interacting 2
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
AFAP1 actin filament associated protein 1
APLP1 amyloid beta (A4) precursor-like protein 1
ATP11B ATPase, class VI, type 11B
AUTS2 autism susceptibility candidate 2
C8ORF60 chromosome 8 open reading frame 60
CCDC85C coiled-coil domain containing 85C
CD82 CD82 molecule
CEP70 centrosomal protein 70kDa
CLCF1 cardiotrophin-like cytokine factor 1
CLDND1 claudin domain containing 1
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COL9A2 collagen, type IX, alpha 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRLF1 cytokine receptor-like factor 1
CTAGE5 CTAGE family, member 5
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DCAF17 DDB1 and CUL4 associated factor 17
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DONSON downstream neighbor of SON
DSCAM Down syndrome cell adhesion molecule
DUSP2 dual specificity phosphatase 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC6 excision repair cross-complementation group 6
F3 coagulation factor III (thromboplastin, tissue factor)
FAM110B family with sequence similarity 110, member B
FAM155A family with sequence similarity 155, member A
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GPX2 glutathione peroxidase 2
GRPR gastrin-releasing peptide receptor
HIST1H4F histone cluster 1, H4f
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA4 homeobox A4
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL4R interleukin 4 receptor
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUNB jun B proto-oncogene
KIFC1 kinesin family member C1
KLF11 Kruppel-like factor 11
KLHL28 kelch-like family member 28
KLHL36 kelch-like family member 36
LAMA3 laminin, alpha 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LENEP lens epithelial protein
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRP2 low density lipoprotein receptor-related protein 2
LRRC20 leucine rich repeat containing 20
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MB myoglobin
MMP2 matrix metallopeptidase 2
MORC3 MORC family CW-type zinc finger 3
MXD3 MAX dimerization protein 3
NECAP2 NECAP endocytosis associated 2
NPFFR1 neuropeptide FF receptor 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUP62CL nucleoporin 62kDa C-terminal like
NUPL2 nucleoporin like 2
PACS1 phosphofurin acidic cluster sorting protein 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB36 RAB36, member RAS oncogene family
RASA2 RAS p21 protein activator 2
RNF126P1 ring finger protein 126 pseudogene 1
RNF31 ring finger protein 31
SAYSD1 SAYSVFN motif domain containing 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPIDR scaffolding protein involved in DNA repair
STEAP3 STEAP family member 3, metalloreductase
STON1 stonin 1
SYCP2 synaptonemal complex protein 2
TAOK1 TAO kinase 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TPCN1 two pore segment channel 1
TRIM5 tripartite motif containing 5
TUBA3D tubulin, alpha 3d
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UPK3B uroplakin 3B
VASH2 vasohibin 2
VGF VGF nerve growth factor inducible
VIM vimentin
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF16 zinc finger protein 16
ZNF212 zinc finger protein 212
ZNF219 zinc finger protein 219
ZNF365 zinc finger protein 365
ZNF668 zinc finger protein 668