nomifensine-1378 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the nomifensine-1378 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARF3 ADP-ribosylation factor 3
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB2 arrestin, beta 2
ASMTL acetylserotonin O-methyltransferase-like
ATM ATM serine/threonine kinase
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL2 B-cell CLL/lymphoma 2
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
C2CD2L C2CD2-like
CCL4 chemokine (C-C motif) ligand 4
CCNG2 cyclin G2
CD37 CD37 molecule
CD44 CD44 molecule (Indian blood group)
CHEK1 checkpoint kinase 1
CUL4B cullin 4B
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DSCR3 Down syndrome critical region 3
EDC3 enhancer of mRNA decapping 3
ELMO2 engulfment and cell motility 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENG endoglin
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FN1 fibronectin 1
FPR2 formyl peptide receptor 2
FSCN1 fascin actin-bundling protein 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
H2BFS H2B histone family, member S (pseudogene)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H4C histone cluster 1, H4c
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HUS1 HUS1 checkpoint homolog (S. pombe)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JRK Jrk homolog (mouse)
KLF13 Kruppel-like factor 13
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1 mitogen-activated protein kinase 1
MED1 mediator complex subunit 1
MED13L mediator complex subunit 13-like
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MUTYH mutY homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NFE2L3 nuclear factor, erythroid 2-like 3
NFX1 nuclear transcription factor, X-box binding 1
NOAZFP nucleolar atypical zinc finger
NPFFR1 neuropeptide FF receptor 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR4A2 nuclear receptor subfamily 4, group A, member 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCSK7 proprotein convertase subtilisin/kexin type 7
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
POTEKP POTE ankyrin domain family, member K, pseudogene
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB4B RAB4B, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RASIP1 Ras interacting protein 1
RBM34 RNA binding motif protein 34
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAMP1 secretory carrier membrane protein 1
SEC31B SEC31 homolog B (S. cerevisiae)
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SETD2 SET domain containing 2
SETD8 SET domain containing (lysine methyltransferase) 8
SLC25A40 solute carrier family 25, member 40
SLC25A46 solute carrier family 25, member 46
SOCS5 suppressor of cytokine signaling 5
SSH3 slingshot protein phosphatase 3
STK19 serine/threonine kinase 19
STXBP3 syntaxin binding protein 3
SYNGR1 synaptogyrin 1
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TELO2 telomere maintenance 2
TMED7 transmembrane emp24 protein transport domain containing 7
TPT1 tumor protein, translationally-controlled 1
TRABD TraB domain containing
TSSC4 tumor suppressing subtransferable candidate 4
VEGFA vascular endothelial growth factor A
WDR48 WD repeat domain 48
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZFAND6 zinc finger, AN1-type domain 6
ZNF443 zinc finger protein 443
ZNF85 zinc finger protein 85

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACOT8 acyl-CoA thioesterase 8
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ACVR2A activin A receptor, type IIA
ADAT1 adenosine deaminase, tRNA-specific 1
APOC4 apolipoprotein C-IV
ARMC7 armadillo repeat containing 7
ASB13 ankyrin repeat and SOCS box containing 13
ATAD2B ATPase family, AAA domain containing 2B
ATAT1 alpha tubulin acetyltransferase 1
ATG2A autophagy related 2A
ATG9A autophagy related 9A
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AXIN1 axin 1
CCDC176 coiled-coil domain containing 176
CD248 CD248 molecule, endosialin
CD82 CD82 molecule
CLDN11 claudin 11
COPS7B COP9 signalosome subunit 7B
CTSG cathepsin G
CTSL cathepsin L
DCAF10 DDB1 and CUL4 associated factor 10
DDIT3 DNA-damage-inducible transcript 3
DOK2 docking protein 2, 56kDa
E4F1 E4F transcription factor 1
EPX eosinophil peroxidase
EVL Enah/Vasp-like
FBXW12 F-box and WD repeat domain containing 12
FGF4 fibroblast growth factor 4
FHOD1 formin homology 2 domain containing 1
FKBP2 FK506 binding protein 2, 13kDa
FPGS folylpolyglutamate synthase
GAB2 GRB2-associated binding protein 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GCA grancalcin, EF-hand calcium binding protein
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPR27 G protein-coupled receptor 27
GSTA4 glutathione S-transferase alpha 4
GUSBP3 glucuronidase, beta pseudogene 3
IDO1 indoleamine 2,3-dioxygenase 1
IL4R interleukin 4 receptor
INF2 inverted formin, FH2 and WH2 domain containing
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0556 KIAA0556
KIAA0894 KIAA0894 protein
KIFC1 kinesin family member C1
KLHDC4 kelch domain containing 4
KRT38 keratin 38, type I
LHFPL2 lipoma HMGIC fusion partner-like 2
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LRRC37A3 leucine rich repeat containing 37, member A3
MAGOHB mago-nashi homolog B (Drosophila)
METRN meteorin, glial cell differentiation regulator
MGLL monoglyceride lipase
MMP2 matrix metallopeptidase 2
MTERF4 mitochondrial transcription termination factor 4
NME6 NME/NM23 nucleoside diphosphate kinase 6
NXPH3 neurexophilin 3
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PADI1 peptidyl arginine deiminase, type I
PAK1IP1 PAK1 interacting protein 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PMM2 phosphomannomutase 2
PODNL1 podocan-like 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RBMS3 RNA binding motif, single stranded interacting protein 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRAGA Ras-related GTP binding A
SCAMP5 secretory carrier membrane protein 5
SCN1B sodium channel, voltage gated, type I beta subunit
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLN sarcolipin
SNTA1 syntrophin, alpha 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TESK2 testis-specific kinase 2
TEX40 testis expressed 40
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TMPRSS6 transmembrane protease, serine 6
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSC22D1 TSC22 domain family, member 1
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBXN6 UBX domain protein 6
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WDR19 WD repeat domain 19
ZBED1 zinc finger, BED-type containing 1
ZNF140 zinc finger protein 140
ZNF160 zinc finger protein 160
ZNF264 zinc finger protein 264
ZNF408 zinc finger protein 408
ZNF652 zinc finger protein 652
ZNF669 zinc finger protein 669