obese Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An eating-related disorder in which excess body fat has accumulated to such an extent that health may be negatively affected. It is commonly defined as a body mass index (weight divided by height squared) of 30 kg/m2 or higher.|A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). (Experimental Factor Ontology, EFO_0001073)
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Genes

363 genes co-occuring with the biological term obese in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACACA acetyl-CoA carboxylase alpha
ACE angiotensin I converting enzyme
ACP5 acid phosphatase 5, tartrate resistant
ADAM17 ADAM metallopeptidase domain 17
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADIPQTL3 Circulating adiponectin QTL on chromosome 14
ADIRF adipogenesis regulatory factor
ADRA2B adrenoceptor alpha 2B
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGRP agouti related neuropeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMH anti-Mullerian hormone
ANXA6 annexin A6
AOC3 amine oxidase, copper containing 3
APLN apelin
APOA1 apolipoprotein A-I
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
AQP7 aquaporin 7
AQP9 aquaporin 9
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATRN attractin
AVPR1A arginine vasopressin receptor 1A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BGLAP bone gamma-carboxyglutamate (gla) protein
BRCA1 breast cancer 1, early onset
C1QTNF1 C1q and tumor necrosis factor related protein 1
C3 complement component 3
CALCA calcitonin-related polypeptide alpha
CAPN10 calpain 10
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CCKAR cholecystokinin A receptor
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CETP cholesteryl ester transfer protein, plasma
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIT1 chitinase 1 (chitotriosidase)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLOCK clock circadian regulator
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COL18A1 collagen, type XVIII, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CPE carboxypeptidase E
CRP C-reactive protein, pentraxin-related
CRY1 cryptochrome circadian clock 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSK cathepsin K
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CYBA cytochrome b-245, alpha polypeptide
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
EDN1 endothelin 1
ENHO energy homeostasis associated
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAAH fatty acid amide hydrolase
FABP2 fatty acid binding protein 2, intestinal
FABP4 fatty acid binding protein 4, adipocyte
FABP6 fatty acid binding protein 6, ileal
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FAT1 FAT atypical cadherin 1
FFAR4 free fatty acid receptor 4
FGA fibrinogen alpha chain
FGF19 fibroblast growth factor 19
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FNDC5 fibronectin type III domain containing 5
FOXA3 forkhead box A3
FOXO1 forkhead box O1
FSHR follicle stimulating hormone receptor
FST follistatin
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
FTO fat mass and obesity associated
G6PC2 glucose-6-phosphatase, catalytic, 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAL galanin/GMAP prepropeptide
GALR1 galanin receptor 1
GAS6 growth arrest-specific 6
GCG glucagon
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GDF15 growth differentiation factor 15
GGT1 gamma-glutamyltransferase 1
GH1 growth hormone 1
GHRH growth hormone releasing hormone
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GIPR gastric inhibitory polypeptide receptor
GLP1R glucagon-like peptide 1 receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GPS2 G protein pathway suppressor 2
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GPX3 glutathione peroxidase 3
H2AFX H2A histone family, member X
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HAMP hepcidin antimicrobial peptide
HAVCR1 hepatitis A virus cellular receptor 1
HBA1 hemoglobin, alpha 1
HCAR1 hydroxycarboxylic acid receptor 1
HCAR2 hydroxycarboxylic acid receptor 2
HCAR3 hydroxycarboxylic acid receptor 3
HDAC4 histone deacetylase 4
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HP haptoglobin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IFI30 interferon, gamma-inducible protein 30
IFNA2 interferon, alpha 2
IFNB1 interferon, beta 1, fibroblast
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1RN interleukin 1 receptor antagonist
IL20 interleukin 20
IL6 interleukin 6
IL6R interleukin 6 receptor
INHA inhibin, alpha
INHBB inhibin, beta B
INS insulin
INSIG2 insulin induced gene 2
INSL3 insulin-like 3 (Leydig cell)
INSR insulin receptor
IRF1 interferon regulatory factor 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAD integrin, alpha D
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITLN1 intelectin 1 (galactofuranose binding)
JUN jun proto-oncogene
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KISS1 KiSS-1 metastasis-suppressor
KLK3 kallikrein-related peptidase 3
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEP leptin
LEPQTL1 Leptin, serum levels of
LEPR leptin receptor
LIPE lipase, hormone-sensitive
LPA lipoprotein, Lp(a)
LPIN1 lipin 1
LPL lipoprotein lipase
LTF lactotransferrin
MBOAT4 membrane bound O-acyltransferase domain containing 4
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MFN2 mitofusin 2
MGLL monoglyceride lipase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR181A1 microRNA 181a-1
MIR21 microRNA 21
MIR221 microRNA 221
MLXIPL MLX interacting protein-like
MMP2 matrix metallopeptidase 2
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSTN myostatin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1B melatonin receptor 1B
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MTTP microsomal triglyceride transfer protein
NAMPT nicotinamide phosphoribosyltransferase
NCOR2 nuclear receptor corepressor 2
NGF nerve growth factor (beta polypeptide)
NLRP3 NLR family, pyrin domain containing 3
NNT nicotinamide nucleotide transhydrogenase
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOV nephroblastoma overexpressed
NPBWR1 neuropeptides B/W receptor 1
NPC1L1 NPC1-like 1
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTN1 netrin 1
NUCB2 nucleobindin 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPRM1 opioid receptor, mu 1
ORM1 orosomucoid 1
OSBPL11 oxysterol binding protein-like 11
OXTR oxytocin receptor
PBX1 pre-B-cell leukemia homeobox 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE8B phosphodiesterase 8B
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PER2 period circadian clock 2
PGR progesterone receptor
PID1 phosphotyrosine interaction domain containing 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLAT plasminogen activator, tissue
PLIN1 perilipin 1
PNPLA2 patatin-like phospholipase domain containing 2
PNPLA3 patatin-like phospholipase domain containing 3
POMC proopiomelanocortin
PON1 paraoxonase 1
POSTN periostin, osteoblast specific factor
POU2F1 POU class 2 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPY pancreatic polypeptide
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCD protein kinase C, delta
PRL prolactin
PTEN phosphatase and tensin homolog
PTH parathyroid hormone
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTX3 pentraxin 3, long
PYY peptide YY
RARG retinoic acid receptor, gamma
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RETN resistin
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RFC1 replication factor C (activator 1) 1, 145kDa
RIPK3 receptor-interacting serine-threonine kinase 3
RNF216 ring finger protein 216
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
SAA1 serum amyloid A1
SAA@ serum amyloid A1 cluster
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMG1 semenogelin I
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP5 secreted frizzled-related protein 5
SH2B1 SH2B adaptor protein 1
SHBG sex hormone-binding globulin
SIRT2 sirtuin 2
SIRT4 sirtuin 4
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC39A3 solute carrier family 39 (zinc transporter), member 3
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SREBF1 sterol regulatory element binding transcription factor 1
STEAP4 STEAP family member 4
STS steroid sulfatase (microsomal), isozyme S
SULF2 sulfatase 2
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TBC1D22A TBC1 domain family, member 22A
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
THBS1 thrombospondin 1
THRA thyroid hormone receptor, alpha
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNNT2 troponin T type 2 (cardiac)
TP63 tumor protein p63
TRA2B transformer 2 beta homolog (Drosophila)
TRIB3 tribbles pseudokinase 3
TUB tubby bipartite transcription factor
TXNRD1 thioredoxin reductase 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UNC5B unc-5 homolog B (C. elegans)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
YY1 YY1 transcription factor