| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | olaparib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the olaparib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.253214 |
| EFNA5 | ephrin-A5 | 0.181275 |
| ASPH | aspartate beta-hydroxylase | 0.147914 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.108679 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.101698 |
| PTMA | prothymosin, alpha | 0.100764 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0905197 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0902102 |
| TXNRD1 | thioredoxin reductase 1 | 0.0855163 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0794675 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0788193 |
| OGA | O-GlcNAcase | 0.0778233 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0700005 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0678462 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0623331 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0603488 |
| GRAMD1B | GRAM domain containing 1B | 0.0601316 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0585917 |
| FAM13A | family with sequence similarity 13, member A | 0.0571603 |
| NEK7 | NIMA-related kinase 7 | 0.0562243 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.054993 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0544924 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0523366 |
| RBM39 | RNA binding motif protein 39 | 0.0521208 |
| SPAG9 | sperm associated antigen 9 | 0.0467415 |
| CENPF | centromere protein F, 350/400kDa | 0.0457085 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0451323 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0447576 |
| RTN4 | reticulon 4 | 0.0443375 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0427316 |
| MFF | mitochondrial fission factor | 0.0426567 |
| GDA | guanine deaminase | 0.0424404 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0411964 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0404824 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0404284 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0399314 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0392975 |
| NRCAM | neuronal cell adhesion molecule | 0.0391167 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0390431 |
| GOLGA4 | golgin A4 | 0.0384621 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0384132 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.038321 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0382434 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0377758 |
| RPS6 | ribosomal protein S6 | 0.03684 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.036562 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0362015 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0358157 |
| ZNF292 | zinc finger protein 292 | 0.0354101 |
| EZR | ezrin | 0.0347589 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0346662 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0338803 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0333291 |
| PGK1 | phosphoglycerate kinase 1 | 0.0333249 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0329556 |
| PTK2 | protein tyrosine kinase 2 | 0.0327787 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0322225 |
| PTGR1 | prostaglandin reductase 1 | 0.0319118 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0317369 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.031588 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.031371 |
| ANXA1 | annexin A1 | 0.0312951 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0311031 |
| CANX | calnexin | 0.0310266 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0310028 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0309013 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0306186 |
| PUM2 | pumilio RNA-binding family member 2 | 0.030616 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.03048 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0303533 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0301417 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0300632 |
| TNPO1 | transportin 1 | 0.0300203 |
| RAI1 | retinoic acid induced 1 | 0.0298327 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0297074 |
| MKI67 | marker of proliferation Ki-67 | 0.0296639 |
| INHBA | inhibin, beta A | 0.0296528 |
| SUCO | SUN domain containing ossification factor | 0.0295857 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0290911 |
| CTSL | cathepsin L | 0.0290881 |
| SEPTIN10 | septin 10 | 0.0289478 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0289289 |
| ARRDC3 | arrestin domain containing 3 | 0.02878 |
| MATR3 | matrin 3 | 0.0286121 |
| XPO1 | exportin 1 | 0.0285699 |
| FLNB | filamin B, beta | 0.0284742 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.028402 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0280985 |
| B2M | beta-2-microglobulin | 0.0277929 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0275184 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.027127 |
| CTSC | cathepsin C | 0.0266018 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0265717 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0265374 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0265299 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0264478 |
| TPR | translocated promoter region, nuclear basket protein | 0.0261675 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0261586 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0261502 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0261442 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.248196 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0803541 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0747346 |
| FN1 | fibronectin 1 | -0.0712475 |
| CDH13 | cadherin 13 | -0.0502656 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0463823 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.044346 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0443011 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0407252 |
| VCL | vinculin | -0.0405676 |
| LAMA5 | laminin, alpha 5 | -0.0400647 |
| FTL | ferritin, light polypeptide | -0.0399727 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0385647 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0384207 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0373059 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0354717 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0327692 |
| POTEF | POTE ankyrin domain family, member F | -0.031803 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.03071 |
| CTIF | CBP80/20-dependent translation initiation factor | -0.0302368 |
| SMAD2 | SMAD family member 2 | -0.0295709 |
| LSAMP | limbic system-associated membrane protein | -0.0294599 |
| EGR1 | early growth response 1 | -0.0293524 |
| PDE10A | phosphodiesterase 10A | -0.0277296 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0274953 |
| RAD51B | RAD51 paralog B | -0.0271195 |
| MAP7 | microtubule-associated protein 7 | -0.0269956 |
| FLNA | filamin A, alpha | -0.0267887 |
| INTS6 | integrator complex subunit 6 | -0.0254574 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0253153 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0242967 |
| AUTS2 | autism susceptibility candidate 2 | -0.0230973 |
| CHL1 | cell adhesion molecule L1-like | -0.0226762 |
| COL5A2 | collagen, type V, alpha 2 | -0.0217002 |
| RHOB | ras homolog family member B | -0.0214815 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | -0.0209384 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0206532 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0201722 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0200931 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0200449 |
| FOXK1 | forkhead box K1 | -0.0195165 |
| KRT19 | keratin 19, type I | -0.0188983 |
| EPHA4 | EPH receptor A4 | -0.0188302 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0187228 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0186462 |
| RPS24 | ribosomal protein S24 | -0.0186369 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0185518 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0181343 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0178238 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0176766 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0173116 |
| RACK1 | receptor for activated C kinase 1 | -0.0172793 |
| ACTG1 | actin gamma 1 | -0.0171569 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0169355 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0166493 |
| NTN4 | netrin 4 | -0.0166111 |
| RPL31 | ribosomal protein L31 | -0.0161634 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0158317 |
| RPS23 | ribosomal protein S23 | -0.0156773 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0156727 |
| TMEM144 | transmembrane protein 144 | -0.0155816 |
| NPAS2 | neuronal PAS domain protein 2 | -0.015484 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0153142 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.0148944 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.014826 |
| HDAC4 | histone deacetylase 4 | -0.0146253 |
| SQSTM1 | sequestosome 1 | -0.0144188 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0142699 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0141659 |
| PCDH9 | protocadherin 9 | -0.0140831 |
| CADM2 | cell adhesion molecule 2 | -0.0135786 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | -0.013569 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0133527 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0132499 |
| ZNF644 | zinc finger protein 644 | -0.0132185 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0131805 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0129756 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0128064 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0126952 |
| RPS3 | ribosomal protein S3 | -0.0126633 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0122572 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0120545 |
| SLCO1C1 | solute carrier organic anion transporter family, member 1C1 | -0.0120532 |
| NRXN3 | neurexin 3 | -0.0120468 |
| S100A11 | S100 calcium binding protein A11 | -0.0119814 |
| EGFR | epidermal growth factor receptor | -0.0119695 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0119653 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0119368 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0118811 |
| AEBP2 | AE binding protein 2 | -0.0118591 |
| IRS2 | insulin receptor substrate 2 | -0.0118528 |
| MEF2D | myocyte enhancer factor 2D | -0.0118322 |
| SVIL | supervillin | -0.011725 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0116802 |
| PFN1 | profilin 1 | -0.0116763 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0116568 |
| TBCA | tubulin folding cofactor A | -0.0116491 |
| RHOA | ras homolog family member A | -0.0116363 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0116309 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0115854 |
