notch3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description notch 3|This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4854)
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Genes

38 genes co-occuring with the biological term notch3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOD apolipoprotein D
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CCAR1 cell division cycle and apoptosis regulator 1
CCND1 cyclin D1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CTCFL CCCTC-binding factor (zinc finger protein)-like
DLL1 delta-like 1 (Drosophila)
DLL4 delta-like 4 (Drosophila)
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
HES1 hes family bHLH transcription factor 1
HES5 hes family bHLH transcription factor 5
HES6 hes family bHLH transcription factor 6
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
IL6 interleukin 6
JAG1 jagged 1
JAG2 jagged 2
MAPK14 mitogen-activated protein kinase 14
MIR1-1 microRNA 1-1
MIR150 microRNA 150
MIR206 microRNA 206
MSI1 musashi RNA-binding protein 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NOTCH4 notch 4
PAWR PRKC, apoptosis, WT1, regulator
PBX1 pre-B-cell leukemia homeobox 1
PTCRA pre T-cell antigen receptor alpha
RGS5 regulator of G-protein signaling 5
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
STRAP serine/threonine kinase receptor associated protein
THAP1 THAP domain containing, apoptosis associated protein 1