| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | olaparib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the olaparib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FBN1 | fibrillin 1 | 0.147212 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.147013 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.102578 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0950824 |
| COL3A1 | collagen, type III, alpha 1 | 0.0857389 |
| COL1A2 | collagen, type I, alpha 2 | 0.078806 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0725482 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0662781 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0647318 |
| DST | dystonin | 0.0642336 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0620251 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0602481 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0600842 |
| GPC6 | glypican 6 | 0.0553064 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0543167 |
| PRELID2 | PRELI domain containing 2 | 0.0528388 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0471789 |
| SBF2 | SET binding factor 2 | 0.0453073 |
| COL5A2 | collagen, type V, alpha 2 | 0.0448752 |
| LOXL2 | lysyl oxidase-like 2 | 0.0441752 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0432073 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0410987 |
| MB21D2 | Mab-21 domain containing 2 | 0.040864 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0406067 |
| TENM3 | teneurin transmembrane protein 3 | 0.0376958 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0374725 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0373614 |
| MEIS2 | Meis homeobox 2 | 0.0361473 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0356769 |
| KIFAP3 | kinesin-associated protein 3 | 0.0355091 |
| GASK1B | golgi associated kinase 1B | 0.0351415 |
| ANK2 | ankyrin 2, neuronal | 0.0341354 |
| ARRDC3 | arrestin domain containing 3 | 0.0338939 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0337233 |
| OGA | O-GlcNAcase | 0.0335497 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0327381 |
| RAI14 | retinoic acid induced 14 | 0.0321406 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0315379 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0314155 |
| ATP13A3 | ATPase type 13A3 | 0.0309205 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0296675 |
| APP | amyloid beta (A4) precursor protein | 0.0293055 |
| OPTN | optineurin | 0.0283921 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0283275 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0281359 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0278213 |
| TXNIP | thioredoxin interacting protein | 0.0272877 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0269526 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0265717 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0262656 |
| CDK19 | cyclin-dependent kinase 19 | 0.0261806 |
| FAM13A | family with sequence similarity 13, member A | 0.0259054 |
| FRMD5 | FERM domain containing 5 | 0.0255772 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0254633 |
| FNIP1 | folliculin interacting protein 1 | 0.0252369 |
| ZNF292 | zinc finger protein 292 | 0.0249255 |
| MYOF | myoferlin | 0.0248703 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0242175 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0239307 |
| NEK7 | NIMA-related kinase 7 | 0.0236965 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0236845 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.0236061 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0235599 |
| GLIS3 | GLIS family zinc finger 3 | 0.0234207 |
| RNF145 | ring finger protein 145 | 0.0233301 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.022938 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0224769 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0224126 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0222691 |
| METTL15 | methyltransferase like 15 | 0.0218631 |
| ARFGEF3 | ARFGEF family member 3 | 0.0217822 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0217813 |
| CLU | clusterin | 0.0215798 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0214352 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.0214109 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0213182 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0211067 |
| SMYD3 | SET and MYND domain containing 3 | 0.021038 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0206368 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0205333 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0205185 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0204537 |
| PRRX1 | paired related homeobox 1 | 0.0201052 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0199805 |
| UBC | ubiquitin C | 0.019697 |
| YEATS2 | YEATS domain containing 2 | 0.0196712 |
| MKX | mohawk homeobox | 0.0196342 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0194706 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0192704 |
| DCLK2 | doublecortin-like kinase 2 | 0.0192224 |
| MRTFA | myocardin related transcription factor A | 0.0188761 |
| PRKD3 | protein kinase D3 | 0.0188436 |
| VMP1 | vacuole membrane protein 1 | 0.0188325 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0188296 |
| MYO9A | myosin IXA | 0.0188182 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0187063 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0184372 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0180654 |
| AUTS2 | autism susceptibility candidate 2 | 0.0180642 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0180576 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.18959 |
| PODXL | podocalyxin-like | -0.164448 |
| CDH13 | cadherin 13 | -0.162663 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.148852 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.134637 |
| TMSB10 | thymosin beta 10 | -0.121268 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.106219 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.105037 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0951206 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0866554 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.086325 |
| COL5A1 | collagen, type V, alpha 1 | -0.0729313 |
| CCND1 | cyclin D1 | -0.072096 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0704456 |
| LOX | lysyl oxidase | -0.0697571 |
| CSTB | cystatin B (stefin B) | -0.0668285 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0638165 |
| FN1 | fibronectin 1 | -0.0610413 |
| S100A10 | S100 calcium binding protein A10 | -0.0579758 |
| MT2A | metallothionein 2A | -0.0567539 |
| PLAT | plasminogen activator, tissue | -0.0532841 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0521762 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0517872 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0494058 |
| MAP1B | microtubule-associated protein 1B | -0.0482187 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0447128 |
| LMNA | lamin A/C | -0.0445995 |
| EFNA5 | ephrin-A5 | -0.0436421 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0429442 |
| NDRG1 | N-myc downstream regulated 1 | -0.0426048 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0412067 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0411414 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.040228 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0402199 |
| PKM | pyruvate kinase, muscle | -0.0390499 |
| NAV2 | neuron navigator 2 | -0.0376422 |
| TAGLN2 | transgelin 2 | -0.0376251 |
| ACTG1 | actin gamma 1 | -0.0363776 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0362759 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0362134 |
| POTEF | POTE ankyrin domain family, member F | -0.0358569 |
| FTL | ferritin, light polypeptide | -0.0349469 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0347684 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0347487 |
| MSI2 | musashi RNA-binding protein 2 | -0.0337512 |
| MYADM | myeloid-associated differentiation marker | -0.0328483 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0327109 |
| FLNA | filamin A, alpha | -0.0326379 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0323026 |
| PTMA | prothymosin, alpha | -0.0311236 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0304388 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0301161 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0299213 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0296374 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0296224 |
| RIGI | RNA sensor RIG-I | -0.0288554 |
| RPL28 | ribosomal protein L28 | -0.0287983 |
| PRSS23 | protease, serine, 23 | -0.0287753 |
| S100A11 | S100 calcium binding protein A11 | -0.0283887 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0282789 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0281044 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0279354 |
| CYTH3 | cytohesin 3 | -0.0278661 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0276215 |
| CALR | calreticulin | -0.0272368 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0266801 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0266615 |
| CANX | calnexin | -0.0260805 |
| EGFR | epidermal growth factor receptor | -0.0259393 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0254109 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0251429 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0251121 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0249685 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.024868 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0243861 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0237585 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0234962 |
| RPLP2 | ribosomal protein, large, P2 | -0.023027 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0229747 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.022628 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0222571 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0221993 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0221738 |
| FOSL1 | FOS-like antigen 1 | -0.0220828 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0220709 |
| PLXNA2 | plexin A2 | -0.0219811 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0219143 |
| L1CAM | L1 cell adhesion molecule | -0.0218982 |
| INTS6 | integrator complex subunit 6 | -0.0218498 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0216304 |
| ASPH | aspartate beta-hydroxylase | -0.0215777 |
| RPLP1 | ribosomal protein, large, P1 | -0.0211927 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0211244 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.0211084 |
| ENO1 | enolase 1, (alpha) | -0.0211058 |
| S100A6 | S100 calcium binding protein A6 | -0.0210964 |
| PFN1 | profilin 1 | -0.0208196 |
| RPS24 | ribosomal protein S24 | -0.0206644 |
| RPL23 | ribosomal protein L23 | -0.020292 |
| FSTL1 | follistatin-like 1 | -0.0201085 |
