noonan syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_3490)
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Genes

74 genes co-occuring with the disease noonan syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PTPN11 protein tyrosine phosphatase, non-receptor type 11 3.1165
SOS1 son of sevenless homolog 1 (Drosophila) 2.56665
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.44238
HRAS Harvey rat sarcoma viral oncogene homolog 1.78308
MAP2K2 mitogen-activated protein kinase kinase 2 1.69996
NF1 neurofibromin 1 1.63455
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.61441
MAP2K1 mitogen-activated protein kinase kinase 1 1.61039
KRAS Kirsten rat sarcoma viral oncogene homolog 1.56889
PTPN3 protein tyrosine phosphatase, non-receptor type 3 1.41534
MPZL1 myelin protein zero-like 1 1.28173
RPL6 ribosomal protein L6 1.17808
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.09923
GAB1 GRB2-associated binding protein 1 1.08118
SPRED1 sprouty-related, EVH1 domain containing 1 1.07782
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.00499
CSH2 chorionic somatomammotropin hormone 2 0.982215
FMO2 flavin containing monooxygenase 2 (non-functional) 0.97002
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.961634
F11 coagulation factor XI 0.933727
RIT1 Ras-like without CAAX 1 0.927105
SHOX short stature homeobox 0.921323
SH3BP2 SH3-domain binding protein 2 0.889258
RASA2 RAS p21 protein activator 2 0.860999
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.813052
SOS2 son of sevenless homolog 2 (Drosophila) 0.766351
CPLX3 complexin 3 0.743954
IGF1 insulin-like growth factor 1 (somatomedin C) 0.733406
MED13 mediator complex subunit 13 0.720058
MED13L mediator complex subunit 13-like 0.713198
IGFBP3 insulin-like growth factor binding protein 3 0.682294
RASIP1 Ras interacting protein 1 0.658422
KAT6B K(lysine) acetyltransferase 6B 0.638676
STAT5B signal transducer and activator of transcription 5B 0.631205
ARID3B AT rich interactive domain 3B (BRIGHT-like) 0.628457
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.590558
PTS 6-pyruvoyltetrahydropterin synthase 0.568775
FGF13 fibroblast growth factor 13 0.565666
DTX1 deltex 1, E3 ubiquitin ligase 0.554015
SCRIB scribbled planar cell polarity protein 0.545481
GRB2 growth factor receptor-bound protein 2 0.539667
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.530768
MCF2 MCF.2 cell line derived transforming sequence 0.519575
IGFALS insulin-like growth factor binding protein, acid labile subunit 0.516879
LIG3 ligase III, DNA, ATP-dependent 0.512648
GRIP1 glutamate receptor interacting protein 1 0.498085
EPS8 epidermal growth factor receptor pathway substrate 8 0.495793
NDE1 nudE neurodevelopment protein 1 0.462016
PROX1 prospero homeobox 1 0.459751
FGF17 fibroblast growth factor 17 0.455601
TBX20 T-box 20 0.448817
GHR growth hormone receptor 0.434148
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.418768
ZHX2 zinc fingers and homeoboxes 2 0.41727
SIN3A SIN3 transcription regulator family member A 0.415024
STRA6 stimulated by retinoic acid 6 0.409414
RRAS related RAS viral (r-ras) oncogene homolog 0.400453
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.359289
PTPRD protein tyrosine phosphatase, receptor type, D 0.353027
MYBPC2 myosin binding protein C, fast type 0.339806
SOX18 SRY (sex determining region Y)-box 18 0.309566
PTPRJ protein tyrosine phosphatase, receptor type, J 0.297291
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.289744
FHL1 four and a half LIM domains 1 0.237009
FRS2 fibroblast growth factor receptor substrate 2 0.236312
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.22145
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.220766
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.211597
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.205254
SYNE1 spectrin repeat containing, nuclear envelope 1 0.195183
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.185313
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.162306
INSL3 insulin-like 3 (Leydig cell) 0.162109
GAB2 GRB2-associated binding protein 2 0.160574