ofloxacin-7372 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the ofloxacin-7372 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY6 adenylate cyclase 6
ADGRL1 adhesion G protein-coupled receptor L1
ANXA10 annexin A10
ANXA2P3 annexin A2 pseudogene 3
APOLD1 apolipoprotein L domain containing 1
ARHGAP35 Rho GTPase activating protein 35
ARID1A AT rich interactive domain 1A (SWI-like)
ATP7B ATPase, Cu++ transporting, beta polypeptide
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC9 coiled-coil domain containing 9
CEP131 centrosomal protein 131kDa
CLCN6 chloride channel, voltage-sensitive 6
CLEC4E C-type lectin domain family 4, member E
COL4A6 collagen, type IV, alpha 6
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CPT1A carnitine palmitoyltransferase 1A (liver)
CSPP1 centrosome and spindle pole associated protein 1
CTC1 CTS telomere maintenance complex component 1
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDN dendrin
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLG4 discs, large homolog 4 (Drosophila)
DUSP9 dual specificity phosphatase 9
ECE1 endothelin converting enzyme 1
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FGFR2 fibroblast growth factor receptor 2
FKBP8 FK506 binding protein 8, 38kDa
FMOD fibromodulin
FOSL2 FOS-like antigen 2
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GLRB glycine receptor, beta
GPR137 G protein-coupled receptor 137
GPSM3 G-protein signaling modulator 3
GRK6 G protein-coupled receptor kinase 6
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HSF2BP heat shock transcription factor 2 binding protein
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGLJ3 immunoglobulin lambda joining 3
INSR insulin receptor
IRAK4 interleukin-1 receptor-associated kinase 4
KIF5C kinesin family member 5C
LEF1 lymphoid enhancer-binding factor 1
LIMK2 LIM domain kinase 2
LTBP4 latent transforming growth factor beta binding protein 4
MRPL57 mitochondrial ribosomal protein L57
NF2 neurofibromin 2 (merlin)
NPR3 natriuretic peptide receptor 3
PCCA propionyl CoA carboxylase, alpha polypeptide
PCOLCE procollagen C-endopeptidase enhancer
PDS5A PDS5 cohesin associated factor A
PRR4 proline rich 4 (lacrimal)
PVR poliovirus receptor
PVT1 Pvt1 oncogene (non-protein coding)
RAB31 RAB31, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAD52 RAD52 homolog (S. cerevisiae)
RBMS3 RNA binding motif, single stranded interacting protein 3
RHOT2 ras homolog family member T2
RNASE4 ribonuclease, RNase A family, 4
RNF126P1 ring finger protein 126 pseudogene 1
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPS3A ribosomal protein S3A
RUSC2 RUN and SH3 domain containing 2
SDC2 syndecan 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SMG6 SMG6 nonsense mediated mRNA decay factor
SND1-IT1 SND1 intronic transcript 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SUGP1 SURP and G patch domain containing 1
TAOK2 TAO kinase 2
TAPBP TAP binding protein (tapasin)
TBL1Y transducin (beta)-like 1, Y-linked
TBX2 T-box 2
TESK1 testis-specific kinase 1
TGFA transforming growth factor, alpha
TJAP1 tight junction associated protein 1 (peripheral)
TLN2 talin 2
TMEM121 transmembrane protein 121
TMEM63A transmembrane protein 63A
TRAPPC13 trafficking protein particle complex 13
TRAPPC6A trafficking protein particle complex 6A
TUBA3C tubulin, alpha 3c
UBE3B ubiquitin protein ligase E3B
WNT5A wingless-type MMTV integration site family, member 5A
XDH xanthine dehydrogenase
YY1 YY1 transcription factor
ZNF174 zinc finger protein 174
ZNF224 zinc finger protein 224
ZNF358 zinc finger protein 358
ZNF428 zinc finger protein 428
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
AFAP1 actin filament associated protein 1
AKTIP AKT interacting protein
ALPK1 alpha-kinase 1
APOL6 apolipoprotein L, 6
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARMC6 armadillo repeat containing 6
ASB7 ankyrin repeat and SOCS box containing 7
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAK1 BCL2-antagonist/killer 1
BCAS3 breast carcinoma amplified sequence 3
BIRC3 baculoviral IAP repeat containing 3
BTBD2 BTB (POZ) domain containing 2
C16ORF59 chromosome 16 open reading frame 59
C19ORF54 chromosome 19 open reading frame 54
C9ORF114 chromosome 9 open reading frame 114
CARD8 caspase recruitment domain family, member 8
CCDC68 coiled-coil domain containing 68
CCNO cyclin O
CCS copper chaperone for superoxide dismutase
CDON cell adhesion associated, oncogene regulated
CENPO centromere protein O
CHM choroideremia (Rab escort protein 1)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC10A C-type lectin domain family 10, member A
CLEC2B C-type lectin domain family 2, member B
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSK cathepsin K
DBR1 debranching RNA lariats 1
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ELOVL4 ELOVL fatty acid elongase 4
ELP6 elongator acetyltransferase complex subunit 6
ELSPBP1 epididymal sperm binding protein 1
FAM50B family with sequence similarity 50, member B
FBXL2 F-box and leucine-rich repeat protein 2
GALK1 galactokinase 1
GDAP1 ganglioside induced differentiation associated protein 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H1E histone cluster 1, H1e
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BJ histone cluster 1, H2bj
INF2 inverted formin, FH2 and WH2 domain containing
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITPKC inositol-trisphosphate 3-kinase C
KLF2 Kruppel-like factor 2
KRT6A keratin 6A, type II
LNPEP leucyl/cystinyl aminopeptidase
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LONRF3 LON peptidase N-terminal domain and ring finger 3
MAST3 microtubule associated serine/threonine kinase 3
MBTD1 mbt domain containing 1
MDFI MyoD family inhibitor
MOXD1 monooxygenase, DBH-like 1
NHLRC2 NHL repeat containing 2
NOL12 nucleolar protein 12
NRBP1 nuclear receptor binding protein 1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PARM1 prostate androgen-regulated mucin-like protein 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX26 peroxisomal biogenesis factor 26
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
REEP4 receptor accessory protein 4
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF31 ring finger protein 31
RUNX1-IT1 RUNX1 intronic transcript 1
SAMHD1 SAM domain and HD domain 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SERTAD3 SERTA domain containing 3
SH2D4A SH2 domain containing 4A
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SMA4 glucuronidase, beta pseudogene
SMAD7 SMAD family member 7
SPAG7 sperm associated antigen 7
SPEG SPEG complex locus
TLR2 toll-like receptor 2
TMEM8A transmembrane protein 8A
TMEM8B transmembrane protein 8B
TNS2 tensin 2
TSPYL2 TSPY-like 2
TSSC4 tumor suppressing subtransferable candidate 4
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YOD1 YOD1 deubiquitinase
ZBTB48 zinc finger and BTB domain containing 48
ZNF253 zinc finger protein 253
ZNF408 zinc finger protein 408
ZNF480 zinc finger protein 480