onchocerciasis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy. (Human Disease Ontology, DOID_11678)
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Genes

99 genes co-occuring with the disease onchocerciasis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SRCIN1 SRC kinase signaling inhibitor 1 3.32436
ONECUT3 one cut homeobox 3 1.79931
MFF mitochondrial fission factor 1.76004
CALR calreticulin 1.10048
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 1.05429
TREH trehalase (brush-border membrane glycoprotein) 1.01976
IL5 interleukin 5 0.978426
SNIP1 Smad nuclear interacting protein 1 0.882701
APOD apolipoprotein D 0.817976
RBP3 retinol binding protein 3, interstitial 0.805257
EPX eosinophil peroxidase 0.797052
SAG S-antigen; retina and pineal gland (arrestin) 0.792541
EPT1 ethanolaminephosphotransferase 1 0.778613
ZAN zonadhesin (gene/pseudogene) 0.773296
RNASE3 ribonuclease, RNase A family, 3 0.735838
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64) 0.731786
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.722482
KIF1BP KIF1 binding protein 0.69751
GSTA2 glutathione S-transferase alpha 2 0.689893
GSTA1 glutathione S-transferase alpha 1 0.682294
GSTA3 glutathione S-transferase alpha 3 0.644586
GSTA4 glutathione S-transferase alpha 4 0.642221
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 0.635921
PTDSS1 phosphatidylserine synthase 1 0.625319
CHD7 chromodomain helicase DNA binding protein 7 0.605372
RNF19B ring finger protein 19B 0.603811
MRO maestro 0.59874
TLR6 toll-like receptor 6 0.591337
CCL3 chemokine (C-C motif) ligand 3 0.580828
ALAD aminolevulinate dehydratase 0.579272
HPGDS hematopoietic prostaglandin D synthase 0.543155
CCL4 chemokine (C-C motif) ligand 4 0.542379
SHPK sedoheptulokinase 0.53657
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.51188
CCL23 chemokine (C-C motif) ligand 23 0.509576
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.505739
CD4 CD4 molecule 0.493122
TPM1 tropomyosin 1 (alpha) 0.484364
PPT2 palmitoyl-protein thioesterase 2 0.480566
PKD2L1 polycystic kidney disease 2-like 1 0.469954
MPI mannose phosphate isomerase 0.466172
S100A9 S100 calcium binding protein A9 0.464283
CD79A CD79a molecule, immunoglobulin-associated alpha 0.461639
LEMD3 LEM domain containing 3 0.455601
ANK2 ankyrin 2, neuronal 0.453339
GALE UDP-galactose-4-epimerase 0.424765
FRY furry homolog (Drosophila) 0.387423
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.381481
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.381481
MED28 mediator complex subunit 28 0.379626
GLS2 glutaminase 2 (liver, mitochondrial) 0.368518
CCL27 chemokine (C-C motif) ligand 27 0.366301
CCL15 chemokine (C-C motif) ligand 15 0.365193
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 0.359289
IL4 interleukin 4 0.356709
ACPP acid phosphatase, prostate 0.35082
EFNA5 ephrin-A5 0.35082
SIL1 SIL1 nucleotide exchange factor 0.332121
CCL24 chemokine (C-C motif) ligand 24 0.323002
AGA aspartylglucosaminidase 0.308842
CCL17 chemokine (C-C motif) ligand 17 0.30848
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.305948
SI sucrase-isomaltase (alpha-glucosidase) 0.305948
SPAG9 sperm associated antigen 9 0.300533
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.299812
CD48 CD48 molecule 0.298011
LST1 leukocyte specific transcript 1 0.296931
MPO myeloperoxidase 0.296931
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.292975
SIRT5 sirtuin 5 0.288668
TGFB1 transforming growth factor, beta 1 0.283297
CCL13 chemokine (C-C motif) ligand 13 0.275801
TLR2 toll-like receptor 2 0.266203
LARGE like-glycosyltransferase 0.257005
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.242945
PTGDR prostaglandin D2 receptor (DP) 0.238054
DES desmin 0.224884
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.222822
TLR4 toll-like receptor 4 0.218034
EPGN epithelial mitogen 0.213621
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.212608
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.205916
CCL7 chemokine (C-C motif) ligand 7 0.202618
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.193915
IFNGR1 interferon gamma receptor 1 0.188326
GPER1 G protein-coupled estrogen receptor 1 0.18472
NONO non-POU domain containing, octamer-binding 0.183835
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.178403
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.177576
PRSS21 protease, serine, 21 (testisin) 0.176485
P4HB prolyl 4-hydroxylase, beta polypeptide 0.175411
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.173571
NBPF10 neuroblastoma breakpoint family, member 10 0.16933
GUSB glucuronidase, beta 0.165655
RPE ribulose-5-phosphate-3-epimerase 0.165435
NEFH neurofilament, heavy polypeptide 0.163938
DSG1 desmoglein 1 0.163317
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 0.159838
IL10 interleukin 10 0.158778