nlrp3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description NLR family, pyrin domain containing 3|This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 114548)
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Genes

70 genes co-occuring with the biological term nlrp3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AIM2 absent in melanoma 2
APOE apolipoprotein E
CAMP cathelicidin antimicrobial peptide
CARD8 caspase recruitment domain family, member 8
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CD36 CD36 molecule (thrombospondin receptor)
CLEC5A C-type lectin domain family 5, member A
CLEC7A C-type lectin domain family 7, member A
CTSB cathepsin B
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33
DICER1 dicer 1, ribonuclease type III
DNM1L dynamin 1-like
EDN1 endothelin 1
FSTL1 follistatin-like 1
GBP5 guanylate binding protein 5
GPRC6A G protein-coupled receptor, class C, group 6, member A
GPSM3 G-protein signaling modulator 3
HCAR1 hydroxycarboxylic acid receptor 1
IFI16 interferon, gamma-inducible protein 16
IFIH1 interferon induced with helicase C domain 1
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL37 interleukin 37
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK8 mitogen-activated protein kinase 8
MAVS mitochondrial antiviral signaling protein
MEFV Mediterranean fever
MIR146A microRNA 146a
MIR223 microRNA 223
MVK mevalonate kinase
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRC4 NLR family, CARD domain containing 4
NLRC5 NLR family, CARD domain containing 5
NLRP1 NLR family, pyrin domain containing 1
NLRP2 NLR family, pyrin domain containing 2
NLRP3 NLR family, pyrin domain containing 3
NLRP6 NLR family, pyrin domain containing 6
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOX1 NADPH oxidase 1
NOX4 NADPH oxidase 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PML promyelocytic leukemia
PYCARD PYD and CARD domain containing
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAA1 serum amyloid A1
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SYK spleen tyrosine kinase
TLR2 toll-like receptor 2
TLR8 toll-like receptor 8
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UMOD uromodulin