nr1i2 Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	nuclear receptor subfamily 1, group I, member 2\|This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8856)
Similar Terms
Downloads & Tools

Genes

15 genes co-occuring with the biological term nr1i2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6
CYP3A	cytochrome P450, family 3, subfamily A
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4
ESR1	estrogen receptor 1
ETV6	ets variant 6
GATA1	GATA binding protein 1 (globin transcription factor 1)
MIR34A	microRNA 34a
NR1I2	nuclear receptor subfamily 1, group I, member 2
NR1I3	nuclear receptor subfamily 1, group I, member 3
PIAS3	protein inhibitor of activated STAT, 3
PPARA	peroxisome proliferator-activated receptor alpha
RXRA	retinoid X receptor, alpha