| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | olaparib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the olaparib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.163304 |
| COL3A1 | collagen, type III, alpha 1 | 0.11219 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.100534 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0946326 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0713171 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0695397 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0686033 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0643295 |
| THBS1 | thrombospondin 1 | 0.0637525 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0632546 |
| PTMA | prothymosin, alpha | 0.0620829 |
| COL5A2 | collagen, type V, alpha 2 | 0.0581176 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0557802 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0554952 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0529045 |
| H1-4 | H1.4 linker histone, cluster member | 0.0524854 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0514667 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0498946 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0486735 |
| COL1A2 | collagen, type I, alpha 2 | 0.047623 |
| ANXA1 | annexin A1 | 0.0470228 |
| RPS6 | ribosomal protein S6 | 0.0454781 |
| CALR | calreticulin | 0.044764 |
| USP3 | ubiquitin specific peptidase 3 | 0.0442338 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0440576 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0436992 |
| EMP1 | epithelial membrane protein 1 | 0.0429595 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0429525 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0424706 |
| STAG2 | stromal antigen 2 | 0.042052 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0400249 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0398524 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0393929 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0392751 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.039104 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0380989 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0379703 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0378612 |
| RFX7 | regulatory factor X, 7 | 0.037802 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0375746 |
| RAI1 | retinoic acid induced 1 | 0.0362463 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0361542 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.0361003 |
| PRTG | protogenin | 0.0357722 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0354462 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0351851 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0350352 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0348484 |
| MATR3 | matrin 3 | 0.0347993 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0347233 |
| PDGFC | platelet derived growth factor C | 0.0344665 |
| METAP2 | methionyl aminopeptidase 2 | 0.03442 |
| RHEB | Ras homolog enriched in brain | 0.0341504 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0340716 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0332697 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0331169 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.0326001 |
| OGA | O-GlcNAcase | 0.0325896 |
| JMJD1C | jumonji domain containing 1C | 0.0325269 |
| RHOH | ras homolog family member H | 0.0323808 |
| ENAH | enabled homolog (Drosophila) | 0.03233 |
| MYO10 | myosin X | 0.0322823 |
| TPM3 | tropomyosin 3 | 0.0322715 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0322114 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0321721 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0320059 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0319843 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0319656 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0316219 |
| USP53 | ubiquitin specific peptidase 53 | 0.0310391 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0308256 |
| RLF | rearranged L-myc fusion | 0.0307883 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0304822 |
| SFRP4 | secreted frizzled-related protein 4 | 0.0304201 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0302508 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0300264 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0300213 |
| EAPP | E2F-associated phosphoprotein | 0.0299701 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0298849 |
| RPL37 | ribosomal protein L37 | 0.0293776 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0292559 |
| NTM | neurotrimin | 0.0292406 |
| DENND4A | DENN/MADD domain containing 4A | 0.0291522 |
| NCKAP1 | NCK-associated protein 1 | 0.029138 |
| FAM168A | family with sequence similarity 168, member A | 0.0290971 |
| SNX6 | sorting nexin 6 | 0.0289588 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0288009 |
| ZFHX4 | zinc finger homeobox 4 | 0.0285552 |
| RPL34 | ribosomal protein L34 | 0.0284234 |
| NUDT3 | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | 0.028336 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0282198 |
| QKI | QKI, KH domain containing, RNA binding | 0.0280714 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0279286 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0279115 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.0277986 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0277325 |
| RBM39 | RNA binding motif protein 39 | 0.0274219 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0274195 |
| TUT4 | terminal uridylyl transferase 4 | 0.0273605 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.027132 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.125444 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.108265 |
| CADM2 | cell adhesion molecule 2 | -0.0644888 |
| NHSL1 | NHS-like 1 | -0.0537529 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0534186 |
| SYT1 | synaptotagmin I | -0.0501721 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0475233 |
| NRG1 | neuregulin 1 | -0.0454324 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0447898 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0422663 |
| TEX11 | testis expressed 11 | -0.042249 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0414018 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0409433 |
| SPAG9 | sperm associated antigen 9 | -0.0409134 |
| NEBL | nebulette | -0.0398251 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0368139 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0366293 |
| POTEF | POTE ankyrin domain family, member F | -0.0363369 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0350693 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0350347 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0345827 |
| ACTG1 | actin gamma 1 | -0.0336472 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0334401 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0333971 |
| UTRN | utrophin | -0.0333644 |
| INTS6 | integrator complex subunit 6 | -0.032856 |
| CDK6 | cyclin-dependent kinase 6 | -0.0321549 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0314188 |
| RHOA | ras homolog family member A | -0.0312681 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.0309851 |
| ECT2 | epithelial cell transforming 2 | -0.0306004 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0300252 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0294588 |
| PFN1 | profilin 1 | -0.02941 |
| FNIP1 | folliculin interacting protein 1 | -0.0292778 |
| BRMS1L | breast cancer metastasis-suppressor 1-like | -0.0282552 |
| MKI67 | marker of proliferation Ki-67 | -0.0278825 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0277653 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -0.0276924 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.0270824 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0266484 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0265805 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.0259815 |
| SGO2 | shugoshin 2 | -0.0257823 |
| CENPE | centromere protein E, 312kDa | -0.0254139 |
| SSH2 | slingshot protein phosphatase 2 | -0.0250758 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0248766 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0247003 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0244924 |
| FOXK1 | forkhead box K1 | -0.0242246 |
| GAB2 | GRB2-associated binding protein 2 | -0.0240053 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0239933 |
| OSTM1 | osteopetrosis associated transmembrane protein 1 | -0.0236908 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0235585 |
| NDC80 | NDC80 kinetochore complex component | -0.0235195 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.0235169 |
| TPX2 | TPX2, microtubule-associated | -0.0234578 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0233254 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0227799 |
| RIC8B | RIC8 guanine nucleotide exchange factor B | -0.0226575 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0225016 |
| FAT1 | FAT atypical cadherin 1 | -0.0222112 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0221355 |
| UBN2 | ubinuclein 2 | -0.0221109 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.0220835 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0220601 |
| NOTCH2 | notch 2 | -0.0219954 |
| LIN52 | lin-52 DREAM MuvB core complex component | -0.0219631 |
| UBL3 | ubiquitin-like 3 | -0.0217736 |
| STIL | SCL/TAL1 interrupting locus | -0.0216929 |
| ATXN1 | ataxin 1 | -0.0216736 |
| N4BP2 | NEDD4 binding protein 2 | -0.0215697 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0215013 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | -0.021471 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0213522 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0210831 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0210072 |
| RNASEH2A | ribonuclease H2, subunit A | -0.0209869 |
| RAB10 | RAB10, member RAS oncogene family | -0.0209795 |
| DEPDC1 | DEP domain containing 1 | -0.020965 |
| NCOA1 | nuclear receptor coactivator 1 | -0.020958 |
| MTCL1 | microtubule crosslinking factor 1 | -0.0208164 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0207976 |
| CLIC4 | chloride intracellular channel 4 | -0.0206895 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0206118 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.020599 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0204156 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.02039 |
| MAP4 | microtubule-associated protein 4 | -0.0203095 |
| GANAB | glucosidase, alpha; neutral AB | -0.0202573 |
| SQSTM1 | sequestosome 1 | -0.0202281 |
| LOC112694756 | uncharaterized LOC112694756 | -0.020147 |
| CHFR | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | -0.0199617 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0198851 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | -0.0198746 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0198698 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0198166 |
| KLHL5 | kelch-like family member 5 | -0.0197146 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.0196105 |
| NFX1 | nuclear transcription factor, X-box binding 1 | -0.0195894 |
