nuclear lamina Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane. (Gene Ontology, GO_0005652)
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Genes

120 proteins co-occuring with the nuclear lamina cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
LMNA lamin A/C 3.04714
LMNB1 lamin B1 2.26202
EMD emerin 2.23297
LMNB2 lamin B2 1.96497
ZMPSTE24 zinc metallopeptidase STE24 1.85799
LBR lamin B receptor 1.71001
BANF1 barrier to autointegration factor 1 1.44629
ZNF233 zinc finger protein 233 1.24131
ZNF239 zinc finger protein 239 1.24131
CDK1 cyclin-dependent kinase 1 1.07308
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 1.02331
LEMD3 LEM domain containing 3 0.993672
SUN1 Sad1 and UNC84 domain containing 1 0.974682
PRR14 proline rich 14 0.955917
NUP153 nucleoporin 153kDa 0.944007
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 0.931716
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.912045
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.876409
PPAPDC3 phosphatidic acid phosphatase type 2 domain containing 3 0.808441
ANKLE1 ankyrin repeat and LEM domain containing 1 0.791022
RCE1 Ras converting CAAX endopeptidase 1 0.741416
NUMA1 nuclear mitotic apparatus protein 1 0.689013
NUP155 nucleoporin 155kDa 0.598538
TPR translocated promoter region, nuclear basket protein 0.574244
SUN5 Sad1 and UNC84 domain containing 5 0.531668
FBXO17 F-box protein 17 0.525522
SARS seryl-tRNA synthetase 0.513677
DES desmin 0.499447
MARS methionyl-tRNA synthetase 0.492561
SREBF1 sterol regulatory element binding transcription factor 1 0.489731
NUP93 nucleoporin 93kDa 0.483676
GRHL3 grainyhead-like 3 (Drosophila) 0.478843
HDAC3 histone deacetylase 3 0.476429
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 0.475223
CTCF CCCTC-binding factor (zinc finger protein) 0.461599
NUP205 nucleoporin 205kDa 0.440124
MYOD1 myogenic differentiation 1 0.437356
SYNE1 spectrin repeat containing, nuclear envelope 1 0.434196
PUS3 pseudouridylate synthase 3 0.433801
TBATA thymus, brain and testes associated 0.432224
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 0.427104
DNASE2B deoxyribonuclease II beta 0.423567
PODN podocan 0.420428
ZNF350 zinc finger protein 350 0.416511
CKAP2 cytoskeleton associated protein 2 0.41221
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.407919
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.400527
GFAP glial fibrillary acidic protein 0.400139
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.388523
CCNB1 cyclin B1 0.385436
YARS tyrosyl-tRNA synthetase 0.380429
TM7SF2 transmembrane 7 superfamily member 2 0.371599
HRAS Harvey rat sarcoma viral oncogene homolog 0.370833
TMEM43 transmembrane protein 43 0.365477
FBXO8 F-box protein 8 0.358609
PPARG peroxisome proliferator-activated receptor gamma 0.358228
CCND3 cyclin D3 0.358228
DPF2 D4, zinc and double PHD fingers family 2 0.352522
RNF123 ring finger protein 123 0.352142
HIST1H2AM histone cluster 1, H2am 0.351762
H2AFJ H2A histone family, member J 0.351762
HIST1H2AH histone cluster 1, H2ah 0.351762
HIST1H2AJ histone cluster 1, H2aj 0.351762
HIST1H2AD histone cluster 1, H2ad 0.351762
HIST1H2AG histone cluster 1, H2ag 0.350622
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.350243
H2AFY2 H2A histone family, member Y2 0.348725
HIST1H2AE histone cluster 1, H2ae 0.348346
HIST1H2AB histone cluster 1, H2ab 0.348346
H2AFV H2A histone family, member V 0.347967
MBNL2 muscleblind-like splicing regulator 2 0.34645
H2AFB1 H2A histone family, member B1 0.344935
H2AFB2 H2A histone family, member B2 0.341529
H2AFY H2A histone family, member Y 0.338128
NCAPD3 non-SMC condensin II complex, subunit D3 0.325702
MAD2L1P1 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene 1 0.312597
NAP1L1 nucleosome assembly protein 1-like 1 0.311105
WRN Werner syndrome, RecQ helicase-like 0.296972
DUSP4 dual specificity phosphatase 4 0.293267
EP300 E1A binding protein p300 0.291417
NUP107 nucleoporin 107kDa 0.285507
NUP35 nucleoporin 35kDa 0.277774
TCHH trichohyalin 0.272267
ATM ATM serine/threonine kinase 0.269335
CXXC1 CXXC finger protein 1 0.266774
LMO7 LIM domain 7 0.266408
IGF2 insulin-like growth factor 2 0.265677
PRDM16 PR domain containing 16 0.259837
SIN3B SIN3 transcription regulator family member B 0.252564
TRIM27 tripartite motif containing 27 0.251114
MECP2 methyl CpG binding protein 2 0.229176
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.228108
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.224913
DHCR7 7-dehydrocholesterol reductase 0.223143
PCNA proliferating cell nuclear antigen 0.222436
PSIP1 PC4 and SFRS1 interacting protein 1 0.217861
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.217861
MYOG myogenin (myogenic factor 4) 0.205059
PAX7 paired box 7 0.202684
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.197662
TWIST2 twist family bHLH transcription factor 2 0.194698
TMPO thymopoietin 0.191456
FKBP4 FK506 binding protein 4, 59kDa 0.190495
RANBP2 RAN binding protein 2 0.187333
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.183631
DUOXA1 dual oxidase maturation factor 1 0.182422
H3F3B H3 histone, family 3B (H3.3B) 0.18093
H3F3A H3 histone, family 3A 0.18093
PARP1 poly (ADP-ribose) polymerase 1 0.179167
DHCR24 24-dehydrocholesterol reductase 0.178011
POU2F1 POU class 2 homeobox 1 0.17687
H2AFX H2A histone family, member X 0.176587
CIDEC cell death-inducing DFFA-like effector c 0.17141
AHCTF1 AT hook containing transcription factor 1 0.166643
FKRP fukutin related protein 0.166643
A2M alpha-2-macroglobulin 0.165932
APOPT1 apoptogenic 1, mitochondrial 0.162117
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.161068
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.160456
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.158882