nuclease activity Gene Set

Dataset GO Molecular Function Annotations 2023
Category structural or functional annotations
Type biological process
Description Catalysis of the hydrolysis of ester linkages within nucleic acids. (Gene Ontology, GO_0004518)
External Link http://amigo.geneontology.org/amigo/term/GO:0004518
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Genes

59 genes performing the nuclease activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

Symbol Name
AEN apoptosis enhancing nuclease
ANG angiogenin, ribonuclease, RNase A family, 5
ANKLE1 ankyrin repeat and LEM domain containing 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
DCLRE1C DNA cross-link repair 1C
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DIS3L2 DIS3 like 3'-5' exoribonuclease 2
DNA2 DNA replication helicase/nuclease 2
DNASE1L3 deoxyribonuclease I-like 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERCC5 excision repair cross-complementation group 5
ERN2 endoplasmic reticulum to nucleus signaling 2
EXO1 exonuclease 1
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FEN1 flap structure-specific endonuclease 1
ISG20 interferon stimulated exonuclease gene 20kDa
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
MAP1S microtubule-associated protein 1S
MRE11 MRE11 homolog, double strand break repair nuclease
MUS81 MUS81 structure-specific endonuclease subunit
N4BP1 NEDD4 binding protein 1
N4BP2 NEDD4 binding protein 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NTHL1 nth endonuclease III-like 1 (E. coli)
OGG1 8-oxoguanine DNA glycosylase
PARN poly(A)-specific ribonuclease
PDE12 phosphodiesterase 12
PLSCR1 phospholipid scramblase 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PNKP polynucleotide kinase 3'-phosphatase
RAG1 recombination activating gene 1
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae)
REXO1L1P REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1, pseudogene
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
REXO5 RNA exonuclease 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE10 ribonuclease, RNase A family, 10 (non-active)
RNASE11 ribonuclease, RNase A family, 11 (non-active)
RNASE12 ribonuclease, RNase A family, 12 (non-active)
RNASE13 ribonuclease, RNase A family, 13 (non-active)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNASE6 ribonuclease, RNase A family, k6
RNASE7 ribonuclease, RNase A family, 7
RNASE8 ribonuclease, RNase A family, 8
RNASEH1 ribonuclease H1
RNASEH2A ribonuclease H2, subunit A
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNASET2 ribonuclease T2
SAMHD1 SAM domain and HD domain 1
SETMAR SET domain and mariner transposase fusion gene
SLFN12 schlafen family member 12
SND1 staphylococcal nuclease and tudor domain containing 1
WRN Werner syndrome, RecQ helicase-like
XRN2 5'-3' exoribonuclease 2
ZC3H12A zinc finger CCCH-type containing 12A