nuclear speck Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. (Gene Ontology, GO_0016607)
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Genes

125 proteins localized to the nuclear speck cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CIR1 corepressor interacting with RBPJ, 1 0.663342
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.663342
WTAP Wilms tumor 1 associated protein 0.663342
RNPS1 RNA binding protein S1, serine-rich domain 0.663342
FTO fat mass and obesity associated 0.663342
SON SON DNA binding protein 0.663342
THAP7 THAP domain containing 7 0.663342
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.663342
ATXN2L ataxin 2-like 0.663342
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.663342
PRPF31 pre-mRNA processing factor 31 0.663342
ELL elongation factor RNA polymerase II 0.663342
WT1 Wilms tumor 1 0.663342
OGG1 8-oxoguanine DNA glycosylase 0.663342
DGKQ diacylglycerol kinase, theta 110kDa 0.663342
RBM39 RNA binding motif protein 39 0.663342
PHF5A PHD finger protein 5A 0.663342
CDK12 cyclin-dependent kinase 12 0.663342
CDK13 cyclin-dependent kinase 13 0.663342
CBY1 chibby homolog 1 (Drosophila) 0.663342
PPP1R8 protein phosphatase 1, regulatory subunit 8 0.663342
RBM4 RNA binding motif protein 4 0.663342
ALYREF Aly/REF export factor 0.663342
ACIN1 apoptotic chromatin condensation inducer 1 0.663342
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.663342
RBM11 RNA binding motif protein 11 0.663342
SRSF6 serine/arginine-rich splicing factor 6 0.663342
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase 0.663342
SART3 squamous cell carcinoma antigen recognized by T cells 3 0.663342
ALKBH5 AlkB family member 5, RNA demethylase 0.663342
THOC1 THO complex 1 0.663342
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.663342
FYTTD1 forty-two-three domain containing 1 0.663342
METTL3 methyltransferase like 3 0.663342
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.663342
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.663342
CWC22 CWC22 spliceosome-associated protein 0.663342
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 0.663342
CHTOP chromatin target of PRMT1 0.663342
SF3A3 splicing factor 3a, subunit 3, 60kDa 0.663342
SRSF1 serine/arginine-rich splicing factor 1 0.663342
SRSF2 serine/arginine-rich splicing factor 2 0.663342
SRY sex determining region Y 0.663342
SAP18 Sin3A-associated protein, 18kDa 0.663342
AKAP17A A kinase (PRKA) anchor protein 17A 0.663342
U2AF2 U2 small nuclear RNA auxiliary factor 2 0.663342
EIF4A3 eukaryotic translation initiation factor 4A3 0.663342
MBD1 methyl-CpG binding domain protein 1 0.663342
ZBTB16 zinc finger and BTB domain containing 16 0.663342
TRIM69 tripartite motif containing 69 0.663342
SUMO1 small ubiquitin-like modifier 1 0.663342
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.663342
EAF1 ELL associated factor 1 0.663342
ZC3H14 zinc finger CCCH-type containing 14 0.663342
PLRG1 pleiotropic regulator 1 0.663342
PNN pinin, desmosome associated protein 0.663342
MECOM MDS1 and EVI1 complex locus 0.663342
CDC5L cell division cycle 5-like 0.663342
SRRM1 serine/arginine repetitive matrix 1 0.663342
SRRM2 serine/arginine repetitive matrix 2 0.663342
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.663342
NEK6 NIMA-related kinase 6 0.663342
PYHIN1 pyrin and HIN domain family, member 1 0.663342
HSPA1B heat shock 70kDa protein 1B 0.663342
SPOP speckle-type POZ protein 0.663342
HSPA1A heat shock 70kDa protein 1A 0.663342
AFF2 AF4/FMR2 family, member 2 0.663342
CRNKL1 crooked neck pre-mRNA splicing factor 1 0.663342
RBM27 RNA binding motif protein 27 0.663342
RBM25 RNA binding motif protein 25 0.663342
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 0.663342
WBP4 WW domain binding protein 4 0.663342
CSNK1A1 casein kinase 1, alpha 1 0.663342
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.663342
PSKH1 protein serine kinase H1 0.663342
CBX4 chromobox homolog 4 0.663342
EEF1G eukaryotic translation elongation factor 1 gamma 0.663342
SARNP SAP domain containing ribonucleoprotein 0.663342
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 0.663342
PSPC1 paraspeckle component 1 0.663342
IFI16 interferon, gamma-inducible protein 16 0.663342
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.663342
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.663342
NSRP1 nuclear speckle splicing regulatory protein 1 0.663342
CASC3 cancer susceptibility candidate 3 0.663342
NONO non-POU domain containing, octamer-binding 0.663342
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 0.663342
PIAS2 protein inhibitor of activated STAT, 2 0.663342
NXF1 nuclear RNA export factor 1 0.663342
TRIM22 tripartite motif containing 22 0.663342
PRPF3 pre-mRNA processing factor 3 0.663342
PRPF6 pre-mRNA processing factor 6 0.663342
CLK2 CDC-like kinase 2 0.663342
CLK3 CDC-like kinase 3 0.663342
SMNDC1 survival motor neuron domain containing 1 0.663342
SPRTN SprT-like N-terminal domain 0.237908
CXXC1 CXXC finger protein 1 0.237908
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.237908
TENM1 teneurin transmembrane protein 1 0.237908
EP400 E1A binding protein p400 0.237908
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.237908
BASP1 brain abundant, membrane attached signal protein 1 0.237908
PRPF19 pre-mRNA processing factor 19 0.237908
RSRC1 arginine/serine-rich coiled-coil 1 0.237908
SRSF5 serine/arginine-rich splicing factor 5 0.237908
PPIH peptidylprolyl isomerase H (cyclophilin H) 0.237908
MEF2C myocyte enhancer factor 2C 0.237908
SRSF3 serine/arginine-rich splicing factor 3 0.237908
PQBP1 polyglutamine binding protein 1 0.237908
TFIP11 tuftelin interacting protein 11 0.237908
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 0.237908
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.237908
GLIS2 GLIS family zinc finger 2 0.237908
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 0.237908
ZCCHC12 zinc finger, CCHC domain containing 12 0.098109
ZNF830 zinc finger protein 830 0.03318
CRTC1 CREB regulated transcription coactivator 1 0.03318
CCNL1 cyclin L1 0.03318
GLI3 GLI family zinc finger 3 0.03318
MAML1 mastermind-like 1 (Drosophila) 0.03318
MAML3 mastermind-like 3 (Drosophila) 0.03318
WBP11 WW domain binding protein 11 0.03318
MAML2 mastermind-like 2 (Drosophila) 0.03318
GLI2 GLI family zinc finger 2 0.03318
HIPK1 homeodomain interacting protein kinase 1 0.03318