olaparib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description olaparib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the olaparib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SVIL supervillin 0.09039
MT2A metallothionein 2A 0.0834572
TPT1 tumor protein, translationally-controlled 1 0.071742
RPL11 ribosomal protein L11 0.0554939
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0553386
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0547594
TMSB10 thymosin beta 10 0.0546889
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0525187
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0483749
FRMD5 FERM domain containing 5 0.0475009
ATXN1 ataxin 1 0.0468153
SAMD4A sterile alpha motif domain containing 4A 0.0456749
ASPH aspartate beta-hydroxylase 0.044167
RPL35A ribosomal protein L35a 0.0441465
ISG15 ISG15 ubiquitin-like modifier 0.044006
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0397951
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.03864
TRIO trio Rho guanine nucleotide exchange factor 0.0366785
RPS27A ribosomal protein S27a 0.0363062
RPL37A ribosomal protein L37a 0.0355778
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.034163
TM4SF1 transmembrane 4 L six family member 1 0.0339418
DSPP dentin sialophosphoprotein 0.032231
TBC1D22A TBC1 domain family, member 22A 0.0322204
EXT1 exostosin glycosyltransferase 1 0.0319607
KIAA1217 KIAA1217 0.0315509
PDE4D phosphodiesterase 4D, cAMP-specific 0.0315137
GRB10 growth factor receptor-bound protein 10 0.0312933
INTS6 integrator complex subunit 6 0.0306582
IGFBP1 insulin-like growth factor binding protein 1 0.0301666
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0292343
ACTG1 actin gamma 1 0.029039
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0289112
RPS17 ribosomal protein S17 0.0281595
PTMA prothymosin, alpha 0.0267082
VIM vimentin 0.026459
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.026317
PDLIM5 PDZ and LIM domain 5 0.0261745
IQSEC1 IQ motif and Sec7 domain 1 0.025225
MCL1 myeloid cell leukemia 1 0.0251596
RUNX1 runt-related transcription factor 1 0.0247991
RPLP1 ribosomal protein, large, P1 0.0245778
IFIH1 interferon induced with helicase C domain 1 0.0244763
KYNU kynureninase 0.0243955
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0243295
MYH9 myosin, heavy chain 9, non-muscle 0.0238165
AKAP12 A kinase (PRKA) anchor protein 12 0.0232633
RPS29 ribosomal protein S29 0.02296
ITGB5 integrin, beta 5 0.0226821
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0226371
ABTB3 ankyrin repeat and BTB domain containing 3 0.0224705
MRTFA myocardin related transcription factor A 0.0224178
RPS19 ribosomal protein S19 0.0224152
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0220182
ANKRD11 ankyrin repeat domain 11 0.021687
RPL23 ribosomal protein L23 0.0216782
RPL31 ribosomal protein L31 0.0213795
TIMP2 TIMP metallopeptidase inhibitor 2 0.0208814
RPLP2 ribosomal protein, large, P2 0.0204916
RPS27 ribosomal protein S27 0.0204704
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0203715
FAT1 FAT atypical cadherin 1 0.0203357
RIGI RNA sensor RIG-I 0.0202916
RPL34 ribosomal protein L34 0.0201592
RPL36A ribosomal protein L36a 0.0201552
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0201513
KDM3A lysine (K)-specific demethylase 3A 0.0200687
IFI6 interferon, alpha-inducible protein 6 0.0199956
ZFAND3 zinc finger, AN1-type domain 3 0.0197783
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0197463
RPS13 ribosomal protein S13 0.0196343
NDRG1 N-myc downstream regulated 1 0.0191914
LIMS1 LIM and senescent cell antigen-like domains 1 0.0191867
KAZN kazrin, periplakin interacting protein 0.019164
KRT8 keratin 8, type II 0.019118
EXOC4 exocyst complex component 4 0.0190764
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0189753
SBF2 SET binding factor 2 0.0188804
DNAH17 dynein, axonemal, heavy chain 17 0.018822
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.0188071
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0185003
CAPRIN2 caprin family member 2 0.0184764
EZR ezrin 0.0183244
ZSWIM5 zinc finger, SWIM-type containing 5 0.018161
TMF1 TATA element modulatory factor 1 0.0181598
RPS8 ribosomal protein S8 0.0181297
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0181021
MAP2K1 mitogen-activated protein kinase kinase 1 0.0179973
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0179841
ENAH enabled homolog (Drosophila) 0.0179105
SORBS1 sorbin and SH3 domain containing 1 0.0177112
N4BP1 NEDD4 binding protein 1 0.0177075
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0176904
SMYD3 SET and MYND domain containing 3 0.0176205
SUB1 SUB1 homolog (S. cerevisiae) 0.0176109
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0175881
SP100 SP100 nuclear antigen 0.0175725
LRMDA leucine rich melanocyte differentiation associated 0.0175395
FERMT2 fermitin family member 2 0.0175344
DUSP16 dual specificity phosphatase 16 0.017467

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.362927
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.300832
C3 complement component 3 -0.208835
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.169837
FN1 fibronectin 1 -0.130253
ERRFI1 ERBB receptor feedback inhibitor 1 -0.116792
FBF1 Fas (TNFRSF6) binding factor 1 -0.106267
APOB apolipoprotein B -0.0958644
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0867334
AHSG alpha-2-HS-glycoprotein -0.0857341
TMEM123 transmembrane protein 123 -0.0834976
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0794142
PEG3 paternally expressed 3 -0.0706562
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.068395
TF transferrin -0.0670015
GPC3 glypican 3 -0.0634091
FNDC3B fibronectin type III domain containing 3B -0.0574558
A2M alpha-2-macroglobulin -0.0571769
PEG10 paternally expressed 10 -0.0570344
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0569089
LYZ lysozyme -0.0552362
PLIN2 perilipin 2 -0.0523276
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0522986
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0509949
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0509477
PTPRM protein tyrosine phosphatase, receptor type, M -0.0505858
EML4 echinoderm microtubule associated protein like 4 -0.0475138
ENO1 enolase 1, (alpha) -0.0475036
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0474415
PCBP2 poly(rC) binding protein 2 -0.046044
SESTD1 SEC14 and spectrin domains 1 -0.0452924
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0450843
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0449115
CPE carboxypeptidase E -0.0442257
DLC1 DLC1 Rho GTPase activating protein -0.0432051
CANX calnexin -0.0421308
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0415068
ITGA1 integrin, alpha 1 -0.0413278
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0395381
TRIM26 tripartite motif containing 26 -0.0392701
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0390758
QKI QKI, KH domain containing, RNA binding -0.0381008
SLC38A2 solute carrier family 38, member 2 -0.0374066
GNAS GNAS complex locus -0.0370866
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0357857
ELL2 elongation factor, RNA polymerase II, 2 -0.0357613
LDHA lactate dehydrogenase A -0.035144
STAU1 staufen double-stranded RNA binding protein 1 -0.0334479
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0325953
ADGRG6 adhesion G protein-coupled receptor G6 -0.0313817
PDIA3 protein disulfide isomerase family A, member 3 -0.0313721
EEF2 eukaryotic translation elongation factor 2 -0.0312543
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0309599
PTBP3 polypyrimidine tract binding protein 3 -0.0302842
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0298911
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0296329
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0291684
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0291203
CP ceruloplasmin (ferroxidase) -0.0288768
MARCKS myristoylated alanine-rich protein kinase C substrate -0.028316
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0276957
RPLP0 ribosomal protein, large, P0 -0.0274394
WDR45B WD repeat domain 45B -0.0272937
SQSTM1 sequestosome 1 -0.0265424
CFB complement factor B -0.0264923
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.026347
SELENOP selenoprotein P -0.0252762
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0252248
GMDS GDP-mannose 4,6-dehydratase -0.0245152
MTUS1 microtubule associated tumor suppressor 1 -0.0238086
INSIG2 insulin induced gene 2 -0.0235108
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0231908
LMAN1 lectin, mannose-binding, 1 -0.0231719
EPAS1 endothelial PAS domain protein 1 -0.0231439
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0230025
RBM39 RNA binding motif protein 39 -0.0229725
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0229056
RBM25 RNA binding motif protein 25 -0.0225999
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0225437
WAC WW domain containing adaptor with coiled-coil -0.0225221
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.022439
RSRC2 arginine/serine-rich coiled-coil 2 -0.0223437
CYTH1 cytohesin 1 -0.022157
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0218224
ITGAV integrin, alpha V -0.0217421
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.021725
LOX lysyl oxidase -0.0216849
TMEM45B transmembrane protein 45B -0.0213105
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0211688
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0209954
GOLGA4 golgin A4 -0.0209731
STK17A serine/threonine kinase 17a -0.0209109
SPAG9 sperm associated antigen 9 -0.0208682
ARHGAP12 Rho GTPase activating protein 12 -0.0207429
VDAC1 voltage-dependent anion channel 1 -0.0206682
FNBP1L formin binding protein 1-like -0.0206125
RYBP RING1 and YY1 binding protein -0.0204952
RLF rearranged L-myc fusion -0.0204126
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0203984
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0203736