| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | olaparib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the olaparib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.102156 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.101359 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.071764 |
| ARRDC3 | arrestin domain containing 3 | 0.0694283 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0685885 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0623332 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0614792 |
| SMAD3 | SMAD family member 3 | 0.052854 |
| PTMA | prothymosin, alpha | 0.0519113 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0439512 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0429478 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0427953 |
| FBXO32 | F-box protein 32 | 0.0416082 |
| LOXL2 | lysyl oxidase-like 2 | 0.0411543 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0388053 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0368657 |
| CENPF | centromere protein F, 350/400kDa | 0.0357103 |
| CADM1 | cell adhesion molecule 1 | 0.0345633 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0345011 |
| COL1A2 | collagen, type I, alpha 2 | 0.0333647 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0315702 |
| ZNF292 | zinc finger protein 292 | 0.0315466 |
| UBC | ubiquitin C | 0.0313666 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0311151 |
| TPM4 | tropomyosin 4 | 0.0310998 |
| RIGI | RNA sensor RIG-I | 0.0307393 |
| COL1A1 | collagen, type I, alpha 1 | 0.0301355 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0298446 |
| MX2 | MX dynamin-like GTPase 2 | 0.0298094 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0295261 |
| RNF220 | ring finger protein 220 | 0.029427 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0287026 |
| B2M | beta-2-microglobulin | 0.0284851 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0276388 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0275707 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0269899 |
| YBX1 | Y box binding protein 1 | 0.0268688 |
| OGA | O-GlcNAcase | 0.0266043 |
| JAK2 | Janus kinase 2 | 0.0255182 |
| RPS6 | ribosomal protein S6 | 0.025302 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0252899 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0249607 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0246912 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0245617 |
| PRELID2 | PRELI domain containing 2 | 0.024512 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0233012 |
| RARB | retinoic acid receptor, beta | 0.0232786 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.023096 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0228442 |
| ANXA2 | annexin A2 | 0.0226879 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0225673 |
| CFB | complement factor B | 0.0225351 |
| CD44 | CD44 molecule (Indian blood group) | 0.0224897 |
| HAS2 | hyaluronan synthase 2 | 0.0219711 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.021858 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0217554 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0212502 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0206228 |
| MKI67 | marker of proliferation Ki-67 | 0.0205969 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0204345 |
| RNF145 | ring finger protein 145 | 0.0204314 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0203791 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0203031 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0202882 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0202187 |
| POSTN | periostin, osteoblast specific factor | 0.0201218 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0201098 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0197695 |
| LDHA | lactate dehydrogenase A | 0.0197286 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0187066 |
| COL3A1 | collagen, type III, alpha 1 | 0.0183407 |
| SETD5 | SET domain containing 5 | 0.0178726 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0178535 |
| AOPEP | aminopeptidase O (putative) | 0.0178421 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.0176592 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0176364 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0175415 |
| KIAA1217 | KIAA1217 | 0.0174308 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.017401 |
| PLSCR1 | phospholipid scramblase 1 | 0.0171259 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0169819 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0168449 |
| SDC4 | syndecan 4 | 0.016611 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0162557 |
| OPTN | optineurin | 0.0161475 |
| NREP | neuronal regeneration related protein | 0.0160917 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0160708 |
| IFI44L | interferon-induced protein 44-like | 0.0160244 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0157044 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0155935 |
| SPAG9 | sperm associated antigen 9 | 0.0155153 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0153657 |
| ADM | adrenomedullin | 0.0153468 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0152798 |
| HMGB2 | high mobility group box 2 | 0.0150959 |
| SBF2 | SET binding factor 2 | 0.0150941 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0150178 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0149542 |
| PHIP | pleckstrin homology domain interacting protein | 0.0148179 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0147807 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH13 | cadherin 13 | -0.2916 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.279418 |
| NDRG1 | N-myc downstream regulated 1 | -0.147951 |
| HMGA2 | high mobility group AT-hook 2 | -0.115786 |
| COL6A3 | collagen, type VI, alpha 3 | -0.11545 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0952546 |
| COL5A1 | collagen, type V, alpha 1 | -0.0857453 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0829256 |
| STC1 | stanniocalcin 1 | -0.0817277 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0726272 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0715049 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0694736 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0694002 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0668721 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0650669 |
| ASPH | aspartate beta-hydroxylase | -0.0640089 |
| FBN1 | fibrillin 1 | -0.0633263 |
| PDE10A | phosphodiesterase 10A | -0.062898 |
| EFNA5 | ephrin-A5 | -0.0624555 |
| FN1 | fibronectin 1 | -0.0613043 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0568548 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0531846 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0528835 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0524992 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0506548 |
| LOX | lysyl oxidase | -0.0501998 |
| NAV1 | neuron navigator 1 | -0.0471852 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0466259 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.045906 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0440757 |
| GLIS3 | GLIS family zinc finger 3 | -0.0440019 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0433427 |
| MYO10 | myosin X | -0.0427761 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0414831 |
| RUNX1 | runt-related transcription factor 1 | -0.0410353 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0400087 |
| CLMP | CXADR-like membrane protein | -0.0399149 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0392773 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0389885 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0387938 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0386755 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0377965 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.037567 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0366948 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0364895 |
| FMNL2 | formin-like 2 | -0.0363684 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0357631 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0353217 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0352206 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0351504 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.034844 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0346357 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0329429 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0322045 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0319157 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0315231 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0311137 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0306111 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0299355 |
| EGFR | epidermal growth factor receptor | -0.0296705 |
| MTSS1 | metastasis suppressor 1 | -0.0296047 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0292984 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0289898 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0284342 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0281319 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0278644 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0278024 |
| EGR1 | early growth response 1 | -0.0274694 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0274229 |
| PLEC | plectin | -0.0264587 |
| ACTG1 | actin gamma 1 | -0.0264128 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0258798 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0256674 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0255804 |
| NEK10 | NIMA-related kinase 10 | -0.0254664 |
| NOTCH2 | notch 2 | -0.0253963 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0250868 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0248094 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0247501 |
| ACTN1 | actinin, alpha 1 | -0.024278 |
| ECE1 | endothelin converting enzyme 1 | -0.0242312 |
| NAV2 | neuron navigator 2 | -0.0242293 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0241874 |
| TMEM165 | transmembrane protein 165 | -0.0241625 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.024066 |
| MTDH | metadherin | -0.0239206 |
| HM13 | histocompatibility (minor) 13 | -0.0236528 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0235689 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0234858 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0234302 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0232883 |
| EPHB1 | EPH receptor B1 | -0.0231644 |
| PTK2 | protein tyrosine kinase 2 | -0.0230999 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0228956 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0227035 |
| GOLGB1 | golgin B1 | -0.021932 |
| ANO10 | anoctamin 10 | -0.0216269 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0214202 |
| VCAN | versican | -0.0213123 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0212409 |
