nomegestrol-6362 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the nomegestrol-6362 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADGRL1 adhesion G protein-coupled receptor L1
ALG12 ALG12, alpha-1,6-mannosyltransferase
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C17ORF53 chromosome 17 open reading frame 53
C5ORF42 chromosome 5 open reading frame 42
C7ORF43 chromosome 7 open reading frame 43
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CCDC71 coiled-coil domain containing 71
CCNO cyclin O
CCSER2 coiled-coil serine-rich protein 2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDRT1 CMT1A duplicated region transcript 1
CENPJ centromere protein J
COL1A1 collagen, type I, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DST dystonin
E2F5 E2F transcription factor 5, p130-binding
EFNA3 ephrin-A3
EFNB3 ephrin-B3
EMP1 epithelial membrane protein 1
FAM134B family with sequence similarity 134, member B
FAM214B family with sequence similarity 214, member B
FBXO31 F-box protein 31
GAMT guanidinoacetate N-methyltransferase
GHR growth hormone receptor
GPR3 G protein-coupled receptor 3
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HDAC11 histone deacetylase 11
HMOX2 heme oxygenase 2
HOXA1 homeobox A1
HOXB5 homeobox B5
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL11 interleukin 11
ITFG2 integrin alpha FG-GAP repeat containing 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCTD13 potassium channel tetramerization domain containing 13
KIAA1467 KIAA1467
LAMC2 laminin, gamma 2
LDB1 LIM domain binding 1
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRRC8B leucine rich repeat containing 8 family, member B
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAK male germ cell-associated kinase
MINK1 misshapen-like kinase 1
MON1B MON1 secretory trafficking family member B
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NIPAL2 NIPA-like domain containing 2
NMT1 N-myristoyltransferase 1
NOX1 NADPH oxidase 1
NPTXR neuronal pentraxin receptor
NRP2 neuropilin 2
NUMA1 nuclear mitotic apparatus protein 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSBP2 oxysterol binding protein 2
PDE4DIP phosphodiesterase 4D interacting protein
PLCH1 phospholipase C, eta 1
PLD2 phospholipase D2
PLEKHA6 pleckstrin homology domain containing, family A member 6
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRRC2B proline-rich coiled-coil 2B
PTN pleiotrophin
RAD50 RAD50 homolog (S. cerevisiae)
RBMS3 RNA binding motif, single stranded interacting protein 3
RIN3 Ras and Rab interactor 3
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS28 ribosomal protein S28
RUNDC3B RUN domain containing 3B
SAPCD1 suppressor APC domain containing 1
SEC14L4 SEC14-like 4 (S. cerevisiae)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SETDB1 SET domain, bifurcated 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC43A3 solute carrier family 43, member 3
SMG7 SMG7 nonsense mediated mRNA decay factor
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST7L suppression of tumorigenicity 7 like
STBD1 starch binding domain 1
STK17B serine/threonine kinase 17b
STX2 syntaxin 2
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
VWA1 von Willebrand factor A domain containing 1
VWA5A von Willebrand factor A domain containing 5A
YTHDC1 YTH domain containing 1
ZBTB1 zinc finger and BTB domain containing 1
ZMYM2 zinc finger, MYM-type 2
ZNF711 zinc finger protein 711

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAM23 ADAM metallopeptidase domain 23
ADGRG2 adhesion G protein-coupled receptor G2
AGMAT agmatine ureohydrolase (agmatinase)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKRD40 ankyrin repeat domain 40
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ARMC4 armadillo repeat containing 4
ATAD5 ATPase family, AAA domain containing 5
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEX1 brain expressed, X-linked 1
BPHL biphenyl hydrolase-like (serine hydrolase)
C5ORF45 chromosome 5 open reading frame 45
CCNA1 cyclin A1
CDK3 cyclin-dependent kinase 3
CEP72 centrosomal protein 72kDa
CIDEB cell death-inducing DFFA-like effector b
CIR1 corepressor interacting with RBPJ, 1
CORO2A coronin, actin binding protein, 2A
DPF3 D4, zinc and double PHD fingers, family 3
DPH2 DPH2 homolog (S. cerevisiae)
DUSP8 dual specificity phosphatase 8
EGF epidermal growth factor
EGR2 early growth response 2
ETV4 ets variant 4
FBRS fibrosin
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GNL1 guanine nucleotide binding protein-like 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HIST1H3B histone cluster 1, H3b
HOXA6 homeobox A6
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HYAL3 hyaluronoglucosaminidase 3
IRF9 interferon regulatory factor 9
ISYNA1 inositol-3-phosphate synthase 1
KDM5C lysine (K)-specific demethylase 5C
KRT6A keratin 6A, type II
LINC00341 long intergenic non-protein coding RNA 341
LRRC37A3 leucine rich repeat containing 37, member A3
LZTR1 leucine-zipper-like transcription regulator 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK3 mitogen-activated protein kinase 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED15 mediator complex subunit 15
MFSD12 major facilitator superfamily domain containing 12
MRPS18C mitochondrial ribosomal protein S18C
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MX1 MX dynamin-like GTPase 1
MXD3 MAX dimerization protein 3
MYOZ3 myozenin 3
NBEAL2 neurobeachin-like 2
NCS1 neuronal calcium sensor 1
NDRG4 NDRG family member 4
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PC pyruvate carboxylase
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE12 phosphodiesterase 12
PHGDH phosphoglycerate dehydrogenase
PLAG1 pleiomorphic adenoma gene 1
PLCD1 phospholipase C, delta 1
POMT2 protein-O-mannosyltransferase 2
PRSS16 protease, serine, 16 (thymus)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASA2 RAS p21 protein activator 2
RGCC regulator of cell cycle
RIBC2 RIB43A domain with coiled-coils 2
RNF126P1 ring finger protein 126 pseudogene 1
RNF146 ring finger protein 146
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUSC2 RUN and SH3 domain containing 2
SALL2 spalt-like transcription factor 2
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC12A9 solute carrier family 12, member 9
SLC25A40 solute carrier family 25, member 40
SSBP3 single stranded DNA binding protein 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
THBS3 thrombospondin 3
TMEM115 transmembrane protein 115
TMEM62 transmembrane protein 62
TPRA1 transmembrane protein, adipocyte asscociated 1
TRIM9 tripartite motif containing 9
TSC22D4 TSC22 domain family, member 4
TUBA3C tubulin, alpha 3c
UBAC1 UBA domain containing 1
UBQLN4 ubiquilin 4
UNC93B1 unc-93 homolog B1 (C. elegans)
ZNF571 zinc finger protein 571