osteoarthritis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans. (Experimental Factor Ontology, EFO_0002506)
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Genes

706 genes co-occuring with the disease osteoarthritis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ACAN aggrecan 2.90508
MMP13 matrix metallopeptidase 13 2.74894
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 2.46059
MMP3 matrix metallopeptidase 3 2.42686
COMP cartilage oligomeric matrix protein 2.37886
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 2.31225
IL1B interleukin 1, beta 2.2706
MMP1 matrix metallopeptidase 1 2.16917
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 2.15509
COL2A1 collagen, type II, alpha 1 2.15406
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.05765
SOX9 SRY (sex determining region Y)-box 9 1.82595
GDF5 growth differentiation factor 5 1.79841
ASPN asporin 1.79165
TIMP1 TIMP metallopeptidase inhibitor 1 1.77044
TNF tumor necrosis factor 1.7546
CMC1 C-x(9)-C motif containing 1 1.72775
MATN3 matrilin 3 1.71043
COL10A1 collagen, type X, alpha 1 1.68136
TRIM47 tripartite motif containing 47 1.6791
FRZB frizzled-related protein 1.63411
PRG4 proteoglycan 4 1.58983
FMOD fibromodulin 1.57913
TGFB1 transforming growth factor, beta 1 1.56267
CRP C-reactive protein, pentraxin-related 1.55424
IL1A interleukin 1, alpha 1.52776
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 1.5093
IGF1 insulin-like growth factor 1 (somatomedin C) 1.49087
COL6A4P1 collagen, type VI, alpha 4 pseudogene 1 1.48779
IL6 interleukin 6 1.45572
MMP9 matrix metallopeptidase 9 1.44298
BMP2 bone morphogenetic protein 2 1.44035
COL9A1 collagen, type IX, alpha 1 1.43859
BGLAP bone gamma-carboxyglutamate (gla) protein 1.41183
IL1RN interleukin 1 receptor antagonist 1.41008
COL9A2 collagen, type IX, alpha 2 1.40351
MATN1 matrilin 1, cartilage matrix protein 1.38559
SP9 Sp9 transcription factor 1.37425
BGN biglycan 1.37207
RUNX2 runt-related transcription factor 2 1.35943
PTGES prostaglandin E synthase 1.35376
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.35071
LCTL lactase-like 1.34374
CTSK cathepsin K 1.3385
ALPL alkaline phosphatase, liver/bone/kidney 1.33021
ALPPL2 alkaline phosphatase, placental-like 2 1.31537
ALPP alkaline phosphatase, placental 1.31493
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 1.30794
MMP2 matrix metallopeptidase 2 1.30532
FN1 fibronectin 1 1.29571
ACRV1 acrosomal vesicle protein 1 1.29483
COL9A3 collagen, type IX, alpha 3 1.28086
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.27083
BMP7 bone morphogenetic protein 7 1.2582
CD68 CD68 molecule 1.25124
DDR2 discoidin domain receptor tyrosine kinase 2 1.24819
IHH indian hedgehog 1.2395
DCN decorin 1.2382
NOTCH1 notch 1 1.22779
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 1.20007
JUN jun proto-oncogene 1.19489
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.19186
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 1.18152
SMAD3 SMAD family member 3 1.17722
PHB2 prohibitin 2 1.16649
TAC1 tachykinin, precursor 1 1.1605
CALCA calcitonin-related polypeptide alpha 1.15283
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 1.13501
COG5 component of oligomeric golgi complex 5 1.13501
TIMP2 TIMP metallopeptidase inhibitor 2 1.12698
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.12572
LEP leptin 1.1253
CD44 CD44 molecule (Indian blood group) 1.12193
HAPLN1 hyaluronan and proteoglycan link protein 1 1.12024
CTSS cathepsin S 1.11351
FGF2 fibroblast growth factor 2 (basic) 1.09377
COL1A1 collagen, type I, alpha 1 1.08831
OSM oncostatin M 1.07866
IBSP integrin-binding sialoprotein 1.07866
COL11A1 collagen, type XI, alpha 1 1.0648
GPR22 G protein-coupled receptor 22 1.06396
COL11A2 collagen, type XI, alpha 2 1.06102
MRPL49 mitochondrial ribosomal protein L49 1.05807
CCL2 chemokine (C-C motif) ligand 2 1.05807
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 1.05765
BMP5 bone morphogenetic protein 5 1.05051
LAX1 lymphocyte transmembrane adaptor 1 1.04966
TRAPPC2 trafficking protein particle complex 2 1.04714
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 1.04672
SIK1 salt-inducible kinase 1 1.04462
IL17A interleukin 17A 1.02482
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.02271
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 1.01891
ACPP acid phosphatase, prostate 1.01807
NME8 NME/NM23 family member 8 1.01469
XYLT1 xylosyltransferase I 1.00499
CXCL8 chemokine (C-X-C motif) ligand 8 1.00288
MCF2L MCF.2 cell line derived transforming sequence-like 1.00035
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 0.997392
PLAU plasminogen activator, urokinase 0.979689
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.978426
TGFB3 transforming growth factor, beta 3 0.97086
SPP1 secreted phosphoprotein 1 0.963309
KRT86 keratin 86, type II 0.962472
MMP8 matrix metallopeptidase 8 0.944938
PTHLH parathyroid hormone-like hormone 0.942027
NGF nerve growth factor (beta polypeptide) 0.941196
CHI3L2 chitinase 3-like 2 0.932898
ADAM12 ADAM metallopeptidase domain 12 0.931656
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.923387
HAS1 hyaluronan synthase 1 0.918436
ALOX5 arachidonate 5-lipoxygenase 0.912668
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.904442
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.904032
NOS2 nitric oxide synthase 2, inducible 0.899514
DIO2 deiodinase, iodothyronine, type II 0.889258
MAPK8 mitogen-activated protein kinase 8 0.889258
LUM lumican 0.877376
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.875329
B3GAT3 beta-1,3-glucuronyltransferase 3 0.872053
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.870825
IL1R1 interleukin 1 receptor, type I 0.869596
SOX5 SRY (sex determining region Y)-box 5 0.863046
ANKH ANKH inorganic pyrophosphate transport regulator 0.862637
AMICA1 adhesion molecule, interacts with CXADR antigen 1 0.859362
SMAD2 SMAD family member 2 0.851583
PTH parathyroid hormone 0.851173
CTSB cathepsin B 0.850764
CXCL12 chemokine (C-X-C motif) ligand 12 0.849126
SOD2 superoxide dismutase 2, mitochondrial 0.848716
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.846259
IL18 interleukin 18 0.84585
ICAM1 intercellular adhesion molecule 1 0.84544
TIMP3 TIMP metallopeptidase inhibitor 3 0.822077
NPS neuropeptide S 0.821257
A1BG alpha-1-B glycoprotein 0.815514
CTGF connective tissue growth factor 0.815514
CD4 CD4 molecule 0.811411
SEBOX SEBOX homeobox 0.808539
HTRA1 HtrA serine peptidase 1 0.807718
PLA2G1B phospholipase A2, group IB (pancreas) 0.806898
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.804846
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.801564
MAPK14 mitogen-activated protein kinase 14 0.801154
IVD isovaleryl-CoA dehydrogenase 0.798692
TLR4 toll-like receptor 4 0.791311
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.788852
MARK3 MAP/microtubule affinity-regulating kinase 3 0.787623
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.787623
PLG plasminogen 0.786394
IL34 interleukin 34 0.785984
HAS2 hyaluronan synthase 2 0.785574
LOX lysyl oxidase 0.779023
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.776159
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.774523
BCAP29 B-cell receptor-associated protein 29 0.77207
ESR1 estrogen receptor 1 0.76921
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 0.763494
WNT16 wingless-type MMTV integration site family, member 16 0.760639
SDC4 syndecan 4 0.759008
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.757786
FOS FBJ murine osteosarcoma viral oncogene homolog 0.757786
HGD homogentisate 1,2-dioxygenase 0.755749
MSLNL mesothelin-like 0.754527
MATN4 matrilin 4 0.752898
NAMPT nicotinamide phosphoribosyltransferase 0.749237
TNC tenascin C 0.744766
COL1A2 collagen, type I, alpha 2 0.74436
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.743547
ANXA5 annexin A5 0.73746
SOST sclerostin 0.732191
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.72329
TGFB2 transforming growth factor, beta 2 0.722886
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.722482
CCL8 chemokine (C-C motif) ligand 8 0.71925
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.71925
RETN resistin 0.718846
VCAM1 vascular cell adhesion molecule 1 0.718443
MMP28 matrix metallopeptidase 28 0.718443
THY1 Thy-1 cell surface antigen 0.714005
TLR2 toll-like receptor 2 0.708364
IGFBP3 insulin-like growth factor binding protein 3 0.707559
MMP25 matrix metallopeptidase 25 0.707559
CCL3 chemokine (C-C motif) ligand 3 0.703536
FGF18 fibroblast growth factor 18 0.70233
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.700722
SOX6 SRY (sex determining region Y)-box 6 0.700321
ALB albumin 0.691094
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.690694
PDCD5 programmed cell death 5 0.689092
HMGB1 high mobility group box 1 0.678302
LRP5 low density lipoprotein receptor-related protein 5 0.676308
WISP1 WNT1 inducible signaling pathway protein 1 0.673518
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.667152
VCAN versican 0.666755
XYLT2 xylosyltransferase II 0.663975
KRT36 keratin 36, type I 0.663578
ESR2 estrogen receptor 2 (ER beta) 0.661197
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.659215
CXCL10 chemokine (C-X-C motif) ligand 10 0.656837
CHAD chondroadherin 0.655254
MCM8 minichromosome maintenance complex component 8 0.65288
MED12 mediator complex subunit 12 0.643009
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.642615
PADI4 peptidyl arginine deiminase, type IV 0.637889
IGFBP5 insulin-like growth factor binding protein 5 0.636315
BMP6 bone morphogenetic protein 6 0.632777
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 0.631991
SFRP1 secreted frizzled-related protein 1 0.631205
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.630813
AGER advanced glycosylation end product-specific receptor 0.626495
BCAN brevican 0.620617
CCL20 chemokine (C-C motif) ligand 20 0.617877
ZNF780B zinc finger protein 780B 0.612011
SCAF8 SR-related CTD-associated factor 8 0.612011
ZNF470 zinc finger protein 470 0.612011
SPP2 secreted phosphoprotein 2, 24kDa 0.612011
ZNF155 zinc finger protein 155 0.612011
CSNK1A1L casein kinase 1, alpha 1-like 0.612011
TLR3 toll-like receptor 3 0.608494
FGF1 fibroblast growth factor 1 (acidic) 0.608104
S100A8 S100 calcium binding protein A8 0.606543
IL10 interleukin 10 0.606543
MMP12 matrix metallopeptidase 12 0.59991
VIP vasoactive intestinal peptide 0.59991
KITLG KIT ligand 0.59952
PTGES2 prostaglandin E synthase 2 0.596792
PPARG peroxisome proliferator-activated receptor gamma 0.595623
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.592895
CCL5 chemokine (C-C motif) ligand 5 0.592116
S100A12 S100 calcium binding protein A12 0.591337
CXCL6 chemokine (C-X-C motif) ligand 6 0.587444
APOL3 apolipoprotein L, 3 0.587054
CTSD cathepsin D 0.587054
VEGFA vascular endothelial growth factor A 0.586665
IL4 interleukin 4 0.58433
AKAP8L A kinase (PRKA) anchor protein 8-like 0.58005
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.579661
CARD17 caspase recruitment domain family, member 17 0.579272
RPAIN RPA interacting protein 0.578494
KNG1 kininogen 1 0.577716
TSKU tsukushi, small leucine rich proteoglycan 0.571884
CLEC3B C-type lectin domain family 3, member B 0.570718
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.570329
MIA melanoma inhibitory activity 0.564889
MMP7 matrix metallopeptidase 7 0.561781
CXCL5 chemokine (C-X-C motif) ligand 5 0.561004
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 0.560227
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 0.559062
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.557509
HFE hemochromatosis 0.552463
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.551686
CLCF1 cardiotrophin-like cytokine factor 1 0.550911
MAPK3 mitogen-activated protein kinase 3 0.549747
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.546644
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.546256
CD79A CD79a molecule, immunoglobulin-associated alpha 0.545868
WNT3A wingless-type MMTV integration site family, member 3A 0.545093
SRY sex determining region Y 0.54393
ELANE elastase, neutrophil expressed 0.542379
HCST hematopoietic cell signal transducer 0.535796
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.535022
MIR146A microRNA 146a 0.533861
COL5A1 collagen, type V, alpha 1 0.533475
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.533475
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.533088
THBS1 thrombospondin 1 0.532314
CAT catalase 0.528063
LTF lactotransferrin 0.524202
SAAL1 serum amyloid A-like 1 0.523045
SP7 Sp7 transcription factor 0.523045
THUMPD1 THUMP domain containing 1 0.521888
BMP4 bone morphogenetic protein 4 0.520346
CALCR calcitonin receptor 0.51842
STAT1 signal transducer and activator of transcription 1, 91kDa 0.51534
DEAF1 DEAF1 transcription factor 0.511496
IL32 interleukin 32 0.510728
ADIPOR1 adiponectin receptor 1 0.510344
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.509576
PARD3B par-3 family cell polarity regulator beta 0.508041
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.508041
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.506507
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.505356
DOT1L DOT1-like histone H3K79 methyltransferase 0.50459
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.504207
IL15 interleukin 15 0.502292
COL3A1 collagen, type III, alpha 1 0.499614
PMFBP1 polyamine modulated factor 1 binding protein 1 0.496557
IL16 interleukin 16 0.496175
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.493885
CD163 CD163 molecule 0.49274
C1S complement component 1, s subcomponent 0.491215
PTN pleiotrophin 0.490454
HBA2 hemoglobin, alpha 2 0.490072
SIRT1 sirtuin 1 0.48893
CILP2 cartilage intermediate layer protein 2 0.487788
SOD1 superoxide dismutase 1, soluble 0.486646
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 0.485505
UNC93A unc-93 homolog A (C. elegans) 0.484744
POSTN periostin, osteoblast specific factor 0.483985
ADAMDEC1 ADAM-like, decysin 1 0.483224
LAMP3 lysosomal-associated membrane protein 3 0.478289
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.475255
VWF von Willebrand factor 0.475255
RHOB ras homolog family member B 0.472225
INS insulin 0.471846
CHPF chondroitin polymerizing factor 0.471089
CTSG cathepsin G 0.467684
TGFBR1 transforming growth factor, beta receptor 1 0.464283
FASLG Fas ligand (TNF superfamily, member 6) 0.462394
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.460883
DNTT DNA nucleotidylexotransferase 0.458241
COL27A1 collagen, type XXVII, alpha 1 0.457487
BSG basigin (Ok blood group) 0.456732
ADAM15 ADAM metallopeptidase domain 15 0.456355
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.455601
S100A11 S100 calcium binding protein A11 0.455224
POMC proopiomelanocortin 0.452208
HSPA4 heat shock 70kDa protein 4 0.451831
MAP2K3 mitogen-activated protein kinase kinase 3 0.449571
SELE selectin E 0.449194
PRELP proline/arginine-rich end leucine-rich repeat protein 0.448064
LPAR1 lysophosphatidic acid receptor 1 0.447687
IL2RA interleukin 2 receptor, alpha 0.445805
LEPR leptin receptor 0.4443
BAX BCL2-associated X protein 0.439786
MGP matrix Gla protein 0.439034
MRC2 mannose receptor, C type 2 0.435275
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.434899
CCR6 chemokine (C-C motif) receptor 6 0.434899
CMKLR1 chemerin chemokine-like receptor 1 0.434524
MMP17 matrix metallopeptidase 17 (membrane-inserted) 0.430017
PEPD peptidase D 0.430017
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.429642
PGRMC1 progesterone receptor membrane component 1 0.429642
LTBP2 latent transforming growth factor beta binding protein 2 0.428516
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.427765
GUSB glucuronidase, beta 0.427015
PTH1R parathyroid hormone 1 receptor 0.425514
OLAH oleoyl-ACP hydrolase 0.424014
TIMP4 TIMP metallopeptidase inhibitor 4 0.423265
UGDH UDP-glucose 6-dehydrogenase 0.42289
GDF10 growth differentiation factor 10 0.42289
C5AR1 complement component 5a receptor 1 0.42214
PRTG protogenin 0.421016
SOCS3 suppressor of cytokine signaling 3 0.420266
CP ceruloplasmin (ferroxidase) 0.419892
CD34 CD34 molecule 0.419892
APOL2 apolipoprotein L, 2 0.419892
HYAL1 hyaluronoglucosaminidase 1 0.419517
LAP3 leucine aminopeptidase 3 0.419517
TSPO translocator protein (18kDa) 0.419142
SENP6 SUMO1/sentrin specific peptidase 6 0.41465
SSC5D scavenger receptor cysteine rich family, 5 domains 0.413153
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.413153
NCOA1 nuclear receptor coactivator 1 0.413153
IL33 interleukin 33 0.412031
FZD5 frizzled class receptor 5 0.410535
CFI complement factor I 0.409787
ADIPOR2 adiponectin receptor 2 0.407545
LECT1 leukocyte cell derived chemotaxin 1 0.407172
CHSY1 chondroitin sulfate synthase 1 0.406425
CD38 CD38 molecule 0.405305
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.403811
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.403811
GPX5 glutathione peroxidase 5 0.403064
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.400826
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.399707
GPX4 glutathione peroxidase 4 0.399707
IRAK3 interleukin-1 receptor-associated kinase 3 0.397471
COL15A1 collagen, type XV, alpha 1 0.397098
CYTL1 cytokine-like 1 0.392629
GLB1 galactosidase, beta 1 0.392257
CXCR2 chemokine (C-X-C motif) receptor 2 0.391141
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.390397
HMGB2 high mobility group box 2 0.388538
IL2 interleukin 2 0.387051
FTH1 ferritin, heavy polypeptide 1 0.386308
GPX1 glutathione peroxidase 1 0.384822
CXCL3 chemokine (C-X-C motif) ligand 3 0.384822
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.382594
INHBA inhibin, beta A 0.382594
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.381852
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 0.381852
TP53 tumor protein p53 0.381852
MOAP1 modulator of apoptosis 1 0.377402
CHRD chordin 0.377402
JAM3 junctional adhesion molecule 3 0.373698
ATF3 activating transcription factor 3 0.370368
C1R complement component 1, r subcomponent 0.367779
GPC4 glypican 4 0.366671
THBS3 thrombospondin 3 0.365932
FTL ferritin, light polypeptide 0.365193
CXCL2 chemokine (C-X-C motif) ligand 2 0.364454
S100A9 S100 calcium binding protein A9 0.362978
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.360764
MPO myeloperoxidase 0.360764
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.359657
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.359289
HBP1 HMG-box transcription factor 1 0.356709
MMP10 matrix metallopeptidase 10 0.353763
LOC102724852 uncharacterized LOC102724852 0.353763
ANGPTL4 angiopoietin-like 4 0.353395
S100A4 S100 calcium binding protein A4 0.353395
DLK2 delta-like 2 homolog (Drosophila) 0.351555
ACTG1 actin gamma 1 0.35082
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.348614
MRAP melanocortin 2 receptor accessory protein 0.347511
FGF7 fibroblast growth factor 7 0.347511
TGM2 transglutaminase 2 0.346777
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.346409
KANK4 KN motif and ankyrin repeat domains 4 0.344941
HBA1 hemoglobin, alpha 1 0.344574
RGS10 regulator of G-protein signaling 10 0.342372
ACTB actin, beta 0.340906
CXCR3 chemokine (C-X-C motif) receptor 3 0.33944
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.338707
HPR haptoglobin-related protein 0.33651
OLIG3 oligodendrocyte transcription factor 3 0.335046
FZD2 frizzled class receptor 2 0.334681
B2M beta-2-microglobulin 0.334681
PPA1 pyrophosphatase (inorganic) 1 0.332121
ACE angiotensin I converting enzyme 0.332121
PDGFB platelet-derived growth factor beta polypeptide 0.331025
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.33066
LTBP3 latent transforming growth factor beta binding protein 3 0.330295
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.32993
CRCP CGRP receptor component 0.329565
UXS1 UDP-glucuronate decarboxylase 1 0.3292
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.328834
WNT8A wingless-type MMTV integration site family, member 8A 0.32774
IL23A interleukin 23, alpha subunit p19 0.326646
NCR3 natural cytotoxicity triggering receptor 3 0.326281
CXCR1 chemokine (C-X-C motif) receptor 1 0.326281
TLR1 toll-like receptor 1 0.324823
CFP complement factor properdin 0.323002
TF transferrin 0.322273
IGF1R insulin-like growth factor 1 receptor 0.322273
TTR transthyretin 0.322273
WNT7B wingless-type MMTV integration site family, member 7B 0.321545
CREM cAMP responsive element modulator 0.320454
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.32009
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.318272
HIP1R huntingtin interacting protein 1 related 0.317545
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.317182
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.317182
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.315729
BMPR1A bone morphogenetic protein receptor, type IA 0.31464
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.313915
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.313189
NOG noggin 0.312102
GPC2 glypican 2 0.311014
WDFY3 WD repeat and FYVE domain containing 3 0.309566
PCNA proliferating cell nuclear antigen 0.309204
HP haptoglobin 0.308118
TMEM163 transmembrane protein 163 0.307757
ADGRE5 adhesion G protein-coupled receptor E5 0.305587
VIPR1 vasoactive intestinal peptide receptor 1 0.305587
CCL3L1 chemokine (C-C motif) ligand 3-like 1 0.304503
CFL1 cofilin 1 (non-muscle) 0.304142
ITGA10 integrin, alpha 10 0.30342
AQP1 aquaporin 1 (Colton blood group) 0.302337
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.302337
FAM195A family with sequence similarity 195, member A 0.301615
HYAL2 hyaluronoglucosaminidase 2 0.299452
KLHL42 kelch-like family member 42 0.299092
DVL2 dishevelled segment polarity protein 2 0.298371
PADI2 peptidyl arginine deiminase, type II 0.298011
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.297291
MIR223 microRNA 223 0.296571
PARP1 poly (ADP-ribose) polymerase 1 0.296571
EPAS1 endothelial PAS domain protein 1 0.295132
BTNL2 butyrophilin-like 2 0.295132
SAA1 serum amyloid A1 0.291898
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.291539
MRI1 methylthioribose-1-phosphate isomerase 1 0.290462
GADD45B growth arrest and DNA-damage-inducible, beta 0.290462
SNX9 sorting nexin 9 0.289386
EGFL8 EGF-like-domain, multiple 8 0.289027
KIN Kin17 DNA and RNA binding protein 0.28616
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.284728
CASC3 cancer susceptibility candidate 3 0.284371
FILIP1 filamin A interacting protein 1 0.284013
COL16A1 collagen, type XVI, alpha 1 0.283297
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 0.28151
UFL1 UFM1-specific ligase 1 0.28151
IL22 interleukin 22 0.280796
OPTC opticin 0.280439
CD5L CD5 molecule-like 0.279367
HMOX1 heme oxygenase 1 0.279011
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.277584
IL7 interleukin 7 0.276158
TARS threonyl-tRNA synthetase 0.274732
CCL21 chemokine (C-C motif) ligand 21 0.272597
IRF1 interferon regulatory factor 1 0.272241
LYZ lysozyme 0.270819
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.269043
WDR20 WD repeat domain 20 0.268687
F3 coagulation factor III (thromboplastin, tissue factor) 0.268332
CXCL9 chemokine (C-X-C motif) ligand 9 0.267977
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.266913
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.266913
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.266558
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.266558
AHSG alpha-2-HS-glycoprotein 0.265494
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.264431
LECT2 leukocyte cell-derived chemotaxin 2 0.263722
SULF1 sulfatase 1 0.263368
EBF4 early B-cell factor 4 0.263014
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.26266
IL36R interleukin 36 receptor 0.261599
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.261599
CCL13 chemokine (C-C motif) ligand 13 0.260538
GLRA3 glycine receptor, alpha 3 0.260184
PER2 period circadian clock 2 0.258417
SFRP4 secreted frizzled-related protein 4 0.256652
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 0.256652
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.255594
OPRM1 opioid receptor, mu 1 0.254536
FICD FIC domain containing 0.252422
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing 0.249608
ULK1 unc-51 like autophagy activating kinase 1 0.248203
CCL4 chemokine (C-C motif) ligand 4 0.24715
EPHB4 EPH receptor B4 0.24715
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.24715
MAB21L2 mab-21-like 2 (C. elegans) 0.246799
PLS1 plastin 1 0.246799
TADA1 transcriptional adaptor 1 0.246098
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.243995
LHX2 LIM homeobox 2 0.243295
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.242245
WNT1 wingless-type MMTV integration site family, member 1 0.242245
GREM2 gremlin 2, DAN family BMP antagonist 0.23945
DSG4 desmoglein 4 0.239101
PCOLCE2 procollagen C-endopeptidase enhancer 2 0.238403
TBL1X transducin (beta)-like 1X-linked 0.237357
MYD88 myeloid differentiation primary response 88 0.23666
ADAM17 ADAM metallopeptidase domain 17 0.23666
SPON1 spondin 1, extracellular matrix protein 0.236312
CPA6 carboxypeptidase A6 0.235964
ICAM2 intercellular adhesion molecule 2 0.235964
ACP5 acid phosphatase 5, tartrate resistant 0.235268
SDC2 syndecan 2 0.23492
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.233878
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.23353
F8 coagulation factor VIII, procoagulant component 0.232836
MTL5 metallothionein-like 5, testis-specific (tesmin) 0.232836
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.232836
CTSL cathepsin L 0.232142
TSPAN9 tetraspanin 9 0.231795
LEF1 lymphoid enhancer-binding factor 1 0.230755
DEFB4A defensin, beta 4A 0.230755
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.229716
MGARP mitochondria-localized glutamic acid-rich protein 0.228679
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.226952
EGR1 early growth response 1 0.226952
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.223509
DDN dendrin 0.223165
GREM1 gremlin 1, DAN family BMP antagonist 0.223165
MKX mohawk homeobox 0.222822
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.222822
EFNB2 ephrin-B2 0.222822
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.221793
DEFB103A defensin, beta 103A 0.221108
MIPOL1 mirror-image polydactyly 1 0.220766
USP33 ubiquitin specific peptidase 33 0.220766
OGN osteoglycin 0.219398
C7ORF49 chromosome 7 open reading frame 49 0.219398
TWF1 twinfilin actin binding protein 1 0.219057
SDC3 syndecan 3 0.218374
SMAD7 SMAD family member 7 0.218374
SEPT2 septin 2 0.218034
TNXB tenascin XB 0.217352
ANKLE2 ankyrin repeat and LEM domain containing 2 0.216672
E2F2 E2F transcription factor 2 0.216332
ARHGAP44 Rho GTPase activating protein 44 0.215314
NPY neuropeptide Y 0.214975
MXRA5 matrix-remodelling associated 5 0.214636
AMIGO2 adhesion molecule with Ig-like domain 2 0.214636
IRAK1 interleukin-1 receptor-associated kinase 1 0.214297
CRLF1 cytokine receptor-like factor 1 0.213621
HPX hemopexin 0.213283
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.211934
AP3D1 adaptor-related protein complex 3, delta 1 subunit 0.211597
TNXA tenascin XA (pseudogene) 0.210925
CD86 CD86 molecule 0.209248
SST somatostatin 0.208914
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.207912
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.206913
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.20658
PER1 period circadian clock 1 0.20658
ACP1 acid phosphatase 1, soluble 0.205916
DDIT3 DNA-damage-inducible transcript 3 0.205585
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 0.204593
LTA lymphotoxin alpha 0.203604
ATF2 activating transcription factor 2 0.203275
PZP pregnancy-zone protein 0.203275
DEFB103B defensin, beta 103B 0.201635
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.200982
XBP1 X-box binding protein 1 0.200982
ANXA2 annexin A2 0.200656
CRTAC1 cartilage acidic protein 1 0.200656
ADAM23 ADAM metallopeptidase domain 23 0.200331
PRKCH protein kinase C, eta 0.198709
SCARB1 scavenger receptor class B, member 1 0.198386
IFI44 interferon-induced protein 44 0.198386
SCARB2 scavenger receptor class B, member 2 0.196779
TBL1Y transducin (beta)-like 1, Y-linked 0.196779
CS citrate synthase 0.196139
OSCAR osteoclast associated, immunoglobulin-like receptor 0.196139
FST follistatin 0.196139
SAA4 serum amyloid A4, constitutive 0.194865
WNT5A wingless-type MMTV integration site family, member 5A 0.193915
PPARA peroxisome proliferator-activated receptor alpha 0.1936
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.193285
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.192971
MVD mevalonate (diphospho) decarboxylase 0.192657
POLR1A polymerase (RNA) I polypeptide A, 194kDa 0.192657
IL18BP interleukin 18 binding protein 0.192031
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 0.191719
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.189859
BCL9 B-cell CLL/lymphoma 9 0.188326
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.188326
NCOR2 nuclear receptor corepressor 2 0.188326
FAAH fatty acid amide hydrolase 0.187415
JAK2 Janus kinase 2 0.187113
DIO3 deiodinase, iodothyronine, type III 0.186811
KIF12 kinesin family member 12 0.18591
SYK spleen tyrosine kinase 0.18591
EHF ets homologous factor 0.185016
IL7R interleukin 7 receptor 0.185016
SQSTM1 sequestosome 1 0.185016
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.185016
ERV3-1 endogenous retrovirus group 3, member 1 0.185016
AQP3 aquaporin 3 (Gill blood group) 0.18472
CD36 CD36 molecule (thrombospondin receptor) 0.184128
NLRP3 NLR family, pyrin domain containing 3 0.183835
MYBPH myosin binding protein H 0.183248
GPNMB glycoprotein (transmembrane) nmb 0.182957
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.182957
PRDX5 peroxiredoxin 5 0.182957
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.181798
PDYN prodynorphin 0.18151
WNT5B wingless-type MMTV integration site family, member 5B 0.181222
TXN thioredoxin 0.181222
GDF7 growth differentiation factor 7 0.181222
NID2 nidogen 2 (osteonidogen) 0.181222
LGALS3 lectin, galactoside-binding, soluble, 3 0.180652
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.180652
CNN3 calponin 3, acidic 0.180367
OMD osteomodulin 0.179239
ICAM3 intercellular adhesion molecule 3 0.178126
KAT5 K(lysine) acetyltransferase 5 0.177851
TWIST1 twist family bHLH transcription factor 1 0.177301
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.176215
CHID1 chitinase domain containing 1 0.175679
NT5E 5'-nucleotidase, ecto (CD73) 0.175679
SRCAP Snf2-related CREBBP activator protein 0.175411
NGFR nerve growth factor receptor 0.174093
CXCL16 chemokine (C-X-C motif) ligand 16 0.173832
CCDC85B coiled-coil domain containing 85B 0.173832
ITGA6 integrin, alpha 6 0.173571
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.173571
ETV4 ets variant 4 0.173571
BECN1 beclin 1, autophagy related 0.173057
TYROBP TYRO protein tyrosine kinase binding protein 0.172799
FSTL1 follistatin-like 1 0.172799
CRHR2 corticotropin releasing hormone receptor 2 0.172291
BMP2K BMP2 inducible kinase 0.172038
AXIN2 axin 2 0.171535
CD53 CD53 molecule 0.171286
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.170789
CST3 cystatin C 0.170544
MATK megakaryocyte-associated tyrosine kinase 0.170054
CXCL13 chemokine (C-X-C motif) ligand 13 0.16933
CFDP1 craniofacial development protein 1 0.168617
MYDGF myeloid-derived growth factor 0.167452
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.167452
CD69 CD69 molecule 0.167224
S100A10 S100 calcium binding protein A10 0.166995
EEF1A1P6 eukaryotic translation elongation factor 1 alpha 1 pseudogene 6 0.166544
C6ORF25 chromosome 6 open reading frame 25 0.166095
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.166095
EFHD1 EF-hand domain family, member D1 0.165217
VASN vasorin 0.163938
FLT1 fms-related tyrosine kinase 1 0.163729
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.163729
MCAM melanoma cell adhesion molecule 0.163729
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.162306
CCL19 chemokine (C-C motif) ligand 19 0.161716
MARK2 MAP/microtubule affinity-regulating kinase 2 0.161331
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.160761
ITM2A integral membrane protein 2A 0.160387
HYLS1 hydrolethalus syndrome 1 0.160387
PRRC2A proline-rich coiled-coil 2A 0.160203
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.159838
DPP4 dipeptidyl-peptidase 4 0.15948
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.158778
PTH2R parathyroid hormone 2 receptor 0.158778
MGST1 microsomal glutathione S-transferase 1 0.158605
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.158266
CANT1 calcium activated nucleotidase 1 0.158266
ANXA1 annexin A1 0.158097
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.158097
AZU1 azurocidin 1 0.157929
DOK4 docking protein 4 0.157929