nitrofurantoin-7373 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the nitrofurantoin-7373 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADGRL1 adhesion G protein-coupled receptor L1
ANXA10 annexin A10
APOM apolipoprotein M
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BTG2 BTG family, member 2
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCDC93 coiled-coil domain containing 93
CCNT2 cyclin T2
CDC14B cell division cycle 14B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFLAR CASP8 and FADD-like apoptosis regulator
CHRM3 cholinergic receptor, muscarinic 3
CNTNAP2 contactin associated protein-like 2
CTNND2 catenin (cadherin-associated protein), delta 2
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHRS12 dehydrogenase/reductase (SDR family) member 12
DOHH deoxyhypusine hydroxylase/monooxygenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHBP1L1 EH domain binding protein 1-like 1
EPAS1 endothelial PAS domain protein 1
ERO1LB ERO1-like beta (S. cerevisiae)
EXOC6B exocyst complex component 6B
FCF1 FCF1 rRNA-processing protein
FGFR1 fibroblast growth factor receptor 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GPR161 G protein-coupled receptor 161
GRK5 G protein-coupled receptor kinase 5
HIST1H1E histone cluster 1, H1e
HIST3H3 histone cluster 3, H3
HOXA4 homeobox A4
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL12A interleukin 12A
IL15 interleukin 15
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KITLG KIT ligand
KRTAP9-9 keratin associated protein 9-9
LIG3 ligase III, DNA, ATP-dependent
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEH1 melanoma antigen family H1
MED31 mediator complex subunit 31
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MMP13 matrix metallopeptidase 13
MRPL57 mitochondrial ribosomal protein L57
MYO7A myosin VIIA
MYOZ3 myozenin 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OAZ3 ornithine decarboxylase antizyme 3
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCOLCE procollagen C-endopeptidase enhancer
PGAP1 post-GPI attachment to proteins 1
PGM5 phosphoglucomutase 5
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTBP3 polypyrimidine tract binding protein 3
PTGDR2 prostaglandin D2 receptor 2
PVT1 Pvt1 oncogene (non-protein coding)
RAB31 RAB31, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RARG retinoic acid receptor, gamma
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RGS7 regulator of G-protein signaling 7
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPAP2 RNA polymerase II associated protein 2
SAMD4B sterile alpha motif domain containing 4B
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SENP6 SUMO1/sentrin specific peptidase 6
SERBP1 SERPINE1 mRNA binding protein 1
SERTAD3 SERTA domain containing 3
SIRT3 sirtuin 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOX30 SRY (sex determining region Y)-box 30
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STARD3 StAR-related lipid transfer (START) domain containing 3
SYN2 synapsin II
TBCD tubulin folding cofactor D
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TLE4 transducin-like enhancer of split 4
TMCO6 transmembrane and coiled-coil domains 6
TRAV8-3 T cell receptor alpha variable 8-3
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TYRO3 TYRO3 protein tyrosine kinase
ULK2 unc-51 like autophagy activating kinase 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
XYLB xylulokinase homolog (H. influenzae)
YTHDC1 YTH domain containing 1
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF768 zinc finger protein 768

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANG angiogenin, ribonuclease, RNase A family, 5
ARHGAP12 Rho GTPase activating protein 12
ARMC6 armadillo repeat containing 6
ASCC2 activating signal cointegrator 1 complex subunit 2
ATAD2B ATPase family, AAA domain containing 2B
ATOX1 antioxidant 1 copper chaperone
BAG4 BCL2-associated athanogene 4
C9ORF91 chromosome 9 open reading frame 91
CAPN5 calpain 5
CCDC106 coiled-coil domain containing 106
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDH7 cadherin 7, type 2
CLDN15 claudin 15
CLEC10A C-type lectin domain family 10, member A
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSK cathepsin K
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYB5R1 cytochrome b5 reductase 1
DCAF13 DDB1 and CUL4 associated factor 13
DDIT4 DNA-damage-inducible transcript 4
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EDC3 enhancer of mRNA decapping 3
ELP6 elongator acetyltransferase complex subunit 6
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV4 ets variant 4
FAM102A family with sequence similarity 102, member A
FBXO5 F-box protein 5
FCHO1 FCH domain only 1
FSD1 fibronectin type III and SPRY domain containing 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GLDC glycine dehydrogenase (decarboxylating)
GRPR gastrin-releasing peptide receptor
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HIST1H2AJ histone cluster 1, H2aj
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IREB2 iron-responsive element binding protein 2
KIF16B kinesin family member 16B
LIMS2 LIM and senescent cell antigen-like domains 2
LNPEP leucyl/cystinyl aminopeptidase
LPAR3 lysophosphatidic acid receptor 3
LY6G5C lymphocyte antigen 6 complex, locus G5C
LYRM2 LYR motif containing 2
MACROD1 MACRO domain containing 1
MAST3 microtubule associated serine/threonine kinase 3
MBIP MAP3K12 binding inhibitory protein 1
MCC mutated in colorectal cancers
MFGE8 milk fat globule-EGF factor 8 protein
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MYL5 myosin, light chain 5, regulatory
MYO1D myosin ID
NABP2 nucleic acid binding protein 2
NCS1 neuronal calcium sensor 1
NECAP2 NECAP endocytosis associated 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PLCD1 phospholipase C, delta 1
PRPF8 pre-mRNA processing factor 8
PRR7 proline rich 7 (synaptic)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RANBP17 RAN binding protein 17
RBM47 RNA binding motif protein 47
REV1 REV1, polymerase (DNA directed)
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RHOC ras homolog family member C
RNF170 ring finger protein 170
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
S100A9 S100 calcium binding protein A9
SAMD9 sterile alpha motif domain containing 9
SCEL sciellin
SEPP1 selenoprotein P, plasma, 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A40 solute carrier family 25, member 40
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SYTL2 synaptotagmin-like 2
TBX19 T-box 19
TLR2 toll-like receptor 2
TMC7 transmembrane channel-like 7
TMEM2 transmembrane protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC2 trafficking protein particle complex 2
TRIM9 tripartite motif containing 9
TSPAN15 tetraspanin 15
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR76 WD repeat domain 76
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZBTB44 zinc finger and BTB domain containing 44
ZMAT5 zinc finger, matrin-type 5
ZNF282 zinc finger protein 282
ZNF34 zinc finger protein 34
ZNF480 zinc finger protein 480
ZNF552 zinc finger protein 552
ZNF668 zinc finger protein 668