olaparib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description olaparib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the olaparib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.167811
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.124073
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.100052
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0989713
DST dystonin 0.0900498
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0872576
CENPF centromere protein F, 350/400kDa 0.0670877
ZNF292 zinc finger protein 292 0.064672
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0631076
RBM39 RNA binding motif protein 39 0.0627954
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0615501
OGA O-GlcNAcase 0.0610233
KDM3A lysine (K)-specific demethylase 3A 0.0572891
DLG1 discs, large homolog 1 (Drosophila) 0.0566771
RAI1 retinoic acid induced 1 0.0554876
MT2A metallothionein 2A 0.0541682
EZR ezrin 0.0535764
XPO1 exportin 1 0.0525406
TRIO trio Rho guanine nucleotide exchange factor 0.052384
FNIP1 folliculin interacting protein 1 0.0505207
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0474435
ANKRD11 ankyrin repeat domain 11 0.0464672
GOLGA4 golgin A4 0.0463004
WSB1 WD repeat and SOCS box containing 1 0.0459984
AHNAK AHNAK nucleoprotein 0.0453258
GARS1 glycyl-tRNA synthetase 1 0.0444754
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0443445
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0443001
TRA2A transformer 2 alpha homolog (Drosophila) 0.0435452
MKI67 marker of proliferation Ki-67 0.0434789
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0434159
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.042972
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0427925
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0423429
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0418635
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.041234
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0412151
KMT2C lysine (K)-specific methyltransferase 2C 0.0411024
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0408109
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0399782
ERRFI1 ERBB receptor feedback inhibitor 1 0.0387965
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0386018
SRPK2 SRSF protein kinase 2 0.0381115
NAMPT nicotinamide phosphoribosyltransferase 0.0371811
EFNA5 ephrin-A5 0.0366301
SPAG9 sperm associated antigen 9 0.0365719
CKAP5 cytoskeleton associated protein 5 0.0364786
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0364692
PUM2 pumilio RNA-binding family member 2 0.0362403
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0360683
CDK19 cyclin-dependent kinase 19 0.0359809
YEATS2 YEATS domain containing 2 0.0354441
TMSB4X thymosin beta 4, X-linked 0.0350835
MATR3 matrin 3 0.0349949
ANLN anillin, actin binding protein 0.0346599
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0345509
SMYD3 SET and MYND domain containing 3 0.0343013
PGK1 phosphoglycerate kinase 1 0.0341318
CANX calnexin 0.0336577
ARRDC3 arrestin domain containing 3 0.0330507
ANXA1 annexin A1 0.0324645
MARCHF6 membrane associated ring-CH-type finger 6 0.0323136
EXOC4 exocyst complex component 4 0.0321093
GIGYF2 GRB10 interacting GYF protein 2 0.0319459
PNISR PNN-interacting serine/arginine-rich protein 0.0318376
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.03163
SETD5 SET domain containing 5 0.0313247
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0309393
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0308358
PHIP pleckstrin homology domain interacting protein 0.0305861
SEPTIN7 septin 7 0.030562
RPL37A ribosomal protein L37a 0.0305498
KIF5B kinesin family member 5B 0.030412
PTBP2 polypyrimidine tract binding protein 2 0.0302253
SMC4 structural maintenance of chromosomes 4 0.0299002
RNF145 ring finger protein 145 0.029846
HMGB2 high mobility group box 2 0.0296261
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0294655
ANKRD36 ankyrin repeat domain 36 0.0293275
PRRC2C proline-rich coiled-coil 2C 0.0293076
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0291603
CAMTA1 calmodulin binding transcription activator 1 0.0291212
ZFAND3 zinc finger, AN1-type domain 3 0.0290242
CFDP1 craniofacial development protein 1 0.0289947
TPX2 TPX2, microtubule-associated 0.028891
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0287722
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0286803
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0285044
RTN4 reticulon 4 0.0283866
STAG2 stromal antigen 2 0.0283476
BRWD1 bromodomain and WD repeat domain containing 1 0.0283003
RPS8 ribosomal protein S8 0.0282969
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0278539
BIRC2 baculoviral IAP repeat containing 2 0.0277839
SBF2 SET binding factor 2 0.0276244
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0275701
QKI QKI, KH domain containing, RNA binding 0.0273953
CALR calreticulin 0.0273589
ZNF148 zinc finger protein 148 0.0273208
FXR1 fragile X mental retardation, autosomal homolog 1 0.0272833

decreased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 -0.121473
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104158
EGR1 early growth response 1 -0.0917547
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0909232
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0784001
POTEF POTE ankyrin domain family, member F -0.0606675
HMGA1 high mobility group AT-hook 1 -0.0585751
TP63 tumor protein p63 -0.057895
FTH1 ferritin, heavy polypeptide 1 -0.0565687
VIM vimentin -0.0548085
CD44 CD44 molecule (Indian blood group) -0.050422
PDE10A phosphodiesterase 10A -0.049898
WWTR1 WW domain containing transcription regulator 1 -0.0443992
CMIP c-Maf inducing protein -0.0431851
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0427913
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0417922
DNER delta/notch-like EGF repeat containing -0.0401644
RUNX1 runt-related transcription factor 1 -0.0396672
TM4SF1 transmembrane 4 L six family member 1 -0.038996
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0386222
CAPRIN2 caprin family member 2 -0.0379617
LOC112694756 uncharaterized LOC112694756 -0.0372048
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0362658
ZBTB38 zinc finger and BTB domain containing 38 -0.0357273
TGM2 transglutaminase 2 -0.0354351
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0337966
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0335595
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0333203
RAB7A RAB7A, member RAS oncogene family -0.0319283
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0311561
PODXL podocalyxin-like -0.0308814
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0305684
RAP2B RAP2B, member of RAS oncogene family -0.0297558
PYGL phosphorylase, glycogen, liver -0.0297104
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0288862
ACTG1 actin gamma 1 -0.0288632
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0284201
TSC22D1 TSC22 domain family, member 1 -0.0273706
NEK10 NIMA-related kinase 10 -0.0273109
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0272616
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.02661
NPAS2 neuronal PAS domain protein 2 -0.0259103
SDCCAG8 serologically defined colon cancer antigen 8 -0.0254823
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0253616
THSD4 thrombospondin, type I, domain containing 4 -0.0247649
RAB27B RAB27B, member RAS oncogene family -0.0245296
SPRY4 sprouty homolog 4 (Drosophila) -0.0238792
PLSCR1 phospholipid scramblase 1 -0.0237016
EEF2 eukaryotic translation elongation factor 2 -0.0235437
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0234278
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0232877
PCDH1 protocadherin 1 -0.0228973
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0227633
HOMER1 homer scaffolding protein 1 -0.0221674
ZSWIM6 zinc finger, SWIM-type containing 6 -0.022088
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0218732
LOC102724023 ES1 protein homolog, mitochondrial -0.0217614
CFAP299 cilia and flagella associated protein 299 -0.0217572
NT5E 5'-nucleotidase, ecto (CD73) -0.0216331
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0214382
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0210511
HSPG2 heparan sulfate proteoglycan 2 -0.0206672
JUN jun proto-oncogene -0.0204624
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0203934
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.019928
CCDC190 coiled-coil domain containing 190 -0.0198074
SGMS2 sphingomyelin synthase 2 -0.0197642
CADM2 cell adhesion molecule 2 -0.0195224
TAPBP TAP binding protein (tapasin) -0.0195222
SGK1 serum/glucocorticoid regulated kinase 1 -0.0193238
ATN1 atrophin 1 -0.0192681
SOX9 SRY (sex determining region Y)-box 9 -0.0191092
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0188077
ECE1 endothelin converting enzyme 1 -0.0187499
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0187125
CAPN2 calpain 2, (m/II) large subunit -0.0186126
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0183437
NTSR1 neurotensin receptor 1 (high affinity) -0.0179793
UBA1 ubiquitin-like modifier activating enzyme 1 -0.0177135
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0176541
PRRC2B proline-rich coiled-coil 2B -0.0168635
WDR27 WD repeat domain 27 -0.0165393
AGRN agrin -0.0159291
MYADM myeloid-associated differentiation marker -0.0158982
FERMT1 fermitin family member 1 -0.015726
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0154193
CDCP1 CUB domain containing protein 1 -0.0153757
ITGB4 integrin, beta 4 -0.0152251
CD68 CD68 molecule -0.0151784
BICD1 bicaudal D homolog 1 (Drosophila) -0.0151559
SDK1 sidekick cell adhesion molecule 1 -0.0148725
FOSL1 FOS-like antigen 1 -0.0148536
SP100 SP100 nuclear antigen -0.0146013
RGS4 regulator of G-protein signaling 4 -0.0144828
ANTXR2 anthrax toxin receptor 2 -0.0142934
HBEGF heparin-binding EGF-like growth factor -0.0141086
ARHGAP5 Rho GTPase activating protein 5 -0.0140995
OSMR oncostatin M receptor -0.0140845
ERCC1 excision repair cross-complementation group 1 -0.0139594
INTS6 integrator complex subunit 6 -0.0138852