obesity Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An eating-related disorder in which excess body fat has accumulated to such an extent that health may be negatively affected. It is commonly defined as a body mass index (weight divided by height squared) of 30 kg/m2 or higher.|A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). (Experimental Factor Ontology, EFO_0001073)
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Genes

105 genes associated with the disease obesity in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
COBLL1 cordon-bleu WH2 repeat protein-like 1 1.86862
RSPO3 R-spondin 3 1.82071
VEGFA vascular endothelial growth factor A 1.61356
TBX15 T-box 15 1.55692
NFE2L3 nuclear factor, erythroid 2-like 3 1.55524
DNM3 dynamin 3 1.24299
PIGC phosphatidylinositol glycan anchor biosynthesis, class C 1.24299
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 1.22898
LIN7C lin-7 homolog C (C. elegans) 1.20753
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 1.14929
GNPDA2 glucosamine-6-phosphate deaminase 2 1.13588
HOXC13 homeobox C13 1.1139
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.790827
ZNRF3 zinc and ring finger 3 0.774217
SH2B1 SH2B adaptor protein 1 0.752991
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.682635
NISCH nischarin 0.670996
OLFM4 olfactomedin 4 0.602429
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.602429
HOXB5 homeobox B5 0.572184
MTCH2 mitochondrial carrier 2 0.561725
MSRA methionine sulfoxide reductase A 0.5306
PAX5 paired box 5 0.5306
KCTD15 potassium channel tetramerization domain containing 15 0.486425
RPS17P5 ribosomal protein S17 pseudogene 5 0.464771
SLC30A10 solute carrier family 30, member 10 0.464771
NCAM2 neural cell adhesion molecule 2 0.449873
MRPS22 mitochondrial ribosomal protein S22 0.438544
NRXN3 neurexin 3 0.438544
NEGR1 neuronal growth regulator 1 0.429338
SPRY2 sprouty homolog 2 (Drosophila) 0.4215
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.414708
FTO fat mass and obesity associated 0.403461
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.403461
CHD2 chromodomain helicase DNA binding protein 2 0.368757
GDAP1 ganglioside induced differentiation associated protein 1 0.368757
INHBB inhibin, beta B 0.368757
MC4R melanocortin 4 receptor 0.368757
ARG1 arginase 1 0.345945
NPC1 Niemann-Pick disease, type C1 0.345945
TBCE tubulin folding cofactor E 0.345945
BCDIN3D BCDIN3 domain containing 0.327313
SOX6 SRY (sex determining region Y)-box 6 0.327313
TTC28 tetratricopeptide repeat domain 28 0.285417
PCDH9 protocadherin 9 0.285417
LHFPL3 lipoma HMGIC fusion partner-like 3 0.285417
WWOX WW domain containing oxidoreductase 0.274608
ZNF248 zinc finger protein 248 0.264872
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.256228
SV2C synaptic vesicle glycoprotein 2C 0.256228
ALPK1 alpha-kinase 1 0.256228
EML6 echinoderm microtubule associated protein like 6 0.256228
CMYA5 cardiomyopathy associated 5 0.256228
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.256228
STK33 serine/threonine kinase 33 0.256228
FAIM2 Fas apoptotic inhibitory molecule 2 0.197766
CAMK1G calcium/calmodulin-dependent protein kinase IG 0.197766
MAP1A microtubule-associated protein 1A 0.197766
SFRP2 secreted frizzled-related protein 2 0.197766
DARS aspartyl-tRNA synthetase 0.197766
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.197766
EIF4E3 eukaryotic translation initiation factor 4E family member 3 0.15771
HOXB1 homeobox B1 0.15771
EXOC4 exocyst complex component 4 0.15771
ANO3 anoctamin 3 0.126165
PKP1 plakophilin 1 0.126165
COL21A1 collagen, type XXI, alpha 1 0.126165
APOC1 apolipoprotein C-I 0.126165
RARB retinoic acid receptor, beta 0.126165
ANKDD1B ankyrin repeat and death domain containing 1B 0.126165
MEX3B mex-3 RNA binding family member B 0.126165
LCT lactase 0.126165
FBN2 fibrillin 2 0.126165
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.126165
MDFIC MyoD family inhibitor domain containing 0.126165
MACROD2 MACRO domain containing 2 0.100789
DIRAS2 DIRAS family, GTP-binding RAS-like 2 0.100789
PFKP phosphofructokinase, platelet 0.100789
KDM4C lysine (K)-specific demethylase 4C 0.100789
OVCH2 ovochymase 2 (gene/pseudogene) 0.100789
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.100789
RGS6 regulator of G-protein signaling 6 0.100789
RFTN1 raftlin, lipid raft linker 1 0.100789
PALD1 phosphatase domain containing, paladin 1 0.100789
ARHGAP12 Rho GTPase activating protein 12 0.080593
MLN motilin 0.080593
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.080593
HDAC4 histone deacetylase 4 0.080593
THEMIS thymocyte selection associated 0.080593
FAT1 FAT atypical cadherin 1 0.064973
TRUB2 TruB pseudouridine (psi) synthase family member 2 0.064973
KCTD8 potassium channel tetramerization domain containing 8 0.064973
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.064973
LIPA lipase A, lysosomal acid, cholesterol esterase 0.064973
IFITM8P interferon induced transmembrane protein 8 pseudogene 0.064973
POC5 POC5 centriolar protein 0.052255
C9ORF84 chromosome 9 open reading frame 84 0.052255
INO80D INO80 complex subunit D 0.052255
CYB5R2 cytochrome b5 reductase 2 0.052255
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.052255
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 0.052255
NRXN1 neurexin 1 0.052255
C8ORF37 chromosome 8 open reading frame 37 0.043246
HOXB3 homeobox B3 0.043246
SACK1B scaffolding CK1 anchoring protein B 0.043246