nitrendipine-5405 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the nitrendipine-5405 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADCK2 aarF domain containing kinase 2
AFAP1 actin filament associated protein 1
AFF4 AF4/FMR2 family, member 4
AK2 adenylate kinase 2
ALS2CL ALS2 C-terminal like
ANAPC13 anaphase promoting complex subunit 13
ANKRD7 ankyrin repeat domain 7
ARC activity-regulated cytoskeleton-associated protein
AREG amphiregulin
ARTN artemin
ASPH aspartate beta-hydroxylase
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BMP1 bone morphogenetic protein 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C18ORF25 chromosome 18 open reading frame 25
CALML5 calmodulin-like 5
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CD6 CD6 molecule
CDC14B cell division cycle 14B
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CLEC11A C-type lectin domain family 11, member A
COL11A2 collagen, type XI, alpha 2
CREBZF CREB/ATF bZIP transcription factor
CSHL1 chorionic somatomammotropin hormone-like 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DOCK6 dedicator of cytokinesis 6
DOK5 docking protein 5
DTNA dystrobrevin, alpha
EGR3 early growth response 3
FBXO2 F-box protein 2
FHIT fragile histidine triad
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPR137 G protein-coupled receptor 137
GSPT2 G1 to S phase transition 2
HDAC11 histone deacetylase 11
HFE hemochromatosis
HGD homogentisate 1,2-dioxygenase
ICOSLG inducible T-cell co-stimulator ligand
IDUA iduronidase, alpha-L-
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAK2 Janus kinase 2
JMJD4 jumonji domain containing 4
KIAA0125 KIAA0125
KLHL22 kelch-like family member 22
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCTP1 multiple C2 domains, transmembrane 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MST1 macrophage stimulating 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYEF2 myelin expression factor 2
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NAV2 neuron navigator 2
NPC1 Niemann-Pick disease, type C1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NXPH4 neurexophilin 4
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PCDH17 protocadherin 17
PCNX pecanex homolog (Drosophila)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDLIM5 PDZ and LIM domain 5
PHC1 polyhomeotic homolog 1 (Drosophila)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLK4 polo-like kinase 4
PQLC2 PQ loop repeat containing 2
PRKCI protein kinase C, iota
RAB30 RAB30, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASEH2B ribonuclease H2, subunit B
RPL10L ribosomal protein L10-like
S100A11 S100 calcium binding protein A11
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SALL1 spalt-like transcription factor 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SFTPB surfactant protein B
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SOS2 son of sevenless homolog 2 (Drosophila)
SYBU syntabulin (syntaxin-interacting)
TBC1D2B TBC1 domain family, member 2B
TGFA transforming growth factor, alpha
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TOP3B topoisomerase (DNA) III beta
TPMT thiopurine S-methyltransferase
TTC38 tetratricopeptide repeat domain 38
UROD uroporphyrinogen decarboxylase
VN1R1 vomeronasal 1 receptor 1

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AEBP1 AE binding protein 1
AHDC1 AT hook, DNA binding motif, containing 1
APLP1 amyloid beta (A4) precursor-like protein 1
APOD apolipoprotein D
BLNK B-cell linker
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTF3P12 basic transcription factor 3 pseudogene 12
C19ORF73 chromosome 19 open reading frame 73
CAMK1 calcium/calmodulin-dependent protein kinase I
CD79B CD79b molecule, immunoglobulin-associated beta
CIC capicua transcriptional repressor
CLIC2 chloride intracellular channel 2
CLSPN claspin
CNGB3 cyclic nucleotide gated channel beta 3
CPTP ceramide-1-phosphate transfer protein
CTSF cathepsin F
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DGAT1 diacylglycerol O-acyltransferase 1
DNAH17 dynein, axonemal, heavy chain 17
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
ETNK2 ethanolamine kinase 2
ETV6 ets variant 6
EXO5 exonuclease 5
FAM53B family with sequence similarity 53, member B
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLT4 fms-related tyrosine kinase 4
FURIN furin (paired basic amino acid cleaving enzyme)
GADD45G growth arrest and DNA-damage-inducible, gamma
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GMEB1 glucocorticoid modulatory element binding protein 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H1D histone cluster 1, H1d
HIST1H4E histone cluster 1, H4e
HOXC10 homeobox C10
HP1BP3 heterochromatin protein 1, binding protein 3
IFI6 interferon, alpha-inducible protein 6
IFT54 intraflagellar transport 54
IGFBP6 insulin-like growth factor binding protein 6
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
ISG15 ISG15 ubiquitin-like modifier
KLK5 kallikrein-related peptidase 5
LAMB3 laminin, beta 3
LRP2 low density lipoprotein receptor-related protein 2
LRRC8E leucine rich repeat containing 8 family, member E
MAGEH1 melanoma antigen family H1
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MTA2 metastasis associated 1 family, member 2
MYOZ3 myozenin 3
NDE1 nudE neurodevelopment protein 1
NDOR1 NADPH dependent diflavin oxidoreductase 1
NEK11 NIMA-related kinase 11
NUAK1 NUAK family, SNF1-like kinase, 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
OLFML2A olfactomedin-like 2A
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAQR6 progestin and adipoQ receptor family member VI
PCDHGB5 protocadherin gamma subfamily B, 5
PDE12 phosphodiesterase 12
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PITX2 paired-like homeodomain 2
QPCT glutaminyl-peptide cyclotransferase
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RNF43 ring finger protein 43
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUNDC3B RUN domain containing 3B
SIK1 salt-inducible kinase 1
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLIT2 slit homolog 2 (Drosophila)
SPTBN5 spectrin, beta, non-erythrocytic 5
SREK1IP1 SREK1-interacting protein 1
ST5 suppression of tumorigenicity 5
STEAP3 STEAP family member 3, metalloreductase
STK16 serine/threonine kinase 16
SYT17 synaptotagmin XVII
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM159 transmembrane protein 159
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TWSG1 twisted gastrulation BMP signaling modulator 1
VASH2 vasohibin 2
VLDLR very low density lipoprotein receptor
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBTB39 zinc finger and BTB domain containing 39
ZFHX3 zinc finger homeobox 3
ZNF137P zinc finger protein 137, pseudogene
ZNF639 zinc finger protein 639
ZNF747 zinc finger protein 747
ZNF804A zinc finger protein 804A