open-angle glaucoma Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage. (Human Disease Ontology, DOID_1067)
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30 genes associated with the disease open-angle glaucoma in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
ATOH7 atonal homolog 7 (Drosophila) 1.82268
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.80795
LOC100506532 uncharacterized LOC100506532 1.51636
COL5A1 collagen, type V, alpha 1 1.49655
COL8A2 collagen, type VIII, alpha 2 1.48283
ADPRHL2 ADP-ribosylhydrolase like 2 1.44827
CHEK2 checkpoint kinase 2 1.42467
DCLK1 doublecortin-like kinase 1 1.42467
BCAS3 breast carcinoma amplified sequence 3 1.37327
RERE arginine-glutamic acid dipeptide (RE) repeats 1.33878
FNDC3B fibronectin type III domain containing 3B 1.30364
RFTN1 raftlin, lipid raft linker 1 1.28906
MYPN myopalladin 1.28906
AKAP6 A kinase (PRKA) anchor protein 6 1.27942
ARID3A AT rich interactive domain 3A (BRIGHT-like) 1.26953
LRP1B low density lipoprotein receptor-related protein 1B 1.26953
IDO2 indoleamine 2,3-dioxygenase 2 1.25886
FAM53B family with sequence similarity 53, member B 1.24687
TRAPPC3 trafficking protein particle complex 3 1.22325
FAM175B family with sequence similarity 175, member B 1.21296
LINC00290 long intergenic non-protein coding RNA 290 1.17589
SCFD2 sec1 family domain containing 2 1.14463
DENND2A DENN/MADD domain containing 2A 1.07599
TSHR thyroid stimulating hormone receptor 1.07599
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 1.02684
SDK1 sidekick cell adhesion molecule 1 1.0181
PEX14 peroxisomal biogenesis factor 14 1.00407
ESRRG estrogen-related receptor gamma 1.00407
PIAS2 protein inhibitor of activated STAT, 2 0.976976
MYH9 myosin, heavy chain 9, non-muscle 0.971169