numb Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description numb homolog (Drosophila)|The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8650)
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Genes

28 genes co-occuring with the biological term numb in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AAK1 AP2 associated kinase 1
APP amyloid beta (A4) precursor protein
CHUK conserved helix-loop-helix ubiquitous kinase
CTNND1 catenin (cadherin-associated protein), delta 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DLL1 delta-like 1 (Drosophila)
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
GLI1 GLI family zinc finger 1
IRAK1 interleukin-1 receptor-associated kinase 1
ITCH itchy E3 ubiquitin protein ligase
ITSN2 intersectin 2
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR146A microRNA 146a
NOTCH1 notch 1
NOTCH3 notch 3
NPC1L1 NPC1-like 1
NUMB numb homolog (Drosophila)
PARD3 par-3 family cell polarity regulator
PLK1 polo-like kinase 1
PRKCI protein kinase C, iota
RBX1 ring-box 1, E3 ubiquitin protein ligase
SETD8 SET domain containing (lysine methyltransferase) 8
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase