olaparib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description olaparib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the olaparib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 0.0860527
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0851505
MBNL2 muscleblind-like splicing regulator 2 0.0689796
PHF3 PHD finger protein 3 0.0667319
DSCAM Down syndrome cell adhesion molecule 0.0551992
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0548282
IFNGR1 interferon gamma receptor 1 0.051659
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0508488
RUNX1 runt-related transcription factor 1 0.0498485
BCLAF1 BCL2-associated transcription factor 1 0.0491693
PRELID2 PRELI domain containing 2 0.0470152
BICRAL BICRA like chromatin remodeling complex associated protein 0.0457377
ASPH aspartate beta-hydroxylase 0.0443164
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0438158
RNF43 ring finger protein 43 0.0422537
RAD51B RAD51 paralog B 0.0411917
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0409456
TXNIP thioredoxin interacting protein 0.0407544
N4BP2L2 NEDD4 binding protein 2-like 2 0.0402455
NRIP1 nuclear receptor interacting protein 1 0.0400125
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0396338
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0372292
MEIS2 Meis homeobox 2 0.0362382
DIAPH3 diaphanous-related formin 3 0.0355781
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.035484
NCKAP5 NCK-associated protein 5 0.0350236
UBAC2 UBA domain containing 2 0.0346038
FNDC3A fibronectin type III domain containing 3A 0.0337738
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0337288
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0333515
TRIO trio Rho guanine nucleotide exchange factor 0.0331982
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0321782
AHI1 Abelson helper integration site 1 0.0318578
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0314815
EHF ets homologous factor 0.0308227
MCTP2 multiple C2 domains, transmembrane 2 0.0307989
ZMYM2 zinc finger, MYM-type 2 0.0306576
AOPEP aminopeptidase O (putative) 0.0301275
SEC24D SEC24 family member D 0.0296638
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0286977
RBM26 RNA binding motif protein 26 0.0285851
RBM39 RNA binding motif protein 39 0.0280024
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0278853
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0277895
PTBP3 polypyrimidine tract binding protein 3 0.0274075
ARHGAP32 Rho GTPase activating protein 32 0.0270952
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0270283
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0269406
GOLGB1 golgin B1 0.0269396
CD46 CD46 molecule, complement regulatory protein 0.0267435
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0260779
OGA O-GlcNAcase 0.0256066
COG6 component of oligomeric golgi complex 6 0.0248144
BRCA2 breast cancer 2, early onset 0.0247052
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0246496
MBD5 methyl-CpG binding domain protein 5 0.0242078
SAMD12 sterile alpha motif domain containing 12 0.0241266
TM9SF2 transmembrane 9 superfamily member 2 0.02409
XRN1 5'-3' exoribonuclease 1 0.0239179
MYH9 myosin, heavy chain 9, non-muscle 0.0237991
ATXN1 ataxin 1 0.023693
SBF2 SET binding factor 2 0.0236757
PATJ PATJ crumbs cell polarity complex component 0.0236202
USPL1 ubiquitin specific peptidase like 1 0.0235879
AFF1 AF4/FMR2 family, member 1 0.0235302
PDE4D phosphodiesterase 4D, cAMP-specific 0.0232915
PTEN phosphatase and tensin homolog 0.023262
PDIA4 protein disulfide isomerase family A, member 4 0.023147
SAMD4A sterile alpha motif domain containing 4A 0.0230791
TUBGCP3 tubulin, gamma complex associated protein 3 0.0228545
RHOBTB3 Rho-related BTB domain containing 3 0.022834
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0226916
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0225231
ALPK1 alpha-kinase 1 0.0221921
XPO1 exportin 1 0.0221306
FAT1 FAT atypical cadherin 1 0.02207
SUCO SUN domain containing ossification factor 0.0216931
GRK3 G protein-coupled receptor kinase 3 0.0216151
STK24 serine/threonine kinase 24 0.021314
PDS5B PDS5 cohesin associated factor B 0.0212988
ARRDC3 arrestin domain containing 3 0.0211854
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0211407
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0210374
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0209226
TBC1D5 TBC1 domain family, member 5 0.0207799
OARD1 O-acyl-ADP-ribose deacylase 1 0.0206698
ZDHHC20 zinc finger, DHHC-type containing 20 0.0204872
MKI67 marker of proliferation Ki-67 0.0203854
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.020372
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0202708
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0200923
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0200553
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.019876
BRWD3 bromodomain and WD repeat domain containing 3 0.0198229
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0197725
METTL15 methyltransferase like 15 0.0194361
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0194028
AHNAK AHNAK nucleoprotein 0.0193924
IL20RA interleukin 20 receptor, alpha 0.0193817
KIF16B kinesin family member 16B 0.0191435

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.169633
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121336
TPT1 tumor protein, translationally-controlled 1 -0.105942
LCN2 lipocalin 2 -0.0970465
ANXA2 annexin A2 -0.0883115
B2M beta-2-microglobulin -0.0878818
IFI6 interferon, alpha-inducible protein 6 -0.0831778
FTL ferritin, light polypeptide -0.0804758
HLA-B major histocompatibility complex, class I, B -0.078743
RAB7A RAB7A, member RAS oncogene family -0.0786656
C6ORF132 chromosome 6 open reading frame 132 -0.0783056
LMO7 LIM domain 7 -0.072304
MYO1E myosin IE -0.0684917
LOC102724023 ES1 protein homolog, mitochondrial -0.0683725
RNF213 ring finger protein 213 -0.0680355
ACTG1 actin gamma 1 -0.0650946
VCL vinculin -0.0646342
SQSTM1 sequestosome 1 -0.0592945
PERP PERP, TP53 apoptosis effector -0.0588788
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0586925
LYZ lysozyme -0.056206
FTH1 ferritin, heavy polypeptide 1 -0.0562003
PKM pyruvate kinase, muscle -0.0555022
JUN jun proto-oncogene -0.0553726
SP100 SP100 nuclear antigen -0.0545633
INTS6 integrator complex subunit 6 -0.0544339
TJP1 tight junction protein 1 -0.0542411
RIGI RNA sensor RIG-I -0.0504225
POTEF POTE ankyrin domain family, member F -0.050243
MACC1 metastasis associated in colon cancer 1 -0.0495037
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0490913
XAF1 XIAP associated factor 1 -0.0482848
LOC112694756 uncharaterized LOC112694756 -0.0481554
BAIAP2L1 BAI1-associated protein 2-like 1 -0.045193
MX2 MX dynamin-like GTPase 2 -0.0450771
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0440415
IFI27 interferon, alpha-inducible protein 27 -0.0429274
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0423509
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0421975
AREG amphiregulin -0.0417577
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0408584
FOS FBJ murine osteosarcoma viral oncogene homolog -0.040686
RPL23 ribosomal protein L23 -0.0393228
ERBIN erbb2 interacting protein -0.0391418
MCTP1 multiple C2 domains, transmembrane 1 -0.0390319
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0385669
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0383166
RPL35A ribosomal protein L35a -0.0376058
SLC38A1 solute carrier family 38, member 1 -0.0371675
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0367912
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0352828
TMC5 transmembrane channel-like 5 -0.0352696
EIF1 eukaryotic translation initiation factor 1 -0.0348826
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0348473
AKAP13 A kinase (PRKA) anchor protein 13 -0.0347987
RPS24 ribosomal protein S24 -0.0332439
RPL7L1 ribosomal protein L7-like 1 -0.0332234
IFITM3 interferon induced transmembrane protein 3 -0.0331607
EZR ezrin -0.0325073
GCLC glutamate-cysteine ligase, catalytic subunit -0.0322763
TM4SF19 transmembrane 4 L six family member 19 -0.0321894
MT2A metallothionein 2A -0.0321346
IGFBP3 insulin-like growth factor binding protein 3 -0.0319876
KRT19 keratin 19, type I -0.0318123
SPAG9 sperm associated antigen 9 -0.0317952
HLA-A major histocompatibility complex, class I, A -0.0316503
S100P S100 calcium binding protein P -0.0315617
PTMA prothymosin, alpha -0.0306464
H1-0 H1.0 linker histone -0.0303598
MUC20 mucin 20, cell surface associated -0.0300768
TM4SF1 transmembrane 4 L six family member 1 -0.0299812
TMSB10 thymosin beta 10 -0.0298351
HLA-E major histocompatibility complex, class I, E -0.0297458
DDIT3 DNA-damage-inducible transcript 3 -0.0294364
S100A10 S100 calcium binding protein A10 -0.0293216
SIPA1L2 signal-induced proliferation-associated 1 like 2 -0.0292024
UBAP2 ubiquitin associated protein 2 -0.0291791
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0290994
S100A11 S100 calcium binding protein A11 -0.0289481
CLDN4 claudin 4 -0.028524
CSTB cystatin B (stefin B) -0.028468
PLSCR1 phospholipid scramblase 1 -0.0282876
CTSD cathepsin D -0.0282595
RPL34 ribosomal protein L34 -0.0276996
SLC38A2 solute carrier family 38, member 2 -0.0276204
CST3 cystatin C -0.027366
BCL2L1 BCL2-like 1 -0.0269505
KLF6 Kruppel-like factor 6 -0.026783
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.026224
VDAC1 voltage-dependent anion channel 1 -0.0261405
RPL31 ribosomal protein L31 -0.0258455
RPL11 ribosomal protein L11 -0.0258014
RPL37A ribosomal protein L37a -0.0255626
IER3 immediate early response 3 -0.025382
RPLP1 ribosomal protein, large, P1 -0.0252277
EFNB2 ephrin-B2 -0.0250662
RPS8 ribosomal protein S8 -0.0247263
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0245257
HLA-C major histocompatibility complex, class I, C -0.024457
TRIB1 tribbles pseudokinase 1 -0.0243195