| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | olaparib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the olaparib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.180671 |
| NDRG1 | N-myc downstream regulated 1 | 0.138414 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0968221 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0878195 |
| FAM13A | family with sequence similarity 13, member A | 0.0825234 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0768367 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0741052 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0730038 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0726646 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0725958 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0720872 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0714548 |
| LAMB3 | laminin, beta 3 | 0.0675178 |
| KRT17 | keratin 17, type I | 0.0672737 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0655732 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0648696 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0640999 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0635309 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0632912 |
| OGA | O-GlcNAcase | 0.0598245 |
| RBM39 | RNA binding motif protein 39 | 0.0588367 |
| MYO1E | myosin IE | 0.0585862 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0581548 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0562098 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0556253 |
| ZNF292 | zinc finger protein 292 | 0.0532037 |
| TPD52 | tumor protein D52 | 0.0531449 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.05147 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0512866 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0501857 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0500107 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0496832 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0492076 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.049018 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0489253 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0480324 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0479586 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0478112 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0477108 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0473135 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0466883 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0462658 |
| FOXO3 | forkhead box O3 | 0.0456369 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.045397 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.0452582 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0447818 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.044341 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0441337 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0440851 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.043617 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0434422 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0434303 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0432102 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0431225 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0423471 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.042069 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0417369 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0415638 |
| SMYD3 | SET and MYND domain containing 3 | 0.0413699 |
| PTGES2 | prostaglandin E synthase 2 | 0.0412597 |
| SDC4 | syndecan 4 | 0.0411117 |
| CCNY | cyclin Y | 0.0406339 |
| CANX | calnexin | 0.0402979 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.040196 |
| CA12 | carbonic anhydrase XII | 0.0398564 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0396946 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0396903 |
| FTL | ferritin, light polypeptide | 0.0392617 |
| ANXA1 | annexin A1 | 0.0388909 |
| JMJD1C | jumonji domain containing 1C | 0.0385453 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0384396 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0382757 |
| TXNIP | thioredoxin interacting protein | 0.0382336 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0377199 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0372485 |
| DST | dystonin | 0.0372288 |
| TXNRD1 | thioredoxin reductase 1 | 0.0370317 |
| DIAPH1 | diaphanous-related formin 1 | 0.0366647 |
| PKM | pyruvate kinase, muscle | 0.0365399 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0364318 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0362572 |
| RPL26 | ribosomal protein L26 | 0.0362389 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0360108 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0357443 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0357158 |
| RPS8 | ribosomal protein S8 | 0.0356391 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0352465 |
| FMNL2 | formin-like 2 | 0.0347935 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0344643 |
| CEP350 | centrosomal protein 350kDa | 0.0340817 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0339909 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0338529 |
| LDHA | lactate dehydrogenase A | 0.0336082 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0336063 |
| CPNE8 | copine VIII | 0.0334744 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0332284 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0331784 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0329825 |
| DIAPH2 | diaphanous-related formin 2 | 0.0325015 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0324307 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC16 | mucin 16, cell surface associated | -0.145405 |
| LMO7 | LIM domain 7 | -0.130052 |
| LAMC2 | laminin, gamma 2 | -0.120046 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.118495 |
| GRB10 | growth factor receptor-bound protein 10 | -0.110822 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0958418 |
| KIF13B | kinesin family member 13B | -0.0809322 |
| ATOSA | atos homolog A | -0.0783318 |
| RBM47 | RNA binding motif protein 47 | -0.0735408 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0710394 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0682986 |
| SPNS2 | spinster homolog 2 (Drosophila) | -0.0682181 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0672542 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0664913 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.065822 |
| EXOC6B | exocyst complex component 6B | -0.0655257 |
| KYNU | kynureninase | -0.0622325 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0615228 |
| INTS6 | integrator complex subunit 6 | -0.0612017 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0606501 |
| SCEL | sciellin | -0.059554 |
| TGFA | transforming growth factor, alpha | -0.057855 |
| ZNF638 | zinc finger protein 638 | -0.0577206 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0571105 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.057054 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0568063 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0565379 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0558527 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0558346 |
| VIM | vimentin | -0.0553692 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0538224 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0515922 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0505812 |
| CNKSR3 | CNKSR family member 3 | -0.0505192 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0501615 |
| ZNF185 | zinc finger protein 185 (LIM domain) | -0.0500143 |
| MUC13 | mucin 13, cell surface associated | -0.0494002 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0489692 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0479668 |
| OSMR | oncostatin M receptor | -0.0472814 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0471901 |
| STEAP4 | STEAP family member 4 | -0.0465889 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0463459 |
| TPCN1 | two pore segment channel 1 | -0.0462018 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | -0.0454936 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0453893 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.045304 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0450962 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0443365 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0440573 |
| TPM4 | tropomyosin 4 | -0.0434265 |
| SCFD1 | sec1 family domain containing 1 | -0.0421184 |
| PLSCR1 | phospholipid scramblase 1 | -0.0420956 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | -0.0420509 |
| ABHD17C | abhydrolase domain containing 17C | -0.0417693 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0417041 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0416786 |
| GOLGA3 | golgin A3 | -0.0401283 |
| FOSL2 | FOS-like antigen 2 | -0.0400692 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0400504 |
| MCU | mitochondrial calcium uniporter | -0.0391877 |
| ATP13A3 | ATPase type 13A3 | -0.03906 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0388492 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0385934 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0382611 |
| EFNA5 | ephrin-A5 | -0.0379603 |
| TJP2 | tight junction protein 2 | -0.037834 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0376446 |
| PMM2 | phosphomannomutase 2 | -0.0372106 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0371046 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0369453 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0368519 |
| ADAR | adenosine deaminase, RNA-specific | -0.0367046 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0364829 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0360956 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.0360005 |
| CCND1 | cyclin D1 | -0.0357423 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.035345 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0350151 |
| EGFR | epidermal growth factor receptor | -0.0346623 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0344153 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0343109 |
| SLMAP | sarcolemma associated protein | -0.0342668 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0340022 |
| PKN2 | protein kinase N2 | -0.0338862 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0338488 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.033721 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0336389 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0335199 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0334388 |
| FHIT | fragile histidine triad | -0.0330538 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0330056 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0329126 |
| SP100 | SP100 nuclear antigen | -0.0328814 |
| CLDN7 | claudin 7 | -0.0328781 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0328043 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.0327309 |
| PTMA | prothymosin, alpha | -0.032588 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0322052 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0321479 |
