nordihydroguaiaretic acid-4447 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the nordihydroguaiaretic acid-4447 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACO2 aconitase 2, mitochondrial
ACRV1 acrosomal vesicle protein 1
AGBL2 ATP/GTP binding protein-like 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANK2 ankyrin 2, neuronal
ANO2 anoctamin 2, calcium activated chloride channel
APOF apolipoprotein F
C6ORF10 chromosome 6 open reading frame 10
CA12 carbonic anhydrase XII
CACFD1 calcium channel flower domain containing 1
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALCR calcitonin receptor
CCDC132 coiled-coil domain containing 132
CCR2 chemokine (C-C motif) receptor 2
CD22 CD22 molecule
CDC25C cell division cycle 25C
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CH25H cholesterol 25-hydroxylase
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC5 chloride intracellular channel 5
COL8A2 collagen, type VIII, alpha 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DOK2 docking protein 2, 56kDa
FGF1 fibroblast growth factor 1 (acidic)
FGF16 fibroblast growth factor 16
FYB FYN binding protein
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GEMIN7 gem (nuclear organelle) associated protein 7
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GUCA2A guanylate cyclase activator 2A (guanylin)
GZMM granzyme M (lymphocyte met-ase 1)
HAP1 huntingtin-associated protein 1
HEG1 heart development protein with EGF-like domains 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLRD1 killer cell lectin-like receptor subfamily D, member 1
LMO1 LIM domain only 1 (rhombotin 1)
LY6G6E lymphocyte antigen 6 complex, locus G6E (pseudogene)
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAP7D3 MAP7 domain containing 3
MARK1 MAP/microtubule affinity-regulating kinase 1
MBD2 methyl-CpG binding domain protein 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT3 metallothionein 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC8 mucin 8
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NEK1 NIMA-related kinase 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NPTX1 neuronal pentraxin I
NRF1 nuclear respiratory factor 1
NRXN3 neurexin 3
OSGIN2 oxidative stress induced growth inhibitor family member 2
OVOL1 ovo-like zinc finger 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDZD3 PDZ domain containing 3
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PKNOX2 PBX/knotted 1 homeobox 2
PLCG1 phospholipase C, gamma 1
PLIN2 perilipin 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDM1 PR domain containing 1, with ZNF domain
PROM1 prominin 1
PSG3 pregnancy specific beta-1-glycoprotein 3
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB33A RAB33A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RUNX1 runt-related transcription factor 1
SCGB1D1 secretoglobin, family 1D, member 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SFRP1 secreted frizzled-related protein 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SP110 SP110 nuclear body protein
ST7L suppression of tumorigenicity 7 like
STC1 stanniocalcin 1
SYCE1L synaptonemal complex central element protein 1-like
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TAPT1 transmembrane anterior posterior transformation 1
TBC1D2B TBC1 domain family, member 2B
TBKBP1 TBK1 binding protein 1
TCN2 transcobalamin II
TFF3 trefoil factor 3 (intestinal)
TMPRSS2 transmembrane protease, serine 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRAPPC9 trafficking protein particle complex 9
TRIM49 tripartite motif containing 49
TRIO trio Rho guanine nucleotide exchange factor
TRO trophinin
UCN urocortin
WAS Wiskott-Aldrich syndrome
ZNF334 zinc finger protein 334

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADGRB2 adhesion G protein-coupled receptor B2
AKIP1 A kinase (PRKA) interacting protein 1
ANKH ANKH inorganic pyrophosphate transport regulator
AOC2 amine oxidase, copper containing 2 (retina-specific)
AURKC aurora kinase C
BCAS3 breast carcinoma amplified sequence 3
C14ORF93 chromosome 14 open reading frame 93
C1QTNF1 C1q and tumor necrosis factor related protein 1
C1QTNF3 C1q and tumor necrosis factor related protein 3
CBX8 chromobox homolog 8
CCDC106 coiled-coil domain containing 106
CCDC85C coiled-coil domain containing 85C
CENPQ centromere protein Q
CFAP69 cilia and flagella associated protein 69
COBL cordon-bleu WH2 repeat protein
DBF4B DBF4 zinc finger B
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND2D DENN/MADD domain containing 2D
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DTX2 deltex 2, E3 ubiquitin ligase
EN1 engrailed homeobox 1
EPN3 epsin 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM188A family with sequence similarity 188, member A
FBRS fibrosin
FRMD1 FERM domain containing 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GLB1L2 galactosidase, beta 1-like 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HDAC11 histone deacetylase 11
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AM histone cluster 1, H2am
HIST1H2BC histone cluster 1, H2bc
HIST1H3B histone cluster 1, H3b
HIST1H3C histone cluster 1, H3c
HIST1H3G histone cluster 1, H3g
HIST1H4C histone cluster 1, H4c
HIST1H4E histone cluster 1, H4e
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA4 homeobox A4
HOXC13 homeobox C13
IL12A interleukin 12A
IL12RB1 interleukin 12 receptor, beta 1
IL4R interleukin 4 receptor
INCENP inner centromere protein antigens 135/155kDa
IPO8 importin 8
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
LINC00597 long intergenic non-protein coding RNA 597
LINS lines homolog (Drosophila)
LIPG lipase, endothelial
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MGP matrix Gla protein
MRPL44 mitochondrial ribosomal protein L44
MTA2 metastasis associated 1 family, member 2
MTMR6 myotubularin related protein 6
MX1 MX dynamin-like GTPase 1
MYH15 myosin, heavy chain 15
NBEAL2 neurobeachin-like 2
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NPFFR1 neuropeptide FF receptor 1
OLFML2B olfactomedin-like 2B
PCDHGB5 protocadherin gamma subfamily B, 5
PID1 phosphotyrosine interaction domain containing 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POMT1 protein-O-mannosyltransferase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PQLC2 PQ loop repeat containing 2
PRKG2 protein kinase, cGMP-dependent, type II
RAP1GAP2 RAP1 GTPase activating protein 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
SCARA3 scavenger receptor class A, member 3
SCGB2A2 secretoglobin, family 2A, member 2
SCN9A sodium channel, voltage gated, type IX alpha subunit
SIRT2 sirtuin 2
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC22A14 solute carrier family 22, member 14
SLC25A40 solute carrier family 25, member 40
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPEG SPEG complex locus
TESK1 testis-specific kinase 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM19 transmembrane protein 19
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TPRA1 transmembrane protein, adipocyte asscociated 1
TUBA3C tubulin, alpha 3c
ZNF286A zinc finger protein 286A
ZNF408 zinc finger protein 408
ZNF446 zinc finger protein 446
ZNF623 zinc finger protein 623
ZW10 zw10 kinetochore protein