oligodendroglioma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO.)|A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)|A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO)|A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO.)|A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms (MeSH).|A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor of adults, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). It generally recurs locally, with median post-operative survival times ranging from 3 to 5 years for patients with all histological grades. (Adapted from WHO.) (Experimental Factor Ontology, EFO_0000632)
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Genes

249 genes co-occuring with the disease oligodendroglioma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 2.05945
OLIG2 oligodendrocyte lineage transcription factor 2 1.77451
SYP synaptophysin 1.59117
FUBP1 far upstream element (FUSE) binding protein 1 1.57111
GFAP glial fibrillary acidic protein 1.50447
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.43464
CFH complement factor H 1.38778
TP53 tumor protein p53 1.36858
ENO2 enolase 2 (gamma, neuronal) 1.2521
KLHL30 kelch-like family member 30 1.17035
MGMT O-6-methylguanine-DNA methyltransferase 1.16136
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 1.1312
UGT8 UDP glycosyltransferase 8 1.10804
ATAD2B ATPase family, AAA domain containing 2B 1.09377
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1.08286
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 1.07698
OLIG1 oligodendrocyte transcription factor 1 1.06816
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 1.04756
MXD4 MAX dimerization protein 4 1.02271
PTEN phosphatase and tensin homolog 1.01301
SLITRK3 SLIT and NTRK-like family, member 3 0.982215
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.981794
EGFR epidermal growth factor receptor 0.97296
AGO2 argonaute RISC catalytic component 2 0.929173
PARVG parvin, gamma 0.923387
B3GAT1 beta-1,3-glucuronyltransferase 1 0.914727
NKX2-2 NK2 homeobox 2 0.910199
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.90732
CDKN2A cyclin-dependent kinase inhibitor 2A 0.900335
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.898693
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.889258
GLTSCR2 glioma tumor suppressor candidate region gene 2 0.876966
EMP3 epithelial membrane protein 3 0.869596
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 0.868368
TRIM8 tripartite motif containing 8 0.851173
SLITRK2 SLIT and NTRK-like family, member 2 0.849126
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.828639
ZGPAT zinc finger, CCCH-type with G patch domain 0.825768
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.80936
SLITRK4 SLIT and NTRK-like family, member 4 0.804436
SLITRK5 SLIT and NTRK-like family, member 5 0.801154
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 0.797052
GLTSCR1 glioma tumor suppressor candidate region gene 1 0.784345
RND2 Rho family GTPase 2 0.774114
KIAA1549 KIAA1549 0.763902
NEURL1 neuralized E3 ubiquitin protein ligase 1 0.761862
RIMS2 regulating synaptic membrane exocytosis 2 0.756156
ZNF296 zinc finger protein 296 0.748017
MBP myelin basic protein 0.74436
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 0.738676
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 0.734217
PDGFB platelet-derived growth factor beta polypeptide 0.719654
SLITRK6 SLIT and NTRK-like family, member 6 0.714811
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 0.713601
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.712796
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.712392
EHD2 EH-domain containing 2 0.691896
ABHD2 abhydrolase domain containing 2 0.686291
DLL3 delta-like 3 (Drosophila) 0.685491
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.680697
PLXNC1 plexin C1 0.671527
ONECUT2 one cut homeobox 2 0.655254
HRC histidine rich calcium binding protein 0.636708
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.626888
NOTCH2NL notch 2 N-terminal like 0.624927
C1QBP complement component 1, q subcomponent binding protein 0.623751
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.612792
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.608885
SPAG16 sperm associated antigen 16 0.605762
PPAP2B phosphatidic acid phosphatase type 2B 0.594454
ASPA aspartoacylase 0.594064
MYT1L myelin transcription factor 1-like 0.593285
HOXD1 homeobox D1 0.587833
RTN4 reticulon 4 0.585108
DBF4 DBF4 zinc finger 0.583163
MOCS1 molybdenum cofactor synthesis 1 0.568775
RPS9 ribosomal protein S9 0.566054
CNOT1 CCR4-NOT transcription complex, subunit 1 0.561392
PRKG2 protein kinase, cGMP-dependent, type II 0.559839
CDK4 cyclin-dependent kinase 4 0.556732
INA internexin neuronal intermediate filament protein, alpha 0.547032
FHOD1 formin homology 2 domain containing 1 0.547032
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 0.533475
CIC capicua transcriptional repressor 0.52729
DAAM2 dishevelled associated activator of morphogenesis 2 0.526518
FMNL2 formin-like 2 0.524974
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.524202
CHMP2A charged multivesicular body protein 2A 0.51842
CCDC26 CCDC26 long non-coding RNA 0.51611
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 0.51534
BEX1 brain expressed, X-linked 1 0.506507
BEX2 brain expressed X-linked 2 0.506123
PHLDB1 pleckstrin homology-like domain, family B, member 1 0.504973
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.503824
FMNL1 formin-like 1 0.502675
IRX6 iroquois homeobox 6 0.501909
PNMAL1 paraneoplastic Ma antigen family-like 1 0.499997
MDM4 MDM4, p53 regulator 0.496557
PDGFA platelet-derived growth factor alpha polypeptide 0.495793
CAMTA1 calmodulin binding transcription activator 1 0.491597
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.490454
SOX10 SRY (sex determining region Y)-box 10 0.489691
CSNK1E casein kinase 1, epsilon 0.487788
RBBP5 retinoblastoma binding protein 5 0.487027
CAPG capping protein (actin filament), gelsolin-like 0.487027
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.483985
MOBP myelin-associated oligodendrocyte basic protein 0.478668
NOTCH2 notch 2 0.476772
PTCRA pre T-cell antigen receptor alpha 0.476393
NES nestin 0.462772
DTX1 deltex 1, E3 ubiquitin ligase 0.45447
DIAPH2 diaphanous-related formin 2 0.451454
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.451078
MSH6 mutS homolog 6 0.448817
PCNA proliferating cell nuclear antigen 0.44129
GALC galactosylceramidase 0.429266
IRX3 iroquois homeobox 3 0.42739
GNAS GNAS complex locus 0.424389
PTPRB protein tyrosine phosphatase, receptor type, B 0.42139
FOXJ2 forkhead box J2 0.416896
DPYSL3 dihydropyrimidinase-like 3 0.41465
RAB11A RAB11A, member RAS oncogene family 0.407919
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.404931
CASD1 CAS1 domain containing 1 0.402318
ADAM19 ADAM metallopeptidase domain 19 0.40008
TDGF1 teratocarcinoma-derived growth factor 1 0.395235
POU2F1 POU class 2 homeobox 1 0.394863
DAAM1 dishevelled associated activator of morphogenesis 1 0.391141
RTEL1 regulator of telomere elongation helicase 1 0.390025
ITGB4 integrin, beta 4 0.384079
FMN2 formin 2 0.384079
DIAPH1 diaphanous-related formin 1 0.382966
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.376661
MAP2 microtubule-associated protein 2 0.365193
ACSS2 acyl-CoA synthetase short-chain family member 2 0.361502
WNT6 wingless-type MMTV integration site family, member 6 0.361133
QKI QKI, KH domain containing, RNA binding 0.355972
TANK TRAF family member-associated NFKB activator 0.355235
MSI1 musashi RNA-binding protein 1 0.347511
HOXD10 homeobox D10 0.346777
FGD1 FYVE, RhoGEF and PH domain containing 1 0.346409
CHRD chordin 0.345308
UBA1 ubiquitin-like modifier activating enzyme 1 0.340906
AJAP1 adherens junctions associated protein 1 0.339073
GSTT1 glutathione S-transferase theta 1 0.332121
GSTTP1 glutathione S-transferase theta pseudogene 1 0.332121
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.328105
NPAS2 neuronal PAS domain protein 2 0.326646
SOX6 SRY (sex determining region Y)-box 6 0.318635
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 0.316092
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.315729
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.314278
MELK maternal embryonic leucine zipper kinase 0.313915
NF1 neurofibromin 1 0.312464
RICTOR RPTOR independent companion of MTOR, complex 2 0.311739
RPL11 ribosomal protein L11 0.304864
RPL18 ribosomal protein L18 0.300173
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.298731
GLIS3 GLIS family zinc finger 3 0.298011
HRAS Harvey rat sarcoma viral oncogene homolog 0.295132
RAP1GAP RAP1 GTPase activating protein 0.295132
COL14A1 collagen, type XIV, alpha 1 0.28616
LMO1 LIM domain only 1 (rhombotin 1) 0.285802
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.284728
ATAD2 ATPase family, AAA domain containing 2 0.283655
GLI1 GLI family zinc finger 1 0.280796
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.279367
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.278654
ICT1 immature colon carcinoma transcript 1 0.277584
OPHN1 oligophrenin 1 0.275445
GPC1 glypican 1 0.275089
SULF2 sulfatase 2 0.274021
PDCD5 programmed cell death 5 0.271174
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.269398
METTL13 methyltransferase like 13 0.269043
PEG3 paternally expressed 3 0.269043
BTG2 BTG family, member 2 0.267977
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.266203
PLP1 proteolipid protein 1 0.264077
PTCH2 patched 2 0.261599
MKI67 marker of proliferation Ki-67 0.257005
FABP7 fatty acid binding protein 7, brain 0.256299
FNDC3A fibronectin type III domain containing 3A 0.251366
CD34 CD34 molecule 0.238403
MAT2A methionine adenosyltransferase II, alpha 0.238054
NCAN neurocan 0.237357
GALE UDP-galactose-4-epimerase 0.235964
PROM1 prominin 1 0.23492
MLH1 mutL homolog 1 0.233878
CRY2 cryptochrome circadian clock 2 0.230063
ITGB8 integrin, beta 8 0.229024
TJP2 tight junction protein 2 0.227642
CCND1 cyclin D1 0.223165
THEM5 thioesterase superfamily member 5 0.220081
LGALS3 lectin, galactoside-binding, soluble, 3 0.217352
RB1 retinoblastoma 1 0.217352
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.215653
SCRT1 scratch family zinc finger 1 0.214636
IQGAP1 IQ motif containing GTPase activating protein 1 0.214297
KLF10 Kruppel-like factor 10 0.212608
BCAN brevican 0.210925
ITGB6 integrin, beta 6 0.205916
DIO2 deiodinase, iodothyronine, type II 0.205585
ACLY ATP citrate lyase 0.205254
SOX3 SRY (sex determining region Y)-box 3 0.200982
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.198064
CD68 CD68 molecule 0.197742
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.197742
FABP3 fatty acid binding protein 3, muscle and heart 0.197742
GCLM glutamate-cysteine ligase, modifier subunit 0.19742
IFNB1 interferon, beta 1, fibroblast 0.197099
ITGB7 integrin, beta 7 0.196779
ADAM8 ADAM metallopeptidase domain 8 0.196459
REST RE1-silencing transcription factor 0.196139
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 0.196139
GREM1 gremlin 1, DAN family BMP antagonist 0.194232
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.192971
SOX1 SRY (sex determining region Y)-box 1 0.192971
GADD45G growth arrest and DNA-damage-inducible, gamma 0.188938
SOX17 SRY (sex determining region Y)-box 17 0.186811
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.18651
SMAD5 SMAD family member 5 0.185612
CRYAB crystallin, alpha B 0.184128
CRY1 cryptochrome circadian clock 1 0.18151
AIF1 allograft inflammatory factor 1 0.179802
CLOCK clock circadian regulator 0.175146
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.174881
HSPA4 heat shock 70kDa protein 4 0.174093
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.171286
MRI1 methylthioribose-1-phosphate isomerase 1 0.169812
LIG1 ligase I, DNA, ATP-dependent 0.169091
SAR1A secretion associated, Ras related GTPase 1A 0.168617
POU5F1B POU class 5 homeobox 1B 0.168617
RAP2B RAP2B, member of RAS oncogene family 0.166768
FMN1 formin 1 0.165655
MIR10B microRNA 10b 0.164786
RAB1B RAB1B, member RAS oncogene family 0.164571
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.163523
TP73 tumor protein p73 0.163043
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.162707
F8 coagulation factor VIII, procoagulant component 0.160761
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.160387
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.15948
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 0.159302
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.158778
PMEL premelanosome protein 0.158266
ARF3 ADP-ribosylation factor 3 0.157929
MX2 MX dynamin-like GTPase 2 0.157929
DPYD dihydropyrimidine dehydrogenase 0.144535