olaparib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description olaparib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

185 genes differentially expressed following the olaparib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.223412
HELZ helicase with zinc finger 0.167044
IGF1R insulin-like growth factor 1 receptor 0.132553
MYO1E myosin IE 0.11543
PDE4D phosphodiesterase 4D, cAMP-specific 0.114046
KANSL1 KAT8 regulatory NSL complex subunit 1 0.108315
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.10483
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.102843
DSCAM Down syndrome cell adhesion molecule 0.102657
NBEA neurobeachin 0.0917157
ZCCHC7 zinc finger, CCHC domain containing 7 0.0909159
AKAP12 A kinase (PRKA) anchor protein 12 0.0818657
EFNA5 ephrin-A5 0.081528
ANKRD11 ankyrin repeat domain 11 0.0802706
SEC31A SEC31 homolog A (S. cerevisiae) 0.0770537
TENT2 terminal nucleotidyltransferase 2 0.0759803
SND1 staphylococcal nuclease and tudor domain containing 1 0.0755142
JMJD1C jumonji domain containing 1C 0.0720909
SBF2 SET binding factor 2 0.0689489
FOXJ3 forkhead box J3 0.0688925
EZR ezrin 0.0663712
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0663398
PRELID2 PRELI domain containing 2 0.0662651
DLG1 discs, large homolog 1 (Drosophila) 0.0657363
SPAG9 sperm associated antigen 9 0.0649321
NRG1 neuregulin 1 0.0643982
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0597828
SETD2 SET domain containing 2 0.0558173
WSB1 WD repeat and SOCS box containing 1 0.0548828
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0545619
GNAS GNAS complex locus 0.0532955
SLTM SAFB-like, transcription modulator 0.0522304
EPS8 epidermal growth factor receptor pathway substrate 8 0.0520177
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0519623
MSI2 musashi RNA-binding protein 2 0.0490474
LAMA4 laminin, alpha 4 0.0487107
SCAF11 SR-related CTD-associated factor 11 0.0469937
PRKCA protein kinase C, alpha 0.0457365
NAMPT nicotinamide phosphoribosyltransferase 0.0450318
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0450148
OSBPL9 oxysterol binding protein-like 9 0.0444602
PARD3 par-3 family cell polarity regulator 0.0440895
MBNL2 muscleblind-like splicing regulator 2 0.0403487
CNKSR3 CNKSR family member 3 0.0400757
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0395258
EGFR epidermal growth factor receptor 0.0392014
BIRC6 baculoviral IAP repeat containing 6 0.0384106
TRIO trio Rho guanine nucleotide exchange factor 0.0351547
LPP LIM domain containing preferred translocation partner in lipoma 0.0337435
RAB10 RAB10, member RAS oncogene family 0.032136
GPC6 glypican 6 0.0314356
NFIA nuclear factor I/A 0.0277234
NAP1L1 nucleosome assembly protein 1-like 1 0.0269879
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0262437
SETD5 SET domain containing 5 0.0262158
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0242795
ZNF292 zinc finger protein 292 0.0241653
PKM pyruvate kinase, muscle 0.0234964
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.023235
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0229785
KMT2C lysine (K)-specific methyltransferase 2C 0.0209452
PSD3 pleckstrin and Sec7 domain containing 3 0.0206883
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0204459
PTK2 protein tyrosine kinase 2 0.0203674
ELL2 elongation factor, RNA polymerase II, 2 0.0198198
DOCK5 dedicator of cytokinesis 5 0.0193982
NF1 neurofibromin 1 0.0186501
USP34 ubiquitin specific peptidase 34 0.0181536
CHD1 chromodomain helicase DNA binding protein 1 0.017497
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0157945
PRKG1 protein kinase, cGMP-dependent, type I 0.0150976
ASPH aspartate beta-hydroxylase 0.0148728
TXNRD1 thioredoxin reductase 1 0.0146925
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0141016
NALF1 NALCN channel auxiliary factor 1 0.0132111
FAM13A family with sequence similarity 13, member A 0.0120757
AKAP13 A kinase (PRKA) anchor protein 13 0.0118841
RAB1A RAB1A, member RAS oncogene family 0.00859991
CARD16 caspase recruitment domain family, member 16 0.00739601
EXT1 exostosin glycosyltransferase 1 0.00680533
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.00663962
RERE arginine-glutamic acid dipeptide (RE) repeats 0.00649093
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.00599512
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0035635
WNK1 WNK lysine deficient protein kinase 1 0.00237433

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.152284
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.151804
NKD1 naked cuticle homolog 1 (Drosophila) -0.12143
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.118336
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.106571
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0989107
INTS6 integrator complex subunit 6 -0.098377
HMGA1 high mobility group AT-hook 1 -0.0979378
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0867885
HDLBP high density lipoprotein binding protein -0.0867213
EGR1 early growth response 1 -0.0816546
NAV2 neuron navigator 2 -0.0772607
ENO1 enolase 1, (alpha) -0.0754131
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.075044
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0748329
RPL12 ribosomal protein L12 -0.074031
TTC3 tetratricopeptide repeat domain 3 -0.0722059
RPS24 ribosomal protein S24 -0.0691229
RABGAP1L RAB GTPase activating protein 1-like -0.068514
SYT1 synaptotagmin I -0.0682397
RPS12 ribosomal protein S12 -0.0682372
TMSB10 thymosin beta 10 -0.0655955
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0632084
TBC1D22A TBC1 domain family, member 22A -0.0630528
GPHN gephyrin -0.0612152
FN1 fibronectin 1 -0.0602256
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0598333
HMGA2 high mobility group AT-hook 2 -0.0590415
RPL31 ribosomal protein L31 -0.0578254
GLG1 golgi glycoprotein 1 -0.0566591
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0563876
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0555688
PRRC2C proline-rich coiled-coil 2C -0.0555038
ZNF638 zinc finger protein 638 -0.0549953
PDE10A phosphodiesterase 10A -0.05471
PTPRM protein tyrosine phosphatase, receptor type, M -0.0542425
RPL19 ribosomal protein L19 -0.0530319
EEF2 eukaryotic translation elongation factor 2 -0.0520287
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0504286
FTL ferritin, light polypeptide -0.0493523
TENM3 teneurin transmembrane protein 3 -0.0491451
SRRM2 serine/arginine repetitive matrix 2 -0.0483385
MAML2 mastermind-like 2 (Drosophila) -0.0459652
MBD5 methyl-CpG binding domain protein 5 -0.0455379
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0450742
VIM vimentin -0.0447471
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.044374
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0432211
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0429017
RPLP1 ribosomal protein, large, P1 -0.0425908
RPS8 ribosomal protein S8 -0.0425375
RAD51B RAD51 paralog B -0.0416549
AKAP9 A kinase (PRKA) anchor protein 9 -0.040919
NDRG1 N-myc downstream regulated 1 -0.0405833
KTN1 kinectin 1 (kinesin receptor) -0.0403944
CMIP c-Maf inducing protein -0.0386858
RPL37 ribosomal protein L37 -0.0383686
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0378075
ADAR adenosine deaminase, RNA-specific -0.0333868
ANKRD12 ankyrin repeat domain 12 -0.0332803
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0323776
TPM4 tropomyosin 4 -0.0315238
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0314282
TPT1 tumor protein, translationally-controlled 1 -0.0312519
RPL13A ribosomal protein L13a -0.0311313
LDHA lactate dehydrogenase A -0.0308449
PDLIM5 PDZ and LIM domain 5 -0.0298384
ACTG1 actin gamma 1 -0.0291282
ZBTB20 zinc finger and BTB domain containing 20 -0.029062
SQSTM1 sequestosome 1 -0.028812
SMYD3 SET and MYND domain containing 3 -0.0288112
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0280199
B2M beta-2-microglobulin -0.0278667
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0271539
FNDC3B fibronectin type III domain containing 3B -0.0266292
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0261966
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0258734
RPS16 ribosomal protein S16 -0.0242232
APP amyloid beta (A4) precursor protein -0.0241325
RNF213 ring finger protein 213 -0.0238261
ANXA2 annexin A2 -0.0236158
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0233126
PTMA prothymosin, alpha -0.0202764
SLC38A2 solute carrier family 38, member 2 -0.0202581
GMDS GDP-mannose 4,6-dehydratase -0.0194711
DST dystonin -0.0186747
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0184761
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0157953
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0150493
CSNK1A1 casein kinase 1, alpha 1 -0.01474
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0146355
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0144996
VCL vinculin -0.0141985
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0138481
DENND1A DENN/MADD domain containing 1A -0.0135038
GOLGA4 golgin A4 -0.01234
EXOC6B exocyst complex component 6B -0.0116057
RPS6 ribosomal protein S6 -0.0115841
AHNAK AHNAK nucleoprotein -0.00977986
PGK1 phosphoglycerate kinase 1 -0.0089685