okadaic-acid Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
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Genes

76 genes differentially expressed following the okadaic-acid small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
FOS FBJ murine osteosarcoma viral oncogene homolog 14.2411
EGR1 early growth response 1 11.1609
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 8.93088
FOSB FBJ murine osteosarcoma viral oncogene homolog B 8.68464
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 7.80599
GADD45B growth arrest and DNA-damage-inducible, beta 7.51624
CXCR4 chemokine (C-X-C motif) receptor 4 7.438
JUNB jun B proto-oncogene 6.91634
NR4A2 nuclear receptor subfamily 4, group A, member 2 6.3571
HES1 hes family bHLH transcription factor 1 6.10108
BTG2 BTG family, member 2 5.85329
ZFP36 ZFP36 ring finger protein 5.82925
JUN jun proto-oncogene 5.78127
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 5.67262
IER2 immediate early response 2 5.65017
NR4A1 nuclear receptor subfamily 4, group A, member 1 5.49209
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 5.30623
BAMBI BMP and activin membrane-bound inhibitor 5.11413
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 4.95459
ATF3 activating transcription factor 3 4.74252
EGR3 early growth response 3 4.70301
CCNA2 cyclin A2 4.5848
GAPDH glyceraldehyde-3-phosphate dehydrogenase 4.57271
SIK1 salt-inducible kinase 1 4.44677
MCM2 minichromosome maintenance complex component 2 4.3982
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 4.2976
DUSP2 dual specificity phosphatase 2 4.25554
KLF6 Kruppel-like factor 6 4.23378
NR4A3 nuclear receptor subfamily 4, group A, member 3 4.1725
MCL1 myeloid cell leukemia 1 3.96577
RHOB ras homolog family member B 3.95757
APOLD1 apolipoprotein L domain containing 1 3.94126
CXCL2 chemokine (C-X-C motif) ligand 2 3.94102
ZC3H12A zinc finger CCCH-type containing 12A 3.92568
KLHL21 kelch-like family member 21 3.90123
SOCS3 suppressor of cytokine signaling 3 3.86904
TOB2 transducer of ERBB2, 2 3.86026
TRIB1 tribbles pseudokinase 1 3.71391
MIR22HG MIR22 host gene 3.70461
DUSP1 dual specificity phosphatase 1 3.67447
KDM5B lysine (K)-specific demethylase 5B 3.65341
RGS1 regulator of G-protein signaling 1 3.61469
MAP3K8 mitogen-activated protein kinase kinase kinase 8 3.55315
KLF2 Kruppel-like factor 2 3.51843
KLF4 Kruppel-like factor 4 (gut) 3.5133
ALAS1 5'-aminolevulinate synthase 1 3.50418
GADD45G growth arrest and DNA-damage-inducible, gamma 3.48582
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.46964
HBEGF heparin-binding EGF-like growth factor 3.46672
CBR3 carbonyl reductase 3 3.38773
PPP1R15A protein phosphatase 1, regulatory subunit 15A 3.33498
INSIG1 insulin induced gene 1 3.33249
RGS2 regulator of G-protein signaling 2 3.2917
CEMIP2 cell migration inducing hyaluronidase 2 3.26076
KLF10 Kruppel-like factor 10 3.20206
TOB1 transducer of ERBB2, 1 3.19315
RND1 Rho family GTPase 1 3.17514
CXCL3 chemokine (C-X-C motif) ligand 3 3.15233
MAT2A methionine adenosyltransferase II, alpha 3.14547
IER5 immediate early response 5 3.11657
PLAUR plasminogen activator, urokinase receptor 3.10812
IP6K2 inositol hexakisphosphate kinase 2 3.08384
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 3.07515
IER3 immediate early response 3 3.07285
KIF23 kinesin family member 23 3.06611
IVNS1ABP influenza virus NS1A binding protein 3.05764

decreased expression

Symbol Name Standardized Value
TOP2A topoisomerase (DNA) II alpha 170kDa -4.12029
CSNK2B casein kinase 2, beta polypeptide -3.43515
PTGES prostaglandin E synthase -3.41994
SRPRB signal recognition particle receptor, B subunit -3.3283
ST20 suppressor of tumorigenicity 20 -3.21986
TOPBP1 topoisomerase (DNA) II binding protein 1 -3.15195
TMEM33 transmembrane protein 33 -3.14691
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -3.09737
GRB10 growth factor receptor-bound protein 10 -3.07938
XPOT exportin, tRNA -3.04712