| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | olaparib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the olaparib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.120785 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.102119 |
| YBX3 | Y box binding protein 3 | 0.0918381 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0894841 |
| RPS3 | ribosomal protein S3 | 0.085401 |
| TXNRD1 | thioredoxin reductase 1 | 0.076519 |
| RPL37A | ribosomal protein L37a | 0.0744012 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0704092 |
| PDE10A | phosphodiesterase 10A | 0.0704056 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0675881 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0586691 |
| RPS12 | ribosomal protein S12 | 0.0582459 |
| RPL26 | ribosomal protein L26 | 0.0563328 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.053244 |
| RPL37 | ribosomal protein L37 | 0.0495546 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0480237 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0471341 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.046326 |
| HLA-B | major histocompatibility complex, class I, B | 0.0457499 |
| RAD51B | RAD51 paralog B | 0.0446676 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0418591 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0404853 |
| RPL11 | ribosomal protein L11 | 0.0380091 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0361182 |
| ETV6 | ets variant 6 | 0.0350281 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0345756 |
| SLC38A2 | solute carrier family 38, member 2 | 0.034556 |
| OSMR | oncostatin M receptor | 0.0339607 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0339565 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0338636 |
| RPL9 | ribosomal protein L9 | 0.0335324 |
| PHF3 | PHD finger protein 3 | 0.0330596 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0325289 |
| RNF145 | ring finger protein 145 | 0.0324401 |
| RPL36A | ribosomal protein L36a | 0.0323599 |
| YAP1 | Yes-associated protein 1 | 0.031799 |
| RPL31 | ribosomal protein L31 | 0.0311706 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0310849 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0310709 |
| RPS10 | ribosomal protein S10 | 0.0304791 |
| RPL7A | ribosomal protein L7a | 0.0304469 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0300875 |
| RPLP2 | ribosomal protein, large, P2 | 0.0287989 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.028505 |
| RPL38 | ribosomal protein L38 | 0.0282366 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0282295 |
| RPS27A | ribosomal protein S27a | 0.028162 |
| PLSCR1 | phospholipid scramblase 1 | 0.0279395 |
| DENND5B | DENN/MADD domain containing 5B | 0.0277764 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0275402 |
| RPL19 | ribosomal protein L19 | 0.0274248 |
| RPS23 | ribosomal protein S23 | 0.0269302 |
| BMP5 | bone morphogenetic protein 5 | 0.0268205 |
| OGA | O-GlcNAcase | 0.0265414 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0262824 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0259841 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.025805 |
| RNF213 | ring finger protein 213 | 0.0258024 |
| RIGI | RNA sensor RIG-I | 0.0256608 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0255498 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 0.0254683 |
| LATS2 | large tumor suppressor kinase 2 | 0.0252118 |
| CAVIN1 | caveolae associated protein 1 | 0.0249307 |
| PHF21A | PHD finger protein 21A | 0.0245873 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0241593 |
| NCOA7 | nuclear receptor coactivator 7 | 0.024134 |
| FTL | ferritin, light polypeptide | 0.0238563 |
| MKI67 | marker of proliferation Ki-67 | 0.0236392 |
| RBM39 | RNA binding motif protein 39 | 0.023618 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.0234224 |
| WDR70 | WD repeat domain 70 | 0.0232883 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0232504 |
| RPS29 | ribosomal protein S29 | 0.0231809 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0226089 |
| NRDC | nardilysin convertase | 0.0225184 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0218253 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0216153 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0211536 |
| ANKRD36B | ankyrin repeat domain 36B | 0.0211474 |
| ZNF638 | zinc finger protein 638 | 0.0208513 |
| RPS8 | ribosomal protein S8 | 0.0207893 |
| RPS2 | ribosomal protein S2 | 0.0204599 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0204566 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0204332 |
| FOXP1 | forkhead box P1 | 0.0202534 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0201552 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0200304 |
| EXOC6B | exocyst complex component 6B | 0.0200049 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0199364 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0198008 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0197383 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0197235 |
| RPS17 | ribosomal protein S17 | 0.0195235 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0195214 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0193364 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | 0.0193321 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | 0.0190213 |
| CUL1 | cullin 1 | 0.0189771 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0189765 |
| RPS27 | ribosomal protein S27 | 0.0188125 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.208661 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.190325 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.18 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.120936 |
| EGR1 | early growth response 1 | -0.110947 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.108659 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.106963 |
| VIM | vimentin | -0.0961913 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.093918 |
| POTEF | POTE ankyrin domain family, member F | -0.0918503 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.084572 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0742414 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0678514 |
| ACTG1 | actin gamma 1 | -0.0670254 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0659959 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0590357 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.058852 |
| MORF4L2 | mortality factor 4 like 2 | -0.0562725 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0560286 |
| COPA | coatomer protein complex, subunit alpha | -0.0550089 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0548493 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0538223 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0522857 |
| CANX | calnexin | -0.0517097 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0477615 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.047403 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0467601 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0466917 |
| PFN1 | profilin 1 | -0.0465482 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0462799 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0454416 |
| MCL1 | myeloid cell leukemia 1 | -0.0450154 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0449905 |
| NF1 | neurofibromin 1 | -0.0445158 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0432328 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0427083 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0415141 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0412012 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0392569 |
| RTN4 | reticulon 4 | -0.0390374 |
| HMGA2 | high mobility group AT-hook 2 | -0.0390195 |
| TUBA1B | tubulin, alpha 1b | -0.0388953 |
| WASF2 | WAS protein family, member 2 | -0.0388495 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0388075 |
| PTMA | prothymosin, alpha | -0.0388068 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0377554 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0376831 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0370772 |
| RPLP0 | ribosomal protein, large, P0 | -0.0368088 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0366288 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0359574 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0358372 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0356161 |
| STC1 | stanniocalcin 1 | -0.0355531 |
| HMGA1 | high mobility group AT-hook 1 | -0.0354329 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0348143 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.034804 |
| ACTN1 | actinin, alpha 1 | -0.0347108 |
| SPAG9 | sperm associated antigen 9 | -0.0345444 |
| SCFD1 | sec1 family domain containing 1 | -0.0345322 |
| TAGLN2 | transgelin 2 | -0.0342039 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0340832 |
| UBC | ubiquitin C | -0.0337484 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0331819 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0326217 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0325021 |
| ARF4 | ADP-ribosylation factor 4 | -0.032293 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0321157 |
| RSF1 | remodeling and spacing factor 1 | -0.0320012 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0319945 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0318261 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0315449 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0315073 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0314486 |
| CDCP1 | CUB domain containing protein 1 | -0.0313818 |
| SRPK1 | SRSF protein kinase 1 | -0.0311947 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0307039 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.030333 |
| TPI1 | triosephosphate isomerase 1 | -0.0302852 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0297494 |
| TWF1 | twinfilin actin binding protein 1 | -0.029481 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | -0.0293867 |
| PCBP2 | poly(rC) binding protein 2 | -0.0292898 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0286719 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0281499 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0279398 |
| TAOK1 | TAO kinase 1 | -0.027878 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.027491 |
| NABP1 | nucleic acid binding protein 1 | -0.02749 |
| VMP1 | vacuole membrane protein 1 | -0.0274749 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0274702 |
| PKM | pyruvate kinase, muscle | -0.0274266 |
| SBF2 | SET binding factor 2 | -0.0273335 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0272963 |
| AFTPH | aftiphilin | -0.0272842 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0265984 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.026556 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.026525 |
| RHOA | ras homolog family member A | -0.0263784 |
| EREG | epiregulin | -0.0263221 |
