obesity Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An eating-related disorder in which excess body fat has accumulated to such an extent that health may be negatively affected. It is commonly defined as a body mass index (weight divided by height squared) of 30 kg/m2 or higher.|A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). (Experimental Factor Ontology, EFO_0001073)
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Genes

74 proteins co-occuring with the biological term obesity in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
AKT1 v-akt murine thymoma viral oncogene homolog 1
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
CDK5 cyclin-dependent kinase 5
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CREB1 cAMP responsive element binding protein 1
CRTC2 CREB regulated transcription coactivator 2
CTTN cortactin
DGAT1 diacylglycerol O-acyltransferase 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK1 ELK1, member of ETS oncogene family
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
ERN1 endoplasmic reticulum to nucleus signaling 1
FOXO1 forkhead box O1
GATA2 GATA binding protein 2
GRB14 growth factor receptor-bound protein 14
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GYS1 glycogen synthase 1 (muscle)
HDAC5 histone deacetylase 5
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IFNAR1 interferon (alpha, beta and omega) receptor 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INSR insulin receptor
IPMK inositol polyphosphate multikinase
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK2 Janus kinase 2
LEPR leptin receptor
LIPE lipase, hormone-sensitive
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MC4R melanocortin 4 receptor
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NOS3 nitric oxide synthase 3 (endothelial cell)
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RYR2 ryanodine receptor 2 (cardiac)
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STXBP3 syntaxin binding protein 3
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TSC2 tuberous sclerosis 2
XBP1 X-box binding protein 1