nomegestrol-5461 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the nomegestrol-5461 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACRV1 acrosomal vesicle protein 1
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AFF3 AF4/FMR2 family, member 3
ALOXE3 arachidonate lipoxygenase 3
ANTXR1 anthrax toxin receptor 1
BAIAP3 BAI1-associated protein 3
BMP2K BMP2 inducible kinase
C3ORF18 chromosome 3 open reading frame 18
CCDC132 coiled-coil domain containing 132
CFHR4 complement factor H-related 4
CLDN1 claudin 1
CYHR1 cysteine/histidine-rich 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCAF4 DDB1 and CUL4 associated factor 4
DOCK6 dedicator of cytokinesis 6
DRD2 dopamine receptor D2
EGFL7 EGF-like-domain, multiple 7
EPHA1 EPH receptor A1
FAM63B family with sequence similarity 63, member B
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR1 fibroblast growth factor receptor 1
FOXG1 forkhead box G1
FST follistatin
GFI1 growth factor independent 1 transcription repressor
GJB3 gap junction protein, beta 3, 31kDa
GP6 glycoprotein VI (platelet)
GRIP2 glutamate receptor interacting protein 2
GSTTP1 glutathione S-transferase theta pseudogene 1
HIC2 hypermethylated in cancer 2
HOXA2 homeobox A2
HOXB2 homeobox B2
HPGDS hematopoietic prostaglandin D synthase
HRASLS2 HRAS-like suppressor 2
ICA1 islet cell autoantigen 1, 69kDa
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFT54 intraflagellar transport 54
IL1B interleukin 1, beta
IL2 interleukin 2
IQCC IQ motif containing C
IRF2 interferon regulatory factor 2
KDM8 lysine (K)-specific demethylase 8
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMF2 lipase maturation factor 2
MAGEA5 melanoma antigen family A5
MAML3 mastermind-like 3 (Drosophila)
MAP4 microtubule-associated protein 4
MFGE8 milk fat globule-EGF factor 8 protein
NDOR1 NADPH dependent diflavin oxidoreductase 1
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEU3 sialidase 3 (membrane sialidase)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NMT2 N-myristoyltransferase 2
NTF3 neurotrophin 3
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PACS1 phosphofurin acidic cluster sorting protein 1
PGLYRP4 peptidoglycan recognition protein 4
PITX1 paired-like homeodomain 1
PML promyelocytic leukemia
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRB1 proline-rich protein BstNI subfamily 1
PXN paxillin
RANBP3 RAN binding protein 3
RGS12 regulator of G-protein signaling 12
RIMS3 regulating synaptic membrane exocytosis 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPL23AP32 ribosomal protein L23a pseudogene 32
SALL1 spalt-like transcription factor 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEC14L2 SEC14-like 2 (S. cerevisiae)
SFTPB surfactant protein B
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SPEG SPEG complex locus
SPTBN1 spectrin, beta, non-erythrocytic 1
SYNC syncoilin, intermediate filament protein
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TAS2R10 taste receptor, type 2, member 10
TBC1D22A TBC1 domain family, member 22A
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRIL TLR4 interactor with leucine-rich repeats
TRIM22 tripartite motif containing 22
TSPAN9 tetraspanin 9
TTLL4 tubulin tyrosine ligase-like family member 4
TYRP1 tyrosinase-related protein 1
VAC14 Vac14 homolog (S. cerevisiae)
WNK1 WNK lysine deficient protein kinase 1
XIST X inactive specific transcript (non-protein coding)
ZDHHC8P1 zinc finger, DHHC-type containing 8 pseudogene 1
ZIC3 Zic family member 3
ZNF639 zinc finger protein 639
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCK4 aarF domain containing kinase 4
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
BIRC7 baculoviral IAP repeat containing 7
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BST2 bone marrow stromal cell antigen 2
C10ORF95 chromosome 10 open reading frame 95
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAPN15 calpain 15
CCNT1 cyclin T1
CES3 carboxylesterase 3
CLCN6 chloride channel, voltage-sensitive 6
CNGB3 cyclic nucleotide gated channel beta 3
COPZ2 coatomer protein complex, subunit zeta 2
CRELD1 cysteine-rich with EGF-like domains 1
CXXC4 CXXC finger protein 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
DIO1 deiodinase, iodothyronine, type I
DNAH17 dynein, axonemal, heavy chain 17
DSCAM Down syndrome cell adhesion molecule
EFCAB2 EF-hand calcium binding domain 2
ELMO3 engulfment and cell motility 3
ETNK2 ethanolamine kinase 2
EXD3 exonuclease 3'-5' domain containing 3
EXO5 exonuclease 5
FGD1 FYVE, RhoGEF and PH domain containing 1
FLJ11710 uncharacterized protein FLJ11710
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GLRA1 glycine receptor, alpha 1
GPR176 G protein-coupled receptor 176
GPX2 glutathione peroxidase 2
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H1B histone cluster 1, H1b
HIST1H2AJ histone cluster 1, H2aj
HIST1H4C histone cluster 1, H4c
HOXA4 homeobox A4
HOXC13 homeobox C13
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IRF6 interferon regulatory factor 6
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA0754 KIAA0754
KIFC1 kinesin family member C1
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL21 kelch-like family member 21
LAMC3 laminin, gamma 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MCOLN1 mucolipin 1
MRPS18C mitochondrial ribosomal protein S18C
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NES nestin
NRSN2 neurensin 2
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OVOL1 ovo-like zinc finger 1
PDIA3 protein disulfide isomerase family A, member 3
PGR progesterone receptor
PICK1 protein interacting with PRKCA 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLEKHS1 pleckstrin homology domain containing, family S member 1
PRODH proline dehydrogenase (oxidase) 1
PTK6 protein tyrosine kinase 6
RASAL1 RAS protein activator like 1 (GAP1 like)
RHOBTB2 Rho-related BTB domain containing 2
RIN1 Ras and Rab interactor 1
RPGRIP1L RPGRIP1-like
RPL10L ribosomal protein L10-like
RUSC2 RUN and SH3 domain containing 2
S100A9 S100 calcium binding protein A9
SAYSD1 SAYSVFN motif domain containing 1
SCHIP1 schwannomin interacting protein 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SENP7 SUMO1/sentrin specific peptidase 7
SETD8 SET domain containing (lysine methyltransferase) 8
SIX1 SIX homeobox 1
SMA4 glucuronidase, beta pseudogene
SMR3A submaxillary gland androgen regulated protein 3A
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TESC tescalcin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TPCN1 two pore segment channel 1
TTLL1 tubulin tyrosine ligase-like family member 1
UNC119 unc-119 homolog (C. elegans)
VEGFC vascular endothelial growth factor C
VIM vimentin
ZBTB44 zinc finger and BTB domain containing 44
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF16 zinc finger protein 16
ZNF197 zinc finger protein 197
ZNF446 zinc finger protein 446
ZNF813 zinc finger protein 813