novobiocin-2990 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the novobiocin-2990 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
APC2 adenomatosis polyposis coli 2
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ART4 ADP-ribosyltransferase 4 (Dombrock blood group)
ARTN artemin
ATP9A ATPase, class II, type 9A
BCL2L1 BCL2-like 1
BEND5 BEN domain containing 5
BMP7 bone morphogenetic protein 7
BPI bactericidal/permeability-increasing protein
CASZ1 castor zinc finger 1
CCDC181 coiled-coil domain containing 181
CCDC87 coiled-coil domain containing 87
CCNK cyclin K
CD163 CD163 molecule
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CEP112 centrosomal protein 112kDa
CFAP74 cilia and flagella associated protein 74
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPN2 carboxypeptidase N, polypeptide 2
CRP C-reactive protein, pentraxin-related
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DHODH dihydroorotate dehydrogenase (quinone)
DOK3 docking protein 3
EDA ectodysplasin A
EGLN3 egl-9 family hypoxia-inducible factor 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMC3 ER membrane protein complex subunit 3
EPO erythropoietin
GLRX3 glutaredoxin 3
GMPR guanosine monophosphate reductase
HIPK3 homeodomain interacting protein kinase 3
HLA-F major histocompatibility complex, class I, F
HOXB1 homeobox B1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IL36RN interleukin 36 receptor antagonist
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KHK ketohexokinase (fructokinase)
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LARP6 La ribonucleoprotein domain family, member 6
LIMD2 LIM domain containing 2
LIMS2 LIM and senescent cell antigen-like domains 2
LRRN2 leucine rich repeat neuronal 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MARC1 mitochondrial amidoxime reducing component 1
MED14 mediator complex subunit 14
MFAP3L microfibrillar-associated protein 3-like
MNMIP1 manchette microtubule inner protein 1
MUC1 mucin 1, cell surface associated
MYBPC2 myosin binding protein C, fast type
MYL10 myosin, light chain 10, regulatory
MYOD1 myogenic differentiation 1
MYOZ3 myozenin 3
ONECUT2 one cut homeobox 2
OPCML opioid binding protein/cell adhesion molecule-like
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
PACRG PARK2 co-regulated
PCDHGA8 protocadherin gamma subfamily A, 8
PICK1 protein interacting with PRKCA 1
PNPLA4 patatin-like phospholipase domain containing 4
PSG4 pregnancy specific beta-1-glycoprotein 4
PTHLH parathyroid hormone-like hormone
PVR poliovirus receptor
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF122 ring finger protein 122
RNGTT RNA guanylyltransferase and 5'-phosphatase
ROM1 retinal outer segment membrane protein 1
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIM2 single-minded family bHLH transcription factor 2
SIX2 SIX homeobox 2
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SOX21 SRY (sex determining region Y)-box 21
SPRR2B small proline-rich protein 2B
TDRD1 tudor domain containing 1
TEX13A testis expressed 13A
TMEM51 transmembrane protein 51
TMEM53 transmembrane protein 53
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TPM3 tropomyosin 3
VAMP5 vesicle-associated membrane protein 5
VCX2 variable charge, X-linked 2
VPS9D1 VPS9 domain containing 1
WDR1 WD repeat domain 1
WDR59 WD repeat domain 59
ZBTB17 zinc finger and BTB domain containing 17
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC4 zinc finger, CCHC domain containing 4
ZNF154 zinc finger protein 154

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADGB androglobin
ADGRE2 adhesion G protein-coupled receptor E2
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AKTIP AKT interacting protein
ANXA2P3 annexin A2 pseudogene 3
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
BNC2 basonuclin 2
BTBD18 BTB (POZ) domain containing 18
BTF3P11 basic transcription factor 3 pseudogene 11
C3ORF18 chromosome 3 open reading frame 18
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CCDC85C coiled-coil domain containing 85C
CD82 CD82 molecule
CDHR2 cadherin-related family member 2
CDKL3 cyclin-dependent kinase-like 3
CEP72 centrosomal protein 72kDa
CHML choroideremia-like (Rab escort protein 2)
CST1 cystatin SN
CTSD cathepsin D
CXCL2 chemokine (C-X-C motif) ligand 2
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DPYS dihydropyrimidinase
EBF2 early B-cell factor 2
FHIT fragile histidine triad
FHL3 four and a half LIM domains 3
FKBP14 FK506 binding protein 14, 22 kDa
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GAREM GRB2 associated, regulator of MAPK1
GIPC1 GIPC PDZ domain containing family, member 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
HDAC7 histone deacetylase 7
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST1H3H histone cluster 1, H3h
HOXC8 homeobox C8
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFT54 intraflagellar transport 54
IL2 interleukin 2
JAM3 junctional adhesion molecule 3
JPH3 junctophilin 3
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0753 KIAA0753
KIAA1024 KIAA1024
KIAA1107 KIAA1107
KPTN kaptin (actin binding protein)
LPPR1 lipid phosphate phosphatase-related protein type 1
LTA lymphotoxin alpha
LTBP2 latent transforming growth factor beta binding protein 2
MAGEH1 melanoma antigen family H1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP6D1 MAP6 domain containing 1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MOCS3 molybdenum cofactor synthesis 3
MYH4 myosin, heavy chain 4, skeletal muscle
NCKAP1L NCK-associated protein 1-like
NINJ2 ninjurin 2
NMUR1 neuromedin U receptor 1
NNAT neuronatin
PCBP4 poly(rC) binding protein 4
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKD2L2 polycystic kidney disease 2-like 2
PLA2G3 phospholipase A2, group III
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLS1 plastin 1
PMP22 peripheral myelin protein 22
POTEKP POTE ankyrin domain family, member K, pseudogene
PRSS53 protease, serine, 53
RAB17 RAB17, member RAS oncogene family
RAB40A RAB40A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RPAP1 RNA polymerase II associated protein 1
SCRT1 scratch family zinc finger 1
SETD1A SET domain containing 1A
SLC16A6 solute carrier family 16, member 6
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SRPX sushi-repeat containing protein, X-linked
STAT5A signal transducer and activator of transcription 5A
TAS2R10 taste receptor, type 2, member 10
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCHH trichohyalin
TFDP3 transcription factor Dp family, member 3
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM180 transmembrane protein 180
TMEM184C transmembrane protein 184C
TNNT1 troponin T type 1 (skeletal, slow)
UNC13A unc-13 homolog A (C. elegans)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
XAB2 XPA binding protein 2
ZC3H12A zinc finger CCCH-type containing 12A
ZNF155 zinc finger protein 155
ZNF81 zinc finger protein 81