obesity Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An eating-related disorder in which excess body fat has accumulated to such an extent that health may be negatively affected. It is commonly defined as a body mass index (weight divided by height squared) of 30 kg/m2 or higher.|A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). (Experimental Factor Ontology, EFO_0001073)
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Genes

248 genes co-occuring with the disease obesity in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MC4R melanocortin 4 receptor 2.31276
LEP leptin 2.24364
INS insulin 1.85912
GHRL ghrelin/obestatin prepropeptide 1.78038
LEPR leptin receptor 1.75641
SIM1 single-minded family bHLH transcription factor 1 1.601
FTO fat mass and obesity associated 1.40789
PYY peptide YY 1.32934
MC3R melanocortin 3 receptor 1.28872
SH2B1 SH2B adaptor protein 1 1.19964
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 1.18109
PCSK1 proprotein convertase subtilisin/kexin type 1 1.16606
CRP C-reactive protein, pentraxin-related 1.1422
RETN resistin 1.14009
AGRP agouti related neuropeptide 1.12909
ADRB3 adrenoceptor beta 3 1.11856
NEGR1 neuronal growth regulator 1 1.05892
TBC1D14 TBC1 domain family, member 14 1.04377
INSIG2 insulin induced gene 2 1.02608
PTH parathyroid hormone 1.01934
AQP7 aquaporin 7 1.01132
MRAP2 melanocortin 2 receptor accessory protein 2 1.01132
PPY pancreatic polypeptide 0.949519
PPARG peroxisome proliferator-activated receptor gamma 0.945354
OSBPL11 oxysterol binding protein-like 11 0.930828
POMC proopiomelanocortin 0.925452
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 0.917199
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.874919
GIP gastric inhibitory polypeptide 0.863046
ALB albumin 0.847488
APMAP adipocyte plasma membrane associated protein 0.827409
CCK cholecystokinin 0.815924
SEC16B SEC16 homolog B (S. cerevisiae) 0.81059
KCTD15 potassium channel tetramerization domain containing 15 0.808129
GGT6 gamma-glutamyltransferase 6 0.801974
SHBG sex hormone-binding globulin 0.790081
GCG glucagon 0.785574
NAMPT nicotinamide phosphoribosyltransferase 0.770027
FABP2 fatty acid binding protein 2, intestinal 0.752085
HCRT hypocretin (orexin) neuropeptide precursor 0.73746
MCHR2 melanin-concentrating hormone receptor 2 0.733001
GNPDA2 glucosamine-6-phosphate deaminase 2 0.731786
LIPE lipase, hormone-sensitive 0.731381
TULP2 tubby like protein 2 0.71925
KIAA1462 KIAA1462 0.716425
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 0.692697
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.691094
LIPF lipase, gastric 0.677903
MTCH2 mitochondrial carrier 2 0.676706
IGF1 insulin-like growth factor 1 (somatomedin C) 0.66596
NPY neuropeptide Y 0.647348
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.639463
LPL lipoprotein lipase 0.637495
TNF tumor necrosis factor 0.633169
ADIPOR2 adiponectin receptor 2 0.629242
IGLV3-21 immunoglobulin lambda variable 3-21 0.626495
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.626103
CD79B CD79b molecule, immunoglobulin-associated beta 0.623359
IL6 interleukin 6 0.622575
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.622183
SREBF1 sterol regulatory element binding transcription factor 1 0.618268
NTS neurotensin 0.617486
FTL ferritin, light polypeptide 0.614356
FTH1 ferritin, heavy polypeptide 1 0.614356
CTNNBL1 catenin, beta like 1 0.608494
KISS1 KiSS-1 metastasis-suppressor 0.608104
GAST gastrin 0.597571
PRLHR prolactin releasing hormone receptor 0.588222
FAAH fatty acid amide hydrolase 0.582773
ALPPL2 alkaline phosphatase, placental-like 2 0.576939
ALPP alkaline phosphatase, placental 0.57655
ALPL alkaline phosphatase, liver/bone/kidney 0.575772
TTR transthyretin 0.572662
COG2 component of oligomeric golgi complex 2 0.572273
BBS4 Bardet-Biedl syndrome 4 0.571495
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.566443
ITLN1 intelectin 1 (galactofuranose binding) 0.557509
INSR insulin receptor 0.556344
LYPLAL1 lysophospholipase-like 1 0.549747
PACS1 phosphofurin acidic cluster sorting protein 1 0.545868
GNAS GNAS complex locus 0.518805
ARL6 ADP-ribosylation factor-like 6 0.509576
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.509576
DSE dermatan sulfate epimerase 0.509192
IL18 interleukin 18 0.504207
MTPAP mitochondrial poly(A) polymerase 0.503058
BBS1 Bardet-Biedl syndrome 1 0.498849
GGT1 gamma-glutamyltransferase 1 0.497321
IRS1 insulin receptor substrate 1 0.494266
CCL2 chemokine (C-C motif) ligand 2 0.490835
PNPLA3 patatin-like phospholipase domain containing 3 0.484364
GHRH growth hormone releasing hormone 0.483224
GLP1R glucagon-like peptide 1 receptor 0.482844
NPS neuropeptide S 0.482084
SEC24B SEC24 family member B 0.468819
BDNF brain-derived neurotrophic factor 0.468063
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.467306
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.463905
MLN motilin 0.457864
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 0.455601
PROKR1 prokineticin receptor 1 0.45447
CDCA8 cell division cycle associated 8 0.4443
FNDC5 fibronectin type III domain containing 5 0.443547
RBP4 retinol binding protein 4, plasma 0.439786
PLIN1 perilipin 1 0.437154
PNMA1 paraneoplastic Ma antigen 1 0.436402
CRTC1 CREB regulated transcription coactivator 1 0.436402
ETV5 ets variant 5 0.433772
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.431894
RPGRIP1L RPGRIP1-like 0.424014
STEAP4 STEAP family member 4 0.42214
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.421765
APOB apolipoprotein B 0.419892
BSX brain-specific homeobox 0.418019
GGTLC1 gamma-glutamyltransferase light chain 1 0.415398
NTF4 neurotrophin 4 0.411283
DOCK5 dedicator of cytokinesis 5 0.408292
SIRT1 sirtuin 1 0.407919
GGT2 gamma-glutamyltransferase 2 0.398962
PLG plasminogen 0.394491
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.388538
FAM120A family with sequence similarity 120A 0.385936
SP6 Sp6 transcription factor 0.380368
STXBP3 syntaxin binding protein 3 0.378885
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.372217
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.369997
GGT5 gamma-glutamyltransferase 5 0.369628
IRS2 insulin receptor substrate 2 0.365562
NPY2R neuropeptide Y receptor Y2 0.362978
NMUR2 neuromedin U receptor 2 0.359657
GANAB glucosidase, alpha; neutral AB 0.358183
SPON2 spondin 2, extracellular matrix protein 0.355972
PLIN5 perilipin 5 0.354131
GLYAT glycine-N-acyltransferase 0.353027
AHSG alpha-2-HS-glycoprotein 0.351187
PCTP phosphatidylcholine transfer protein 0.349349
ARL13B ADP-ribosylation factor-like 13B 0.346777
FABP4 fatty acid binding protein 4, adipocyte 0.344207
CNR1 cannabinoid receptor 1 (brain) 0.343473
GGT7 gamma-glutamyltransferase 7 0.343106
TMEM18 transmembrane protein 18 0.341639
GPS2 G protein pathway suppressor 2 0.337242
GLUD1 glutamate dehydrogenase 1 0.333218
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.327375
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.325552
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.325187
CHD8 chromodomain helicase DNA binding protein 8 0.325187
DGKZ diacylglycerol kinase, zeta 0.324823
ADIPOR1 adiponectin receptor 1 0.322637
ALMS1 Alstrom syndrome protein 1 0.320454
GCK glucokinase (hexokinase 4) 0.319726
GPS1 G protein pathway suppressor 1 0.317182
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 0.315366
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.315366
ZNF148 zinc finger protein 148 0.309928
ADIPOQ adiponectin, C1Q and collagen domain containing 0.309566
EXOSC4 exosome component 4 0.307033
PRLH prolactin releasing hormone 0.305948
GLS2 glutaminase 2 (liver, mitochondrial) 0.305587
ERH enhancer of rudimentary homolog (Drosophila) 0.304864
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.304503
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.301976
IRS4 insulin receptor substrate 4 0.301615
PTER phosphotriesterase related 0.300173
PRAMEF12 PRAME family member 12 0.299092
OSBP oxysterol binding protein 0.295851
RAB11A RAB11A, member RAS oncogene family 0.291898
MC5R melanocortin 5 receptor 0.288668
NPC1 Niemann-Pick disease, type C1 0.286519
KIF1B kinesin family member 1B 0.28151
CD36 CD36 molecule (thrombospondin receptor) 0.272953
RTN1 reticulon 1 0.272597
AKTIP AKT interacting protein 0.268687
HOXB5 homeobox B5 0.268687
FOXJ2 forkhead box J2 0.268687
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.266558
LSM1 LSM1, U6 small nuclear RNA associated 0.26514
ENSA endosulfine alpha 0.25877
ITGAD integrin, alpha D 0.258417
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.254183
PNPLA2 patatin-like phospholipase domain containing 2 0.24996
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.248203
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.247501
HADH hydroxyacyl-CoA dehydrogenase 0.247501
PRKCH protein kinase C, eta 0.24715
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.244696
IL33 interleukin 33 0.244345
MT1E metallothionein 1E 0.242945
SDC3 syndecan 3 0.23666
NRG1 neuregulin 1 0.235964
CCKAR cholecystokinin A receptor 0.235268
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.234573
ANGPTL4 angiopoietin-like 4 0.234225
NRXN3 neurexin 3 0.233183
ADRA2B adrenoceptor alpha 2B 0.230755
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.230755
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.230755
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.226952
TRAPPC9 trafficking protein particle complex 9 0.223853
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.223165
BBS12 Bardet-Biedl syndrome 12 0.22145
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.220424
ACACB acetyl-CoA carboxylase beta 0.218374
BBS10 Bardet-Biedl syndrome 10 0.218034
PRRC2A proline-rich coiled-coil 2A 0.217693
LRRC38 leucine rich repeat containing 38 0.217352
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.216672
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.214297
MIR130B microRNA 130b 0.213959
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.212271
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.211597
NRIP1 nuclear receptor interacting protein 1 0.210589
APOA1 apolipoprotein A-I 0.208245
GANC glucosidase, alpha; neutral C 0.203604
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.201962
FAIM2 Fas apoptotic inhibitory molecule 2 0.200331
BRD2 bromodomain containing 2 0.198709
APOA2 apolipoprotein A-II 0.198064
UBA1 ubiquitin-like modifier activating enzyme 1 0.198064
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.197742
RFX5 regulatory factor X, 5 (influences HLA class II expression) 0.197099
NNAT neuronatin 0.194865
TF transferrin 0.190168
ICK intestinal cell (MAK-like) kinase 0.188938
LCT lactase 0.188022
MCHR1 melanin-concentrating hormone receptor 1 0.187113
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.185016
F2 coagulation factor II (thrombin) 0.185016
AQP9 aquaporin 9 0.183835
DPP4 dipeptidyl-peptidase 4 0.183248
MT1A metallothionein 1A 0.178403
TMEM245 transmembrane protein 245 0.172038
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.170544
OLFM4 olfactomedin 4 0.16933
DMRTA1 DMRT-like family A1 0.169091
GIF gastric intrinsic factor (vitamin B synthesis) 0.169091
ADRB2 adrenoceptor beta 2, surface 0.167682
ADCY3 adenylate cyclase 3 0.167682
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 0.167452
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.165655
PNLIP pancreatic lipase 0.164571
SOCS3 suppressor of cytokine signaling 3 0.163317
SST somatostatin 0.162908
GSR glutathione reductase 0.162109
SDF4 stromal cell derived factor 4 0.161331
SNAP25 synaptosomal-associated protein, 25kDa 0.160948
PEX10 peroxisomal biogenesis factor 10 0.158266
CD40LG CD40 ligand 0.157929