olaparib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description olaparib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the olaparib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TENM3 teneurin transmembrane protein 3 0.126821
PTMA prothymosin, alpha 0.0790676
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0786933
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0764256
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0738872
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0697055
KDM3A lysine (K)-specific demethylase 3A 0.0580244
MGAT4C MGAT4 family, member C 0.0550623
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0550351
MED13L mediator complex subunit 13-like 0.0541923
DST dystonin 0.0534081
SYT1 synaptotagmin I 0.0525865
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0515421
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0505984
CXADR coxsackie virus and adenovirus receptor 0.0497665
ZBTB20 zinc finger and BTB domain containing 20 0.0494448
OXR1 oxidation resistance 1 0.0473411
XPO1 exportin 1 0.0462251
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0434418
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.042744
ZNF292 zinc finger protein 292 0.0409287
FTL ferritin, light polypeptide 0.0407886
CDK6 cyclin-dependent kinase 6 0.0405925
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0398732
NEK7 NIMA-related kinase 7 0.0394702
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0389648
CNRIP1 cannabinoid receptor interacting protein 1 0.0383507
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0380008
RPS8 ribosomal protein S8 0.037302
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0369403
RBM39 RNA binding motif protein 39 0.0369228
PUM2 pumilio RNA-binding family member 2 0.0363123
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0359728
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.035745
BCAS3 breast carcinoma amplified sequence 3 0.0356748
EPHA6 EPH receptor A6 0.0355667
KIF5B kinesin family member 5B 0.0352788
CPOX coproporphyrinogen oxidase 0.0346735
EPHA5 EPH receptor A5 0.0346476
CCSER1 coiled-coil serine-rich protein 1 0.0342854
FSTL5 follistatin-like 5 0.0334983
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0332246
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0321862
RPS27A ribosomal protein S27a 0.0321053
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0317187
OGA O-GlcNAcase 0.0310124
PNISR PNN-interacting serine/arginine-rich protein 0.0302429
ARHGAP12 Rho GTPase activating protein 12 0.0300359
SMYD3 SET and MYND domain containing 3 0.0295104
CDK19 cyclin-dependent kinase 19 0.0287969
ANKRD36 ankyrin repeat domain 36 0.0287247
KLHL24 kelch-like family member 24 0.0285234
PRKCI protein kinase C, iota 0.0278408
MATR3 matrin 3 0.0277765
RPL19 ribosomal protein L19 0.0276748
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0267253
PDGFC platelet derived growth factor C 0.0267221
TBC1D5 TBC1 domain family, member 5 0.0265224
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0262681
FXR1 fragile X mental retardation, autosomal homolog 1 0.0261245
MPG N-methylpurine-DNA glycosylase 0.0258223
BRWD3 bromodomain and WD repeat domain containing 3 0.0254916
ARRDC3 arrestin domain containing 3 0.0252475
ANXA1 annexin A1 0.0245322
AXIN2 axin 2 0.0244692
RPS19 ribosomal protein S19 0.024434
SETD5 SET domain containing 5 0.0242207
NAMPT nicotinamide phosphoribosyltransferase 0.024176
RPL26 ribosomal protein L26 0.0241306
GASK1B golgi associated kinase 1B 0.0241033
RPS12 ribosomal protein S12 0.0239115
EIF4B eukaryotic translation initiation factor 4B 0.0238341
TNPO1 transportin 1 0.023744
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0237235
PRR16 proline rich 16 0.0236924
RPS6 ribosomal protein S6 0.0235258
ZNF217 zinc finger protein 217 0.0233578
PHF21A PHD finger protein 21A 0.0232465
RPS2 ribosomal protein S2 0.0232168
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0230992
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0230575
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0229537
TXNRD1 thioredoxin reductase 1 0.0228665
THOC1 THO complex 1 0.0226116
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0225902
NCOA1 nuclear receptor coactivator 1 0.0221867
NRG1 neuregulin 1 0.0221516
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0220829
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0217679
RPS3 ribosomal protein S3 0.0217205
RPL37A ribosomal protein L37a 0.0216844
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0215567
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0215001
YEATS2 YEATS domain containing 2 0.0214341
CALR calreticulin 0.0212676
HSPB1 heat shock 27kDa protein 1 0.0209622
VCL vinculin 0.0208977
THSD7A thrombospondin, type I, domain containing 7A 0.0208645
HDAC9 histone deacetylase 9 0.0206751
AHNAK AHNAK nucleoprotein 0.0206603

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.200113
PCDH7 protocadherin 7 -0.13484
HMGA2 high mobility group AT-hook 2 -0.117409
EGR1 early growth response 1 -0.0952471
CCN2 cellular communication network factor 2 -0.088717
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0875346
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0843196
RAB7A RAB7A, member RAS oncogene family -0.0839112
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0793574
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0745863
AREG amphiregulin -0.0737461
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0687788
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0654065
BIRC3 baculoviral IAP repeat containing 3 -0.0631761
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0631375
ASPH aspartate beta-hydroxylase -0.0610885
ACTG1 actin gamma 1 -0.0525034
NHSL1 NHS-like 1 -0.0519718
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0513387
MARCHF4 membrane associated ring-CH-type finger 4 -0.0494664
JMJD1C jumonji domain containing 1C -0.0487415
POTEF POTE ankyrin domain family, member F -0.0475062
YAP1 Yes-associated protein 1 -0.0463518
BCHE butyrylcholinesterase -0.0457406
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0452547
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0438596
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0424475
EDARADD EDAR-associated death domain -0.0418049
ANKRD17 ankyrin repeat domain 17 -0.0410789
RASAL2 RAS protein activator like 2 -0.0408934
PFN1 profilin 1 -0.0402625
EHBP1 EH domain binding protein 1 -0.0395148
TUBA1B tubulin, alpha 1b -0.0386594
ADIPOR2 adiponectin receptor 2 -0.038607
HMGA1 high mobility group AT-hook 1 -0.0382491
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0354306
SLC38A2 solute carrier family 38, member 2 -0.0348242
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0347205
INTS6 integrator complex subunit 6 -0.0345311
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0337698
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0336114
CMIP c-Maf inducing protein -0.0332933
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0325072
LOC102724023 ES1 protein homolog, mitochondrial -0.0314379
SETX senataxin -0.0307502
RTN4 reticulon 4 -0.0303248
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0301189
LOC112694756 uncharaterized LOC112694756 -0.029828
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0298266
NAV3 neuron navigator 3 -0.0296236
TMEM41B transmembrane protein 41B -0.0296142
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0295634
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0276767
RCOR1 REST corepressor 1 -0.0267445
RHOA ras homolog family member A -0.0266753
DLC1 DLC1 Rho GTPase activating protein -0.0262858
CCND1 cyclin D1 -0.0261321
IPO7 importin 7 -0.0257562
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0256252
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0251664
EEF2 eukaryotic translation elongation factor 2 -0.0248779
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0245449
AFF4 AF4/FMR2 family, member 4 -0.0235608
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0235159
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0234744
KCMF1 potassium channel modulatory factor 1 -0.0232081
USP34 ubiquitin specific peptidase 34 -0.0230493
CLDN1 claudin 1 -0.0227785
ZNF804A zinc finger protein 804A -0.022393
ASXL2 additional sex combs like transcriptional regulator 2 -0.0219623
MSRB3 methionine sulfoxide reductase B3 -0.0213814
MYL12B myosin, light chain 12B, regulatory -0.0212234
STAU1 staufen double-stranded RNA binding protein 1 -0.0209567
BRD4 bromodomain containing 4 -0.0209347
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0209064
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0208783
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0208511
CSNK1A1 casein kinase 1, alpha 1 -0.0208246
WNK1 WNK lysine deficient protein kinase 1 -0.0207977
NABP1 nucleic acid binding protein 1 -0.0205868
GPHN gephyrin -0.0203492
PHACTR4 phosphatase and actin regulator 4 -0.0202969
AGO2 argonaute RISC catalytic component 2 -0.0201168
DENND5A DENN/MADD domain containing 5A -0.0198516
TEAD4 TEA domain family member 4 -0.0197943
RRM2 ribonucleotide reductase M2 -0.0197878
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.01928
MTAP methylthioadenosine phosphorylase -0.0191905
TM4SF1 transmembrane 4 L six family member 1 -0.018986
MAP1B microtubule-associated protein 1B -0.0189159
DUSP6 dual specificity phosphatase 6 -0.0185452
SLC38A1 solute carrier family 38, member 1 -0.0183632
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0182906
PRRC2A proline-rich coiled-coil 2A -0.0182775
AGO3 argonaute RISC catalytic component 3 -0.0182684
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0181394
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0175844
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0175196
ANKRD28 ankyrin repeat domain 28 -0.0174553
TSC22D2 TSC22 domain family, member 2 -0.0174361