opiate dependence Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance. (Human Disease Ontology, DOID_2559)
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Genes

186 genes co-occuring with the disease opiate dependence in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
OPRM1 opioid receptor, mu 1 1.95206
DSTN destrin (actin depolymerizing factor) 1.58626
NPFF neuropeptide FF-amide peptide precursor 1.55114
FOS FBJ murine osteosarcoma viral oncogene homolog 1.45968
DRD4 dopamine receptor D4 1.34635
PDYN prodynorphin 1.33109
FYB FYN binding protein 1.29746
DRD2 dopamine receptor D2 1.28566
NISCH nischarin 1.23516
PENK proenkephalin 1.22649
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 1.21738
CREB1 cAMP responsive element binding protein 1 1.20093
CCKBR cholecystokinin B receptor 1.16992
OPRD1 opioid receptor, delta 1 1.09251
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.0753
OPRL1 opiate receptor-like 1 1.06942
ANKK1 ankyrin repeat and kinase domain containing 1 1.05219
ADCY2 adenylate cyclase 2 (brain) 1.0463
CCK cholecystokinin 1.03956
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.0244
TH tyrosine hydroxylase 1.01174
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.990644
CRH corticotropin releasing hormone 0.987271
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.955361
AUTS2 autism susceptibility candidate 2 0.944521
NRXN3 neurexin 3 0.927519
CRHR1 corticotropin releasing hormone receptor 1 0.925039
CNR1 cannabinoid receptor 1 (brain) 0.917611
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.904032
DRD3 dopamine receptor D3 0.902799
BDNF brain-derived neurotrophic factor 0.897461
CREB3 cAMP responsive element binding protein 3 0.897461
PNOC prepronociceptin 0.88516
MAOA monoamine oxidase A 0.866321
EPHB1 EPH receptor B1 0.852811
COMT catechol-O-methyltransferase 0.838476
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.836427
ADORA1 adenosine A1 receptor 0.815514
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.803616
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.801564
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.793361
DAD1 defender against cell death 1 0.763086
POMC proopiomelanocortin 0.730571
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 0.728952
ADCY8 adenylate cyclase 8 (brain) 0.719654
TTC12 tetratricopeptide repeat domain 12 0.715215
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.714005
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 0.691896
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 0.682693
CSNK1E casein kinase 1, epsilon 0.673518
OPRK1 opioid receptor, kappa 1 0.671925
DRD1 dopamine receptor D1 0.668742
ACPT acid phosphatase, testicular 0.668742
GAL galanin/GMAP prepropeptide 0.663578
ARF4 ADP-ribosylation factor 4 0.663578
CCKAR cholecystokinin A receptor 0.625711
LY96 lymphocyte antigen 96 0.6214
GALR3 galanin receptor 3 0.616703
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.606152
CREB3L4 cAMP responsive element binding protein 3-like 4 0.605372
DLL1 delta-like 1 (Drosophila) 0.604981
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.59952
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.598351
MC5R melanocortin 5 receptor 0.586276
TECR trans-2,3-enoyl-CoA reductase 0.580828
EPHB2 EPH receptor B2 0.5645
CIRBP cold inducible RNA binding protein 0.551686
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.541992
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.531541
HSPH1 heat shock 105kDa/110kDa protein 1 0.524588
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.521117
ADCY4 adenylate cyclase 4 0.517649
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.514571
CNTN3 contactin 3 (plasmacytoma associated) 0.514186
ARRB1 arrestin, beta 1 0.514186
ADCY7 adenylate cyclase 7 0.496557
NOS1 nitric oxide synthase 1 (neuronal) 0.489691
NOTO notochord homeobox 0.483604
GALR1 galanin receptor 1 0.482084
GDNF glial cell derived neurotrophic factor 0.481325
TAC1 tachykinin, precursor 1 0.480566
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.477909
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.474119
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.464283
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.462394
ADORA2A adenosine A2a receptor 0.449194
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.446935
ADCY1 adenylate cyclase 1 (brain) 0.446558
ADCY3 adenylate cyclase 3 0.445052
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 0.437906
GRM3 glutamate receptor, metabotropic 3 0.436778
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.431144
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.430768
MAPK7 mitogen-activated protein kinase 7 0.430017
ACTG1 actin gamma 1 0.428516
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.424765
ADCY10 adenylate cyclase 10 (soluble) 0.42139
TPH2 tryptophan hydroxylase 2 0.420266
INSC inscuteable homolog (Drosophila) 0.419142
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.419142
ADCY9 adenylate cyclase 9 0.399707
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.397843
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.397098
OPN3 opsin 3 0.396725
RGMB repulsive guidance molecule family member b 0.39598
ADCY6 adenylate cyclase 6 0.389653
ADCY5 adenylate cyclase 5 0.386679
HOMER1 homer scaffolding protein 1 0.382223
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.378514
DCXR dicarbonyl/L-xylulose reductase 0.370737
NTF3 neurotrophin 3 0.363347
NPSR1 neuropeptide S receptor 1 0.358551
DRD5 dopamine receptor D5 0.352291
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.342372
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.340906
ABAT 4-aminobutyrate aminotransferase 0.340539
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.324458
NPS neuropeptide S 0.319726
FHL1 four and a half LIM domains 1 0.313915
MGP matrix Gla protein 0.30848
RGS4 regulator of G-protein signaling 4 0.305948
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.304142
ACTB actin, beta 0.303059
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.299092
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.289027
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.28831
TDO2 tryptophan 2,3-dioxygenase 0.287593
CRHR2 corticotropin releasing hormone receptor 2 0.27153
AGPS alkylglycerone phosphate synthase 0.266203
CXADR coxsackie virus and adenovirus receptor 0.265849
FKBP5 FK506 binding protein 5 0.258064
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.256299
DTNBP1 dystrobrevin binding protein 1 0.254536
EFNB1 ephrin-B1 0.251015
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.244345
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.243995
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.235268
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.23492
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.232489
GYPA glycophorin A (MNS blood group) 0.232489
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.231795
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.226952
NRL neural retina leucine zipper 0.224884
NPR1 natriuretic peptide receptor 1 0.218715
NOVA2 neuro-oncological ventral antigen 2 0.218034
GUCY2C guanylate cyclase 2C 0.217693
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.217352
CHM choroideremia (Rab escort protein 1) 0.210253
NLE1 notchless homolog 1 (Drosophila) 0.203275
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 0.203275
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.201962
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.199033
PLCG1 phospholipase C, gamma 1 0.194548
MGAM maltase-glucoamylase 0.18472
HSPA4 heat shock 70kDa protein 4 0.18151
NOS2 nitric oxide synthase 2, inducible 0.177851
JUN jun proto-oncogene 0.174093
HSPB1 heat shock 27kDa protein 1 0.169571
PEBP1 phosphatidylethanolamine binding protein 1 0.167915
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.164571
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.162109
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.161716
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.160021
PER3 period circadian clock 3 0.141867
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.141828
HAS1 hyaluronan synthase 1 0.141438
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.140567
CORT cortistatin 0.139954
GRM1 glutamate receptor, metabotropic 1 0.139115
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.138941
PSENEN presenilin enhancer gamma secretase subunit 0.138941
NEUROD1 neuronal differentiation 1 0.138737
EXT1 exostosin glycosyltransferase 1 0.138663
F2R coagulation factor II (thrombin) receptor 0.138501
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.138489
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.138015
NPY neuropeptide Y 0.137779
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.137593
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.136971
HSPA8 heat shock 70kDa protein 8 0.136257
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.136222
HCRT hypocretin (orexin) neuropeptide precursor 0.136205
ENO2 enolase 2 (gamma, neuronal) 0.136081
CNTF ciliary neurotrophic factor 0.135717
TPH1 tryptophan hydroxylase 1 0.134957
GRM5 glutamate receptor, metabotropic 5 0.134895