nr1h2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description nuclear receptor subfamily 1, group H, member 2|The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010] (NCBI Entrez Gene Database, 7376)
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Genes

14 genes co-occuring with the biological term nr1h2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGER advanced glycosylation end product-specific receptor
ECE1 endothelin converting enzyme 1
ECE2 endothelin converting enzyme 2
LRP1 low density lipoprotein receptor-related protein 1
MMEL1 membrane metallo-endopeptidase-like 1
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
PLAT plasminogen activator, tissue
PLG plasminogen
RORA RAR-related orphan receptor A
RORC RAR-related orphan receptor C
TTR transthyretin