| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | olaparib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the olaparib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.179206 |
| TXNRD1 | thioredoxin reductase 1 | 0.0984916 |
| GRAMD1B | GRAM domain containing 1B | 0.0948481 |
| FGB | fibrinogen beta chain | 0.0686216 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.050296 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0427026 |
| WDR43 | WD repeat domain 43 | 0.042525 |
| TPM3 | tropomyosin 3 | 0.036811 |
| YBX3 | Y box binding protein 3 | 0.0351683 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0349647 |
| ASPH | aspartate beta-hydroxylase | 0.0317902 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0316865 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0316188 |
| USP3 | ubiquitin specific peptidase 3 | 0.02995 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0293448 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0288488 |
| CCNL1 | cyclin L1 | 0.0280465 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0278844 |
| AHR | aryl hydrocarbon receptor | 0.0272509 |
| FGA | fibrinogen alpha chain | 0.0268907 |
| FAM168A | family with sequence similarity 168, member A | 0.0266902 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0256622 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0255515 |
| RTN4 | reticulon 4 | 0.0243231 |
| MKI67 | marker of proliferation Ki-67 | 0.0242703 |
| MATR3 | matrin 3 | 0.0239747 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0238908 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0233214 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0227403 |
| ECT2 | epithelial cell transforming 2 | 0.0227046 |
| NTN4 | netrin 4 | 0.022373 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0222995 |
| YBX1 | Y box binding protein 1 | 0.0219558 |
| ZNF292 | zinc finger protein 292 | 0.0219331 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0216369 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0211977 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0209865 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.020866 |
| RBM8A | RNA binding motif protein 8A | 0.0207382 |
| TPD52 | tumor protein D52 | 0.0206039 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0204476 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.020094 |
| FGG | fibrinogen gamma chain | 0.0197389 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0195716 |
| CENPF | centromere protein F, 350/400kDa | 0.0195465 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0191415 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0190421 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0189566 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0187749 |
| YME1L1 | YME1-like 1 ATPase | 0.0180939 |
| HDAC9 | histone deacetylase 9 | 0.0180146 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.0179351 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0179306 |
| JAK1 | Janus kinase 1 | 0.0178772 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0178214 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0178087 |
| WBP11 | WW domain binding protein 11 | 0.0177899 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0176355 |
| EFNA5 | ephrin-A5 | 0.0175007 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0172344 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0170649 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0168658 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0168345 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0167057 |
| RBM39 | RNA binding motif protein 39 | 0.0166778 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0166427 |
| TPX2 | TPX2, microtubule-associated | 0.0164516 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0164512 |
| CHN1 | chimerin 1 | 0.0163372 |
| RHEB | Ras homolog enriched in brain | 0.0162398 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0161827 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0161608 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0160169 |
| PDE8A | phosphodiesterase 8A | 0.015925 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0158292 |
| NUP58 | nucleoporin 58 | 0.015765 |
| ENAH | enabled homolog (Drosophila) | 0.0156939 |
| RNF145 | ring finger protein 145 | 0.015652 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0153171 |
| RPS7 | ribosomal protein S7 | 0.015111 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0149215 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0148665 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0147488 |
| HBS1L | HBS1-like translational GTPase | 0.0147394 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0146421 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0145762 |
| TFG | TRK-fused gene | 0.0144741 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0143382 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0143037 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0142404 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0141847 |
| ANLN | anillin, actin binding protein | 0.0139053 |
| KIF23 | kinesin family member 23 | 0.0138882 |
| SP3 | Sp3 transcription factor | 0.0138869 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0137654 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0136445 |
| POU2F1 | POU class 2 homeobox 1 | 0.0136004 |
| RPL4 | ribosomal protein L4 | 0.0135665 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0135556 |
| RRM2 | ribonucleotide reductase M2 | 0.0134904 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.359824 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.188706 |
| TMSB10 | thymosin beta 10 | -0.141525 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.120399 |
| FTL | ferritin, light polypeptide | -0.118539 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.107316 |
| VIM | vimentin | -0.100671 |
| ACTG1 | actin gamma 1 | -0.0798637 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0778599 |
| IGF2 | insulin-like growth factor 2 | -0.0744296 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0727564 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0721074 |
| IER3 | immediate early response 3 | -0.0634611 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0597553 |
| CMIP | c-Maf inducing protein | -0.0562903 |
| S100A6 | S100 calcium binding protein A6 | -0.0538986 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.05115 |
| RPLP1 | ribosomal protein, large, P1 | -0.0486637 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0486034 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0475627 |
| RPL23 | ribosomal protein L23 | -0.0474165 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.046173 |
| FLNB | filamin B, beta | -0.0444571 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.042971 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0419439 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0401909 |
| EGFR | epidermal growth factor receptor | -0.040044 |
| POTEF | POTE ankyrin domain family, member F | -0.0393908 |
| EGR1 | early growth response 1 | -0.0386114 |
| STC1 | stanniocalcin 1 | -0.0375886 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0374284 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0355263 |
| PFN1 | profilin 1 | -0.035506 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0344062 |
| PYGL | phosphorylase, glycogen, liver | -0.0339353 |
| HLA-B | major histocompatibility complex, class I, B | -0.0337812 |
| RPL35A | ribosomal protein L35a | -0.0337624 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0334369 |
| FMNL2 | formin-like 2 | -0.0328656 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0322226 |
| PKM | pyruvate kinase, muscle | -0.0307712 |
| RAB7A | RAB7A, member RAS oncogene family | -0.030444 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0292836 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0291746 |
| MORF4L2 | mortality factor 4 like 2 | -0.0288215 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0288122 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0282207 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0281727 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0278774 |
| S100A10 | S100 calcium binding protein A10 | -0.0274479 |
| ACTN1 | actinin, alpha 1 | -0.0271874 |
| RPL19 | ribosomal protein L19 | -0.0267869 |
| FLNA | filamin A, alpha | -0.0265437 |
| HMGA1 | high mobility group AT-hook 1 | -0.0259288 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0255696 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0253056 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0249604 |
| RPS21 | ribosomal protein S21 | -0.024703 |
| S100A11 | S100 calcium binding protein A11 | -0.0246051 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0244088 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0242312 |
| RPS19 | ribosomal protein S19 | -0.0238672 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0237509 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0236754 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0235391 |
| MYO1E | myosin IE | -0.0233101 |
| LDHA | lactate dehydrogenase A | -0.0229689 |
| COPA | coatomer protein complex, subunit alpha | -0.0229312 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0228924 |
| SVIL | supervillin | -0.022852 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0228327 |
| NDRG1 | N-myc downstream regulated 1 | -0.022724 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0226564 |
| HLA-A | major histocompatibility complex, class I, A | -0.0225303 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.022027 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0219031 |
| USP34 | ubiquitin specific peptidase 34 | -0.0218143 |
| RPL36 | ribosomal protein L36 | -0.021749 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.021609 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0215685 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0211265 |
| RPS8 | ribosomal protein S8 | -0.0207235 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.020694 |
| RPS23 | ribosomal protein S23 | -0.0205981 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0203851 |
| ATXN1 | ataxin 1 | -0.0201793 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.020154 |
| MCL1 | myeloid cell leukemia 1 | -0.0201025 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0197033 |
| RPL31 | ribosomal protein L31 | -0.0194811 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0194721 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0193521 |
| CD44 | CD44 molecule (Indian blood group) | -0.0189708 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.018936 |
| LAMA5 | laminin, alpha 5 | -0.0188226 |
| EXOC6B | exocyst complex component 6B | -0.0184695 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0182746 |
| IL6 | interleukin 6 | -0.0182096 |
| ARF4 | ADP-ribosylation factor 4 | -0.0180853 |
| NUMB | numb homolog (Drosophila) | -0.0179269 |
