| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | olaparib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the olaparib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.220618 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.104362 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.100447 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0814814 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0797622 |
| RPS6 | ribosomal protein S6 | 0.0651491 |
| VEGFA | vascular endothelial growth factor A | 0.0617173 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0606039 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0591125 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0585831 |
| TPM3 | tropomyosin 3 | 0.0577219 |
| ARRDC3 | arrestin domain containing 3 | 0.0536561 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0469306 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0469132 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0464701 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0462845 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.044987 |
| RPS12 | ribosomal protein S12 | 0.0433132 |
| CCNL1 | cyclin L1 | 0.0426354 |
| SDC4 | syndecan 4 | 0.0418817 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0402265 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0380778 |
| FHIT | fragile histidine triad | 0.0379468 |
| MSN | moesin | 0.0374611 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0373863 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0358904 |
| TXNRD1 | thioredoxin reductase 1 | 0.0355402 |
| RPL9 | ribosomal protein L9 | 0.0353925 |
| FAM13A | family with sequence similarity 13, member A | 0.0350606 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0350122 |
| YBX1 | Y box binding protein 1 | 0.0349604 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0334653 |
| RPL11 | ribosomal protein L11 | 0.0328795 |
| ZNF292 | zinc finger protein 292 | 0.0324262 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0313312 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0311142 |
| RPL3 | ribosomal protein L3 | 0.0310625 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0309987 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0309751 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.030556 |
| RPS2 | ribosomal protein S2 | 0.030519 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0300592 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0297598 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0296491 |
| UPP1 | uridine phosphorylase 1 | 0.0293182 |
| NCKAP1 | NCK-associated protein 1 | 0.0282566 |
| PTK2 | protein tyrosine kinase 2 | 0.0277977 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.027607 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0264661 |
| MEF2A | myocyte enhancer factor 2A | 0.0264611 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0262819 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0262209 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0252761 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0248161 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0247955 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0242314 |
| RYBP | RING1 and YY1 binding protein | 0.0239513 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0237945 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0236172 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0234054 |
| MCL1 | myeloid cell leukemia 1 | 0.0231895 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0231287 |
| EZR | ezrin | 0.0231122 |
| MATR3 | matrin 3 | 0.0229149 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0227805 |
| PCBP2 | poly(rC) binding protein 2 | 0.0227353 |
| CLINT1 | clathrin interactor 1 | 0.022426 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0223396 |
| H1-4 | H1.4 linker histone, cluster member | 0.0222584 |
| ASPH | aspartate beta-hydroxylase | 0.0221383 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.02209 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0220764 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.02171 |
| ITGAV | integrin, alpha V | 0.0216321 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0213535 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0211801 |
| RPL4 | ribosomal protein L4 | 0.0211767 |
| HDGF | hepatoma-derived growth factor | 0.0211315 |
| DUSP5 | dual specificity phosphatase 5 | 0.0209823 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0209614 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.020953 |
| RPS17 | ribosomal protein S17 | 0.0208917 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.020787 |
| RPL7 | ribosomal protein L7 | 0.0207389 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0205168 |
| KIAA1217 | KIAA1217 | 0.0203852 |
| NPTN | neuroplastin | 0.0203465 |
| RPL5 | ribosomal protein L5 | 0.0203189 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0201824 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0201193 |
| XPO1 | exportin 1 | 0.0198539 |
| LAMB3 | laminin, beta 3 | 0.0195518 |
| CD83 | CD83 molecule | 0.0193127 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0192194 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0192047 |
| YBX3 | Y box binding protein 3 | 0.0190533 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0186693 |
| BRD2 | bromodomain containing 2 | 0.0184144 |
| RNF145 | ring finger protein 145 | 0.0183385 |
| TPD52 | tumor protein D52 | 0.0180854 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | -0.156433 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.130026 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.129514 |
| POTEF | POTE ankyrin domain family, member F | -0.125005 |
| LMO7 | LIM domain 7 | -0.118347 |
| FN1 | fibronectin 1 | -0.117621 |
| TMSB10 | thymosin beta 10 | -0.0949293 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0939402 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0771377 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.076333 |
| PTMA | prothymosin, alpha | -0.0723025 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0721141 |
| FTL | ferritin, light polypeptide | -0.0703087 |
| ERBIN | erbb2 interacting protein | -0.0660277 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0651426 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0643694 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0632709 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0612458 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.061142 |
| PGK1 | phosphoglycerate kinase 1 | -0.061061 |
| CD2AP | CD2-associated protein | -0.0602178 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0596735 |
| EFNA5 | ephrin-A5 | -0.0593003 |
| CCND1 | cyclin D1 | -0.0590629 |
| ARF1 | ADP-ribosylation factor 1 | -0.0583971 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0568271 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0547278 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0539282 |
| RASAL2 | RAS protein activator like 2 | -0.0537314 |
| TOP1 | topoisomerase (DNA) I | -0.0531739 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0527876 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0515856 |
| MYO6 | myosin VI | -0.0514265 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0510106 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0497196 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0491649 |
| TMSB4X | thymosin beta 4, X-linked | -0.0484625 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0451171 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0444105 |
| TMEM263 | transmembrane protein 263 | -0.0443643 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.043636 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0420287 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0410885 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0402173 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0397888 |
| S100A6 | S100 calcium binding protein A6 | -0.0393518 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0391598 |
| NF1 | neurofibromin 1 | -0.0391305 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0386931 |
| HMGA1 | high mobility group AT-hook 1 | -0.0385625 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0382566 |
| MAP4 | microtubule-associated protein 4 | -0.0381218 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0381162 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0379681 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0374736 |
| CSTB | cystatin B (stefin B) | -0.0373161 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0371324 |
| HDLBP | high density lipoprotein binding protein | -0.0370497 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0370335 |
| FAM107B | family with sequence similarity 107, member B | -0.0361708 |
| MCU | mitochondrial calcium uniporter | -0.0361465 |
| ENO1 | enolase 1, (alpha) | -0.036043 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0355275 |
| TPM4 | tropomyosin 4 | -0.0352144 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0351925 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0351599 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0348018 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0344647 |
| HLA-A | major histocompatibility complex, class I, A | -0.0339611 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0333204 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0332691 |
| MGLL | monoglyceride lipase | -0.0329802 |
| WASF2 | WAS protein family, member 2 | -0.0322878 |
| ANXA2 | annexin A2 | -0.0320872 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0318523 |
| NRP1 | neuropilin 1 | -0.0318437 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0317643 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0317009 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0316593 |
| KRT7 | keratin 7, type II | -0.0314634 |
| RHOA | ras homolog family member A | -0.0314026 |
| S100A10 | S100 calcium binding protein A10 | -0.031164 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0311493 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.0311169 |
| GNAS | GNAS complex locus | -0.0308074 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.03065 |
| UBAP1 | ubiquitin associated protein 1 | -0.0305832 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0305727 |
| COPA | coatomer protein complex, subunit alpha | -0.0305027 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0303889 |
| JMJD1C | jumonji domain containing 1C | -0.0298715 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0296131 |
| KRT19 | keratin 19, type I | -0.0295993 |
| RRBP1 | ribosome binding protein 1 | -0.0295733 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0294839 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.029132 |
| AOPEP | aminopeptidase O (putative) | -0.0288952 |
| FBXO11 | F-box protein 11 | -0.0288475 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.0285929 |
| GRB10 | growth factor receptor-bound protein 10 | -0.028321 |
